山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (3): 20-23.doi: 10.6040/j.issn.1673-3770.0.2015.024

• 论著 • 上一篇    下一篇

鼓室注射布地奈德混悬液治疗合并2型糖尿病的突发性耳聋42例

蒋路云, 谢慧, 谢艳, 李昕蓉   

  1. 成都中医药大学附属医院耳鼻咽喉头颈外科, 四川 成都 610072
  • 收稿日期:2015-01-09 修回日期:2015-04-07 发布日期:2015-06-16
  • 通讯作者: 李昕蓉。E-mail:amz.3@163.com E-mail:amz.3@163.com
  • 作者简介:蒋路云。E-mail:jly666@163.com

Intratympanic budesonide suspension injection to treat idiopathic sudden deafness with type Ⅱ diabetes mellitus in 42 patients

JIANG Luyun, XIE Hui, XIE Yan, LI Xinrong   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China
  • Received:2015-01-09 Revised:2015-04-07 Published:2015-06-16

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摘要： 目的 研究在治疗合并2型糖尿病的突发性耳聋患者时, 于静脉用药基础上增加鼓室注射布地奈德混悬液, 探讨此方式与口服强的松方式治疗这类患者后所获得恢复听力的差别。方法 将符合纳入标准且合并2型糖尿病的突发性耳聋患者84例(87耳), 分为A组(口服强的松组)及B组(布地奈德混悬液鼓室注射组)各42例, 在相同静脉用药及控制血糖的基础上, 分别行口服强的松或鼓室注射布地奈德混悬液。结果 将纯音听力改善程度分为痊愈、显效、有效、无效4个等级作为疗效判定标准, 进行单向有序分类资料的秩和检验, Mann-Whitney U检验的结果显示, Z=-3.274, P=0.001, 两组间的疗效差异有统计学意义(P<0.05), 布地奈德混悬液鼓室注射组疗效更好。同时对两组患者血糖测定的异常次数行χ2检验, chi-square检验的结果显示, χ2=214.482, P<0.001, 组间血糖控制情况差异也具有统计学意义(P<0.05), 鼓室用药造成患者血糖波动的情况较少。结论 在相同静脉用药及控制血糖的基础上, 鼓室注射布地奈德混悬液治疗合并2型糖尿病突发性耳聋患者, 疗效优于口服强的松, 且更有利于调整、控制患者的血糖水平。

关键词: 强的松, 布地奈德混悬液, 突发性耳聋, 2型糖尿病

Abstract: Objective To observe the clinical effectiveness of oral prednisone and intratympanic plus intravenous budesonide injection in the treatment of the patients of sudden deafness with type Ⅱ diabetes mellitus (DM). Methods The patients with sudden deafness plus type Ⅱ diabetes mellitus (84 cases, 87 ears) were randomly divided into group A (42 cases, 43 ears) and group B(42 cases, 44 ears). Both groups were given individualized medication to lower blood glucose, but same conventional treatment for sudden hearing loss. Oral prednisone was added in group A, while intratympanic injection of Budesonide suspensinon was applied to group B. Results The improvements of pure tone average were classified as 4 grades: cured, markedly effective, effective, and ineffective. The result of Mann-Whitney U test showed the two strategies of treatment had significant difference in the improvement of profound idiopathic sudden hearing loss (Z=-3.274, P=0.001), and the result of chi-square showed that there was also a significant difference in the numbers of abnormal plasma glucose between group A and group B (χ2=214.482, P<0.001). Conclusion With the individualized medications to lower blood glucose and conventional treatments, Intratympanic Budesonide suspension injection plus conventional regimen could be more effective for idiopathic sudden deafness in type Ⅱ DM patients than oral prednisone. And it is beneficial to maintain the stability of blood glucose level by the way of intratympanic injection of glucocorticoid.

Key words: Prednisone, Idiopathic sudden deafness, Type Ⅱ diabetes mellitus, Budesonide suspension

中图分类号: 

  • R764.43
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