山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 79-82.doi: 10.6040/j.issn.1673-3770.0.2015.170

• 综述 • 上一篇    下一篇

miRNA在头颈肿瘤的应用进展

周娟, 郑家法   

  1. 南华大学附属南华医院耳鼻咽喉科, 湖南 衡阳 421001
  • 收稿日期:2015-04-24 修回日期:2015-09-22 出版日期:2015-10-16 发布日期:2015-10-16
  • 通讯作者: 郑家法,E-mail:13975466338@139.com E-mail:13975466338@139.com
  • 作者简介:周娟,E-mail:1075765033@qq.com

Research progress of miRNA in head and neck cancers

ZHOU Juan, ZHENG Jiafa   

  1. Department of Otorhinolaryngology Head and Neck Surgery, Nanhua Hospital Affiliated to University of South China, Hengyang 421001, Hunan, China
  • Received:2015-04-24 Revised:2015-09-22 Online:2015-10-16 Published:2015-10-16

摘要: microRNA又称miRNA,是一类非编码的单链小分子RNA,通过与靶mRNA的3'UTR(3'末端非翻译区)不完全或完全互补配对调节基因的表达,在肿瘤的发生、发展中扮演着重要角色。本文就miRNA在头颈肿瘤的诊断、预后、治疗等方面作一综述。

关键词: miRNA, 头颈肿瘤, 基因

Abstract: A microRNA, abbreviated miRNA, is a non-coding single-stranded small molecular RNA. Through incomplete or complete complementary pairing with target mRNA 3' UTR (3' end untranslated region), it plays an important role in the occurrence and development of tumors. This paper reviews the role of miRNA in the diagnosis, prognosis and treatment of head and neck cancers.

Key words: Head and neck cancers, miRNA, Gene

中图分类号: 

  • R739.91
[1] Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer[J]. Oral Oncol, 2009, 45(4-5): 309-316.
[2] Nagadia R, Pandit P, Coman W B, et al. miRNAs in head and neck cancer revisited[J]. Cell Oncol (Dordr), 2013, 36(1): 1-7.
[3] Warnakulasuriya S. Causes of oral cancer—an appraisal of controversies[J]. Br Dent J, 2009, 207(10): 471-475.
[4] Lee R C, Feinbaum R L, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5): 843-854.
[5] Malumbres M. miRNAs and cancer: an epigenetics view[J]. Mol Aspects Med, 2012, 34: 863-874.
[6] Li J, Huang H, Sun L, et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor[J]. Clin Cancer Res, 2009, 15(12): 3998-4008.
[7] Yu Z W, Zhong L P, Ji T, et al. MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines[J]. Oral Oncol, 2010, 46(4): 317-322.
[8] Kozaki K, Imoto I, Mogi S, et al. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer[J]. Cancer Res, 2008, 68(7): 2094-2105.
[9] Avissar M, Christensen B C, Kelsey K T, et al. MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma[J]. Clin Cancer Res, 2009, 15(8): 2850-2855.
[10] 张春妮, 张辰宇. 体液microRNA作为新的无创伤性生物标志物的意义[J]. 分子诊断与治疗杂志, 2011, 3(3): 145-151. ZHANG Chunni, ZHANG Chenyu. The significance of humoral microRNA as a new biomarker for noninvasive biological[J]. J Mole Diagn Ther, 2011, 3(3): 145-151.
[11] 孙伟, 史冬泉, 蒋青. 血清microRNA的检测及临床应用进展[J]. 医学综述, 2011, 17(23): 3616-3618. SUN Wei, SHI Dongquan, JIANG Qing. Progress of detection and clinical application of serum microRNA[J]. Med Survey, 2011, 17(23): 3616-3618.
[12] Liu C J, Kao S Y, Tu H F, et al. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer[J]. Oral Dis, 2010, 16(4): 360-364.
[13] Park N J, Zhou H D, Elashoff D, et al. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection[J]. Clin Cancer Res, 2009, 15(17): 5473-5477.
[14] Siow M Y, Karen Ng L P, Vincent Chong V K, et al. Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma[J]. Oral Dis, 2014, 20(4): 345-351.
[15] Rather M I, Nagashri M N, Swamy S S, et al. Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: implications for cancer therapeutics[J]. J Biol Chem, 2013, 288(1): 608-618.
[16] Su J, Baigude H, McCarroll J, et al. Silencing microRNA by interfering nanoparticles in mice[J]. Nucleic Acids Res, 2011, 39(6): 38.
[17] 陈建, 王朝霞. 微小RNA: 肿瘤耐药治疗新靶点[J]. 现代肿瘤医学, 2012, 20(01): 191-196. CHEN Jian, WANG Zhaoxia. miRNA: Tumor drug resistance therapy target[J]. Mod Tumor Med, 2012, 20(1): 191-196.
[1] 宋西成. 加速康复外科理念在头颈肿瘤手术的应用价值[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 1-4.
[2] 魏东敏,李文明,钱晔,刘大昱,雷大鹏,潘新良. 颈侧清扫术[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 115-115.
[3] 李学新,姜震,岳建林,林云,孙睿杰,刘大昱,潘新良. 带蒂肌皮瓣及脏器瓣在咽、食管缺损修复中的应用[J]. 山东大学耳鼻喉眼学报, 2018, 32(1): 48-52.
[4] 林云,潘新良,刘大昱,孙睿杰,李学新,姜震,岳建林. 局部组织瓣在喉切除术后一期重建中的应用[J]. 山东大学耳鼻喉眼学报, 2018, 32(1): 56-60.
[5] 徐新博,马小洁,闫涛,含笑,张寒冰. 新型PAX3基因突变导致Waardenburg I型综合征[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 39-41.
[6] 赵栋栋, 王艺, 高建鲁. 原发性开角型青光眼易感基因研究进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 92-96.
[7] 孙菲菲,胡松群,唐艳,张洁,吴笛,邱金红,王志霞,张鲁平. 高通量基因捕获测序技术在12个耳聋家庭中的应用[J]. 山东大学耳鼻喉眼学报, 2017, 31(5): 45-49.
[8] 张明德,张祖平,于学民,魏燕红,袁英. RASSF2A基因甲基化在喉癌组织中的表达及意义[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 64-67.
[9] 许元腾,陈瑞庆,林功标,方秀玲,俞舒娟,梁晓华,张榕. RNAi沉默PDCD4基因对人喉癌Hep-2细胞增殖及β-catenin表达的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 110-114.
[10] 滕伟强,陈晓平,张燚,周恩晖,姚文昊,李力. 变应性鼻炎部分相关单体型模块基因单核苷酸多态性研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(4): 26-29.
[11] 赵军, 刘景, 王大江, 陈国玲, 王琪, 张晗. Foxp3基因转染的Teff细胞抗高危角膜移植排斥的作用[J]. 山东大学耳鼻喉眼学报, 2015, 29(1): 44-48.
[12] 贾传亮1,2,张丽净2,3综述,宋西成2审校. MGMT基因与头颈肿瘤的相关研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(3): 80-85.
[13] 罗小邹综述,洪育明审校. 候选转移抑制基因(MTSS1)与肿瘤关系的研究进展[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 79-83.
[14] 刘创明1,2,卢永田1,王晓彬1,苗北平1. 双岛胸大肌皮瓣在头颈肿瘤切除、重建术中的应用[J]. 山东大学耳鼻喉眼学报, 2013, 27(3): 13-15.
[15] 柴吉鑫,贺青卿,庄大勇,郑鲁明,周鹏. 甲状腺乳头状微小癌癌基因和肿瘤标志物研究进展[J]. 山东大学耳鼻喉眼学报, 2012, 26(4): 82-86.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!