山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (6): 71-73.doi: 10.6040/j.issn.1673-3770.0.2015.312

• 论著 • 上一篇    下一篇

2型糖尿病患者糖化血红蛋白水平对干眼症的影响

王露萍, 吴欣怡   

  1. 山东大学齐鲁医院眼科, 山东 济南 250012
  • 收稿日期:2015-07-28 出版日期:2015-12-16 发布日期:2015-12-16
  • 通讯作者: 吴欣怡. E-mail:xywu8868@163.com E-mail:xywu8868@163.com
  • 作者简介:王露萍. E-mail:jinanwlp@163.com

Effect of glycosylated hemoglobin on dry eye in patients with type 2 diabetes mellitus

WANG Luping, WU Xinyi   

  1. Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-07-28 Online:2015-12-16 Published:2015-12-16

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摘要： 目的 探讨2型糖尿病患者糖化血红蛋白水平对干眼的影响.方法 收集140例2型糖尿病患者,根据糖化血红蛋白(HbA1c)水平,将其分为血糖控制稳定组(70例)和血糖控制不佳组(70例),分别问询干眼症状并测定泪液分泌试验(SIt)、泪膜破裂时间(BUT)及角膜荧光素染色(FL),对两组干眼症状和各项检查结果进行统计学分析.结果 血糖控制不佳组老年患者及男性患者干眼症状的发生率明显高于血糖控制稳定组.两组泪膜功能检查:血糖控制不佳组老年男性及女性患者与血糖控制稳定组相比,泪液分泌试验(SIt)、泪膜破裂时间(BUT)降低,差异均有统计学意义(P<0.05);两组中青年患者的SIt、BUT差异无统计学意义(P>0.05).各亚组的角膜荧光素染色(FL)检查结果无明显差别(P>0.05).HbA1c水平与老年糖尿病患者的干眼症状发生率呈正相关,与SIt、BUT结果呈负相关.结论 2型糖尿病老年患者的HbA1c水平与干眼相关,控制其HbA1c水平有助于改善干眼症状.

关键词: 2型糖尿病, 干眼, 糖化血红蛋白

Abstract: Objective To evaluate the effect of glycosylated hemoglobin on dry eye in patients with type 2 diabetes mellitus. Methods A total of 140 patients with type 2 diabetes mellitus were collected and divided into two groups: poor in glucose control group (n=70) and good in glucose control group (n=70), according to the level of glycosylated hemoglobin A1c (HbA1c). All patients were inquired about dry eye svndrome and received the examinations as follows: Schirmer I test (SIt), tear break-up time (BUT) and corneal fluorescein staining (FL). Results The elderly and male patients of poor in glucose control group showed higher incidence of dry eye syndrome than that of good in glucose control group, showing a significant difference between two groups (P<0.05). The elderly patients of poor in glucose control group showed lesser SIt and faster BUT than controls (P<0.05); there were no differences among SIt, BUT in young and middle patients of two groups. HbA1c level was positively correlated with dry eye svndrome, and negatively correlated with SIt, BUT. Conclusion The HbA1c level was correlated with dry eye in elderly patients with type 2 diabetes mellitus. It has great clinical value by controlling the glycosylated hemoglobin levels on patients with type 2 diabetes mellitus.

Key words: Dry eye, Glycosylated hemoglobin A1c, Type 2 diabetes mellitus

中图分类号: 

  • R587.2
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