热脉动系统对轻、中度睑板腺功能障碍治疗的临床观察

doi:10.6040/j.issn.1673-3770.0.2017.495

山东大学耳鼻喉眼学报 ›› 2018, Vol. 32 ›› Issue (3): 91-95.doi: 10.6040/j.issn.1673-3770.0.2017.495

热脉动系统对轻、中度睑板腺功能障碍治疗的临床观察

李上¹,张薇¹,卢红双²,臧云晓²,董宏伟¹,郭纯刚¹,潘志强²,接英²

1.首都医科大学附属北京佑安医院眼科, 北京 100069;
2.北京同仁眼科中心首都医科大学附属北京同仁医院, 北京 100730

收稿日期:2017-11-26 出版日期:2018-05-20 发布日期:2018-05-20
通讯作者: 接英. E-mail:jie_yingcn@aliyun.com
基金资助:
国家自然科学基金(81170824);北京市自然科学基金(7182037);卫生系统高层次卫生技术人才培养计划(2013-3-055)

Clinical observations following thermal pulsation system treatment for mild and moderate meibomian gland dysfunction

LI Shang¹, ZHANG Wei¹, LU Hongshuang², ZANG Yunxiao², DONG Hongwei¹, GUO Chungang¹, PAN Zhiqiang², JIE Ying²

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2017-11-26 Online:2018-05-20 Published:2018-05-20

摘要/Abstract

摘要： 目的评价热脉动系统LipiFlow对轻、中度睑板腺功能障碍(MGD)的患者治疗并随访6个月的临床效果。方法回顾性分析2016年3月至2016年11月在北京佑安医院眼科就诊,并进行LipiFlow治疗的15例(30眼)睑板腺功能障碍患者的临床资料。受试者分别在治疗前,治疗后3个月,治疗后6个月进行SPEED问卷,不完全眨眼比率(PB),脂质层厚度(LLT),泪膜破裂时间(TBUT),基础泪液分泌量(SIt)和睑板腺开口油脂分泌情况(MGYLS)。结果 SPEED问卷评分在治疗后3个月和6个月时分别为10.20±3.57和9.87±3.68,与治疗前的12.13±2.42相比降低。PB比率在治疗后3个月和6个月时分别为60%和62.45%,与治疗前的72.24%相比下降。LLT在治疗前、治疗后3个月和治疗后6个月分别为(71.70±21.23)nm,(72.03±20.52)nm和(74.60±20.07)nm。TBUT在治疗前、治疗后3个月和治疗后6个月分别为(5.37±2.19)s,(6.33±2.34)s和(6.40±2.50)s。 SIt在治疗前、治疗后3个月和治疗后6个月分别为(5.30±4.41)mm,(5.93±4.51)mm和(7.43±7.26)mm。MGYLS在治疗前、治疗后3个月和治疗后6个月分别为3.50±2.11,4.23±1.99和3.83±1.97。LLT,TBUT,SIt和MGYLS三个时间点进行两两比较,无统计学差异。结论热脉动系统可以减轻轻、中度睑板腺功能障碍的主观症状,同时改善不完全眨眼的比率,可以巩固治疗效果长达6个月。

关键词: 热脉动系统, LipiFlow, 睑板腺功能障碍

Abstract: Objective To assess the clinical outcomes of using Lipiflow thermal pulsation system, on mild to moderate meibomian gland dysfunction(MGD), during treatment and at the 3 and 6 months follow up visit. Methods A retrospective analysis of clinical data of MGD patients who sought medical help and underwent LipiFlow treatment at Beijing Youan Hospital from March to November 2016, was conducted. The participants answered a SPEED questionnaire for before, and 3 and 6 months after treatment. In addition, other indicators assessed included, partial blinks(PB), lipid layer thickness(LLT), tear break-up time(TBUT), Schirmer I test(SIT), and meibomian glands yielding liquid secretion(MGYLS). Results SPEED scores at 3 and 6 months, after treatment, were(10.20±3.57)and(9.87±3.68)respectively, significantly lower than(12.13±2.42)before treatment. PB rate assessed at the same time points after treatment was 60% and 62.4%, significantly different than 72.24% before treatment. The other scores, in the order before treatment, 3 and 6 months after treatment, were as follows: LLT scores were(71.70±21.23),(72.03±20.52), and(74.60±20.07)nm; TBUT scores were(5.37±2.19),(6.33±2.34), and(6.40±2.50)s; SIT scores were(5.30±4.41),(5.93±4.51), and(7.43±7.26)mm; and MGYLS scores were(3.50±2.11),(4.23±1.99), and(3.83±1.97). No statistically significant differences were found for LLT, TBUT, SIT, and MGYLS scores. Conclusion Subjective symptoms were improved by thermal pulsation system treatment in mild and moderate MGDs, and PB rates were lowered. The efficacy lasted for up to 6 months.

Key words: Meibomian gland dysfunction, LipiFlow, Thermal pulsation system

中图分类号:

R777

李上,张薇,卢红双,臧云晓,董宏伟,郭纯刚,潘志强,接英. 热脉动系统对轻、中度睑板腺功能障碍治疗的临床观察[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 91-95.

LI Shang, ZHANG Wei, LU Hongshuang, ZANG Yunxiao, DONG Hongwei, GUO Chungang, PAN Zhiqiang, JIE Ying. Clinical observations following thermal pulsation system treatment for mild and moderate meibomian gland dysfunction[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 91-95.

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热脉动系统对轻、中度睑板腺功能障碍治疗的临床观察

Clinical observations following thermal pulsation system treatment for mild and moderate meibomian gland dysfunction

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