山东大学耳鼻喉眼学报 ›› 2020, Vol. 34 ›› Issue (6): 58-62.doi: 10.6040/j.issn.1673-3770.0.2019.546

• • 上一篇    

喉癌患者术前中性粒细胞/淋巴细胞比值与淋巴结转移的相关性研究

庞振文1,黄愉峰1,杨爱芳2,曾先捷1   

  1. 1. 广西医科大学附属肿瘤医院 头颈外科, 广西 南宁 530021;
    2. 广西医科大学附属肿瘤医院 实验研究部, 广西 南宁 530021
  • 发布日期:2021-01-11
  • 通讯作者: 曾先捷. E-mail:zengxianjie@gxmu.edu.cn
  • 基金资助:
    广西自然科学基金项目(2014GXNSFBA402002,2015GXNSFAA139203)

Correlation between Preoperative neutrophil/lymphocyte ratio and lymph node metastasis in patients with laryngeal cancer

PANG Zhenwen1, HUANG Yufeng1, YANG Aifang2, ZENG Xianjie1   

  1. 1. Department of Head and Neck Surgery, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, China;
    2. Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, China
  • Published:2021-01-11

摘要: 目的 研究探讨喉癌患者术前中性粒细胞/淋巴细胞比值(NLR)与淋巴结转移的关系。 方法 选取2008年1月至2017年12月广西医科大学附属肿瘤医院收治的102例喉癌患者,以术前NLR为因变量对喉癌临床病理分期及淋巴结检测结果进行分析。 结果 术前NLR>2.2患者的转移度和转移率高于NLR≤2.2的患者(P<0.001);术前NLR>2.2组的患者中,淋巴结分期(N+)>N0者多于术前NLR≤2.2组(P<0.001)。肿瘤早期(T1,T2)患者的NLR均值较局晚期(T3,T4)的低,后者的淋巴结转移率和转移度较高(P<0.001);临床Ⅳ期患者NLR的均值、淋巴结转移率和转移度明显较Ⅲ期的高(P<0.05)。声门上型、声门型的患者中,术前NLR>2.2组的淋巴结转移率及转移度高于NLR≤2.2组(P<0.05);声门下型的患者中,淋巴结转移率差异比较无统计学意义(P>0.05),而淋巴结转移度差异比较有统计学意义(P<0.05)。 结论 喉癌患者术前NLR的高低与淋巴结转移之间有相关性,能在一定程度上反映淋巴结转移的程度,可为临床治疗提供有价值的参考依据。

关键词: 喉癌, 临床病理, 术前中性粒细胞/淋巴细胞比值, 淋巴结转移

Abstract: Objective To investigate the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR)and lymph node metastasis in patients with laryngeal cancer. Methods A total of 102 patients with laryngeal cancer admitted to the Affiliated Cancer Hospital of Guangxi Medical University from January 2008 to December 2017 were enrolled. The preoperative NLR was used as the dependent variable to analyze the clinical pathological staging and lymph node test results of laryngeal cancer. Results The patients with preoperative NLR>2.2 has higher transfer rate and metastasis than the patients with preoperative NLR≤2.2 and the difference was significant(P<0.001).The lymph node stage of patients with preoperative NLR>2.2 was significantly higher than that of the patients with preoperative NLR≤2.2, and the difference was significant(P<0.001).The mean NLR of patients with early tumor(T1,T2)was lower than that of patients with late tumor(T3,T4), the latter had higher lymph node transfer rate and metastasis, and the difference was statistically significant(P<0.001).The mean value of NLR in clinical stage IV patients with transfer rate and metastasis were significantly higher than that of stage III, and the difference was also statistically significant(P<0.05). Among patients with supraglottic and glottic carcinoma, the preoperative NLR>2.2 group had higher lymph node metastasis rate and metastasis than NLR≤2.2 group, and the difference was statistically significant(P<0.05); There was no significant difference in lymph node metastasis for subglottic patients(P>0.05), whereas the difference in lymph node metastasis was statistically significant(P<0.05). Conclusion There is a correlation between the preoperative NLR level and lymph node metastasis in patients with laryngeal cancer, which can reflect the degree of lymph node metastasis to some extent, and provide a valuable reference for clinical treatment.

Key words: laryngeal carcinoma, clinical pathology, preoperative NLR, lymph node metastasis.

中图分类号: 

  • R765.4
[1] Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015[J]. CA: A Cancer J Clin, 2016, 66(2): 115-132. doi:10.3322/caac.21338.
[2] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016[J]. CA: A Cancer J Clin, 2016, 66(1): 7-30. doi:10.3322/caac.21332.
[3] 沈楚霞,李彦仕,王志海,等. cN0喉癌颈部淋巴结转移的特征分析[J]. 中华耳鼻咽喉科头颈外科杂志,2019,54(5):343-348. doi: 10.3760/cma.j.issn.1673-0860.2019.05.006. SHEN Chuxia, LI Yanshi, WANG Zhihai, et al. Characteristics of cervical lymph node metastasis of cN0 laryngeal carcinoma[J]. Chinese Journal of Otolaryngology Head and Neck Surgery, 2019, 54(5): 343-348. doi: 10.3760/cma.j.issn.1673-0860.2019.05.006.
[4] Yang JC, Hsueh CY, Cao WJ, et al. Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for hypopharyngeal squamous cell carcinoma[J]. Acta Otolaryngol, 2018, 138(8): 734-740. doi:10.1080/00016489.2018.1449965.
[5] 吴静, 刘业海. 头颈部鳞状细胞癌的靶向治疗研究进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 97-102. doi:10.6040/j.issn.1673-3770.0.2018.058. WU Jing, LIU Yehai. Targeted therapy for head and neck squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 97-102. doi:10.6040/j.issn.1673-3770.0.2018.058.
[6] Eskiizmir G, Uz U, Onur E, et al. The evaluation of pretreatment neutrophil-lymphocyte ratio and derived neutrophil-lymphocyte ratio in patients with laryngeal neoplasms[J]. Braz J Otorhinolaryngol, 2019, 85(5): 578-587. doi:10.1016/j.bjorl.2018.04.013.
[7] Du JT, Liu JF, Zhang XY, et al. Pre-treatment neutrophil-to-lymphocyte ratio predicts survival in patients with laryngeal cancer[J]. Oncol Lett, 2018, 15(2): 1664-1672. doi:10.3892/ol.2017.7501.
[8] 胡艳红, 孙海燕, 赵国锋, 等. 术前血小板淋巴细胞比值对喉癌患者预后评估的临床意义[J]. 中国耳鼻咽喉头颈外科, 2019, 26(1): 48-50. doi:10.16066/j.1672-7002.2019.01.013.
[9] 蒋奕, 王惠临, 刘剑仑. 中性粒细胞/淋巴细胞比值评估肿瘤预后价值的研究进展[J]. 中国癌症防治杂志, 2016, 8(5): 329-332.
[10] Chen LY, Zeng H, Yang JP, et al. Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma[J]. BMC Cancer, 2018, 18(1): 816. doi:10.1186/s12885-018-4730-x.
[11] Cho Y, Kim JW, Yoon HI, et al. The prognostic significance of neutrophil-to-lymphocyte ratio in head and neck cancer patients treated with radiotherapy[J]. J Clin Med, 2018, 7(12): E512. doi:10.3390/jcm7120512.
[12] 王心怡, 马磊, 江鹏, 等. 中性粒细胞/淋巴细胞比值对舌鳞状细胞癌患者预后的预测价值[J]. 中华肿瘤防治杂志, 2017, 24(6): 409-413. doi:10.16073/j.cnki.cjcpt.2017.06.011. WANG Xinyi, MA Lei, JIANG Peng, et al. Prognostic value of neutrophil-to-lymphocyte ratio in the tongue squamous cell carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2017, 24(6): 409-413. doi:10.16073/j.cnki.cjcpt.2017.06.011.
[13] Tachibana T, Orita Y, Marunaka H, et al. Neck metastasis in patients with T1-2 supraglottic cancer[J]. Auris Nasus Larynx, 2018, 45(3): 540-545. doi:10.1016/j.anl.2017.06.002.
[14] Galdiero MR, Bonavita E, Barajon I, et al. Tumor associated macrophages and neutrophils in cancer[J]. Immunobiology, 2013, 218(11): 1402-1410. doi:10.1016/j.imbio.2013.06.003.
[15] Hurt B, Schulick R, Edil B, et al. Cancer-promoting mechanisms of tumor-associated neutrophils[J]. Am J Surg, 2017, 214(5): 938-944. doi:10.1016/j.amjsurg.2017.08.003.
[16] Hsueh C, Tao L, Zhang M, et al. The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer[J]. Oncotarget, 2017, 8(36): 60514-60527. doi:10.18632/oncotarget.16234.
[17] 李晓明. 喉癌治疗中喉功能保留的历史、现状和未来[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 1-5. LI Xiaoming. History, current status and future of laryngeal function retention in laryngeal cancer treatment[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 1-5. doi:10.6040/j.issn.1673-3770.1.2019.030.
[18] Patel KB, Nichols AC, Fung K, et al. Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy[J]. Le J D'oto - Rhino - Laryngol Et De Chir Cervico - Faciale, 2018, 47(1): 19. doi:10.1186/s40463-018-0262-2.
[19] Smee R, Williams JR, Kotevski DP. Management of locally advanced T3-4 glottic laryngeal carcinomas[J]. J Laryngol Otol, 2018, 132(7): 642-650. doi:10.1017/S0022215118000993.
[20] del Bon F, Piazza C, Lancini D, et al. Open partial horizontal laryngectomies for T3-T4 laryngeal cancer: prognostic impact of anterior vs. posterior laryngeal compartmentalization[J]. Cancers(Basel), 2019, 11(3): E289. doi:10.3390/cancers11030289.
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