山东大学耳鼻喉眼学报 ›› 2020, Vol. 34 ›› Issue (6): 123-128.doi: 10.6040/j.issn.1673-3770.0.2020.031

• • 上一篇    

高迁移率族蛋白B1与变应性鼻炎的相关性

朱正茹综述张小兵审校   

  1. 兰州大学第一医院 耳鼻喉头颈外科, 甘肃 兰州 730000
  • 发布日期:2021-01-11
  • 通讯作者: 张小兵. E-mail:790736924@qq.com

Correlation between high-mobility group box-1 and allergic rhinitis

ZHU ZhengruOveriew,ZHANG XiaobingGuidance   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • Published:2021-01-11

摘要: 变应性鼻炎(AR)是IgE介导的鼻黏膜的非感染性炎性疾病,其特征是炎症介质的上调和鼻黏膜的炎症细胞浸润。HMGB1作为典型的警报蛋白和损伤相关模式分子,在介导炎症反应、细胞迁移、组织侵袭等中起着多种作用。目前关于HMGB1与变应性疾病的研究主要集中在系统性红斑狼疮、哮喘、特应性皮炎中,对于其在AR中的作用尚有争议,论文就近年来有关学者对HMGB1在AR发病机制中的相关研究进行总结。

关键词: 高迁移率族蛋白B1, 变应性鼻炎, 发病机制, 炎症, 受体, 信号通路

Abstract: Allergic rhinitis(AR)is a noninfectious inflammatory disease of the nasal mucosa mediated by IgE and characterized by the upregulation of inflammatory mediators and infiltration of inflammatory cells in the nasal mucosa. As a typical warning protein and damage-related model molecule, high-mobility group box-1(HMGB1)plays a variety of roles in mediating inflammatory response, cell migration, and tissue invasion. Currently, studies on HMGB1 and allergic diseases mainly focus on systemic lupus erythematosus, asthma, and atopic dermatitis, whereas the role of HMGB1 in AR is still controversial. This article summarizes the relevant researches on the role of HMGB1 in the pathogenesis of AR.

Key words: High mobility group box-1, Allergic rhinitis, Pathogenesis, Inflammation, Receptor, Signal pathway

中图分类号: 

  • R765.21
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