山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (3): 125-130.doi: 10.6040/j.issn.1673-3770.0.2020.191

• 临床研究 • 上一篇    

谷氧还蛋白在眼病中的作用研究进展

付奕豪1,2,徐逸轩1,2综述严宏1,3,张婕1审校   

  1. 1. 空军军医大学唐都医院 眼科, 陕西 西安 710038;
    2. 空军军医大学基础医学院, 陕西 西安 710032;
    3. 陕西省眼科医院/西北工业大学附属西安市第四医院, 陕西 西安 710004
  • 发布日期:2021-05-14
  • 通讯作者: 张婕. E-mail:jessicazhangjie@hotmail.com
  • 基金资助:
    国家自然科学基金青年科学项目(81300743)

Recent research advances in the role of glutaredoxin in oculopathy

FU Yihao1,2, XU Yixuan1,2Overview,YAN Hong1,3, ZHANG Jie1Guidance   

  1. 1. Department of Ophthalmonogy, Tangdu Hospital, Air Force Medical University, Xi'an 710038, Shaanxi, China;
    2. Basic Medical School, Air Force Medical University, Xi'an 710032, Shaanxi, China;
    3. Shaanxi Eye Hospital of Xi'an Fourth Hospital, Northwestern Polytechnical University, Xi'an 710004, Shaanxi, China
  • Published:2021-05-14

摘要: 谷氧还蛋白(Grx)是巯基-二硫化物氧化还原酶家族的重要一员,其主要功能是还原蛋白质和谷胱甘肽形成的二硫化物,从而维持细胞的氧化还原平衡。Grx存在于全身许多组织中。近年来,Grx在眼部疾病中发挥的保护功能和与其他抗氧化酶的协同作用不断被阐明,对于Grx有了更加深入的认识。综述主要总结了Grx在治疗眼病研究中所取得的最新进展。

关键词: 谷氧还蛋白, 氧化应激, 抗氧化酶, 白内障, 眼病, 基因敲除小鼠

Abstract: Glutaredoxin(Grx)is animportant member of the thiol disulfide oxidoreductase protein family. The primary function is to dethiolate glutathionylated proteins, thus maintaining cellular redox homeostasis. Grx is expressed in many tissues throughout the body. In recent years, the protective function of Grx in oculopathy and its synergistic effect with other antioxidative enzymes have been increasingly elucidated, leading to a better understanding of this protein. This review summarizes the latest research on the role of Grx in oculopathy.

Key words: Glutaredoxin, Oxidative stress, Antioxidase, Cataract, Oculopathy, Gene knockout mice

中图分类号: 

  • R77
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