山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (4): 96-100.doi: 10.6040/j.issn.1673-3770.0.2020.330

• 综述 • 上一篇    下一篇

喉乳头状瘤手术治疗的研究进展

牛子捷,肖洋,王军,马丽晶   

  1. 首都医科大学), 北京 100730
  • 发布日期:2021-08-05
  • 通讯作者: 王军. E-mail:wmzi2002@163.com
  • 基金资助:
    北京市自然科学基金资助(7182036);北京市医院管理中心儿科学科协同发展中心专项经费资助(XTCX201823);北京市中医药科技发展资金项目(JJ-2020-17)

Progress in the surgical treatment of recurrent laryngeal papillomatosis

NIU Zijie, XIAO Yang,WANG Jun,MA Lijinng   

  1. Department of Otolaryngology-Head and Neck Surgery, Bejing Tongren Hospital, Capital Medical University / Key Laboratory of Otolaryngology-Head and Neck Surgery, Capital Medical University, Ministry of Education, Beijing 100730, China
  • Published:2021-08-05

摘要: 治疗喉乳头状瘤是耳鼻咽喉科医生面临的巨大挑战,选择合适的治疗方式可以减少复发率、并发症从而改善患者生活质量。喉乳头状瘤是儿童喉部最常见的良性肿瘤,是引起儿童声音嘶哑的常见原因,因易复发需要多次手术治疗,给患儿及其家庭造成沉重的心理压力和经济负担。综述目前临床常用的手术治疗方式和进展,为临床医生在此病治疗的手术方式方面选择提供思路。

关键词: 喉乳头状瘤, 声音嘶哑, 人乳头状瘤病毒, CO2激光, 喉显微吸切器, 达芬奇手术机器人, 低温等离子射频消融系统

Abstract: The treatment of laryngeal papilloma is challenging for otolaryngologists. Administering the appropriate treatment can reduce the recurrence rate and the incidence of complications and improve the quality of life of patients. Laryngeal papilloma is the most common benign tumor of the larynx and the common cause of hoarseness in children. Because of recurrence, laryngeal papilloma requires multiple surgeries, and this places psychological and economic burdens on children and their families. In this paper, the common surgical methods and treatment approaches are reviewed to guide the selection of surgical methods by clinicians.

Key words: Laryngeal papillomatosis, Hoarseness, Human papillomavirus, CO2 laser, Microdebrider, Leonardo Da Vinci surgical robot, Low-temperature plasma radio-frequency ablation system

中图分类号: 

  • R739.65
[1] Seedat RY, Schall R. Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis: a South African perspective[J]. Clin Otolaryngol, 2018, 43(2): 533-537. doi:10.1111/coa.13016.
[2] San Giorgi MRM, van den Heuvel ER, Tjon Pian Gi REA, et al. Age of onset of recurrent respiratory papillomatosis: a distribution analysis[J]. Clin Otolaryngol, 2016, 41(5): 448-453. doi:10.1111/coa.12565.
[3] Lawlor C, Balakrishnan K, Bottero S, et al. International Pediatric Otolaryngology Group(IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations[J]. Int J Pediatr Otorhinolaryngol, 2020, 128: 109697. doi:10.1016/j.ijporl.2019.109697.
[4] Seedat RY. Juvenile-onset recurrent respiratory papillomatosis diagnosis and management-A developing country review[J]. Pediatric Health Med Ther, 2020, 11: 39-46. doi:10.2147/phmt.s200186.
[5] 孙睿杰, 许风雷, 刘大昱, 等. 显微支撑喉镜下CO2激光手术或联合干扰素治疗复发性小儿喉乳头状瘤疗效对比[J]. 山东大学耳鼻喉眼学报, 2012, 26(6): 23-25. doi:10.6040/j.issn.1673-3770.2012.06.008. SUN Ruijie, XU Fenglei, LIU Dayu, et al. Effect of CO2 laser surgery combined with interferon on recurrent juvenile laryngeal papillomatosis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2012, 26(6): 23-25. doi:10.6040/j.issn.1673-3770.2012.06.008.
[6] Novakovic D, Cheng ATL, Zurynski Y, et al. A prospective study of the incidence of juvenile-onset recurrent respiratory papillomatosis after implementation of a national HPV vaccination program[J]. J Infect Dis, 2018, 217(2): 208-212. doi:10.1093/infdis/jix498.
[7] Yan Y, Olszewski AE, Hoffman MR, et al. Use of lasers in laryngeal surgery[J]. J Voice, 2010, 24(1): 102-109. doi:10.1016/j.jvoice.2008.09.006.
[8] Papaioannou VA, Lux A, Voigt-Zimmermann S, et al. Treatment outcomes of recurrent respiratory papillomatosis: Retrospective analysis of juvenile and adult cases[J]. HNO, 2018, 66(suppl 1): 7-15. doi:10.1007/s00106-017-0378-0.
[9] Xu W, Han D, Hou L, et al. Voice function following CO2 laser microsurgery for precancerous and early-stage glottic carcinoma[J]. Acta Otolaryngol, 2007, 127(6): 637-641. doi:10.1080/00016480600987776.
[10] Ivancic R, Iqbal H, DeSilva B, et al. Current and future management of recurrent respiratory papillomatosis[J]. Laryngoscope Investig Otolaryngol, 2018, 3(1): 22-34. doi:10.1002/lio2.132.
[11] Preciado DA. Hemostasis in airway surgery[J]. Otolaryngol Clin N Am, 2016, 49(3): 691-703. doi:10.1016/j.otc.2016.02.007.
[12] Rasmussen ER, Schnack DT, Jørkov AS, et al. Long-term follow-up and outcome in patients with recurrent respiratory laryngeal papillomatosis [J]. Danish Medical Journal, 2017, 64(12): A5424.
[13] Scatolini ML, Labedz G, Cocciaglia A, et al. Laryngeal sequelae secondary to surgical treatment for recurrent respiratory papillomatosis in children[J]. Int J Pediatr Otorhinolaryngol, 2020, 130: 109815. doi:10.1016/j.ijporl.2019.109815.
[14] Holler T, Allegro J, Chadha NK, et al. Voice outcomes following repeated surgical resection of laryngeal papillomata in children[J]. Otolaryngol Head Neck Surg, 2009, 141(4): 522-526. doi:10.1016/j.otohns.2009.06.080.
[15] 杨庆文, 徐文, 郭伟, 等. CO2激光结合显微电动吸切器治疗重症幼年型复发性呼吸道乳头状瘤回顾性分析[J]. 中华耳鼻咽喉头颈外科杂志, 2017, 52(10): 733-737. doi:10.3760/cma.j.issn.1673-0860.2017.10.004. YANG Qingwen, XU Wen, GUO Wei, et al. A retrospective analysis of CO2 laser and microdebrider for the treatment of severe juvenile on-set recurrent respiratory papillomatosis[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2017, 52(10): 733-737. doi:10.3760/cma.j.issn.1673-0860.2017.10.004.
[16] Hendriksma M, van Loon Y, C Klop WM, et al. Quality of life and voice outcome of patients treated with transoral CO(2)laser microsurgery for early glottic carcinoma(T1-T2): a 2-year follow-up study [J]. Eur Arch Otorhinolaryngol,2019,276(3):805-814. doi: 10.1007/s00405-019-05348-1.
[17] Ford DA. Safety considerations for laser surgery of the airway[J]. AORN J, 2018, 107(3): P15-P16. doi:10.1002/aorn.12108.
[18] Strong MS, Vaughan CW, Healy GB, et al. Recurrent respiratory papillomatosis[J]. Ann Otol Rhinol Laryngol, 1976, 85(4): 508-516. doi:10.1177/000348947608500412.
[19] Papaspyrou G, Schick B, Papaspyrou S, et al. Retrospective analysis of laser vs other therapeutic modalities for laryngeal papillomatosis: European multicenter study[J]. j buon, 2016, 21(5): 1274-1278.
[20] 雷文斌, 刘其洪. CO2激光手术治疗复发性呼吸道乳头状瘤[J]. 山东大学耳鼻喉眼学报, 2018, 32(6): 8-12. doi:10.6040/j.issn.1673-3770.1.2018.014. LEI Wenbin, LIU Qihong. Progress in the treatment of recurrent respiratory papillomatosis using a CO2 laser[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 8-12. doi:10.6040/j.issn.1673-3770.1.2018.014.
[21] Bowles PF, Liu A, Harries ML. CO2 laser “Ablation Suction” technique for treatment of laryngeal recurrent respiratory papillomatosis[J]. Clin Otolaryngol,2019,44(5):884-885.doi: 10.1111/coa.13278.
[22] Ilmarinen T, Auvinen E, Hiltunen-Back E, et al. Transmission of human papillomavirus DNA from patient to surgical masks, gloves and oral mucosa of medical personnel during treatment of laryngeal papillomas and genital warts [J]. Eur Arch Otorhinolaryngol,2012,269(11):2367-2371.doi: 10.1007/s00405-012-2049-9.
[23] Zeitels SM, Akst LM, Burns JA, et al. Office-based 532-nm pulsed KTP laser treatment of glottal papillomatosis and dysplasia[J]. Ann Otol Rhinol Laryngol, 2006, 115(9): 679-685. doi:10.1177/000348940611500905.
[24] Kuet ML, Pitman MJ. Photoangiolytic laser treatment of recurrent respiratory papillomatosis: a scaled assessment[J]. J Voice, 2013, 27(1): 124-128. doi:10.1016/j.jvoice.2012.07.003.
[25] Lechien JR, Burns JA, Akst LM. The use of 532-nanometer-pulsed potassium-titanyl-phosphate(KTP)laser in laryngology: a systematic review of current indications, safety, and voice outcomes[J]. Ear Nose Throat J, 2020: 145561319899183. doi:10.1177/0145561319899183.
[26] Pynnonen M, Brinkmeier JV, Thorne MC, et al. Coblation versus other surgical techniques for tonsillectomy[J]. Cochrane Database Syst Rev, 22(8):CD004619. doi: 10.1002/14651858.CD004619.pub3.
[27] Hao F, Yue LY, Yin XY, et al. Low-temperature radiofrequency coblation reduces treatment interval and post-operative pain of laryngotracheal recurrent respiratory papillomatosis[J]. Biosci Rep, 2020, 40(5): BSR20192005. doi:10.1042/bsr20192005.
[28] 魏锐文, 范敏, 崔榕, 等. CO2激光与等离子两种方法治疗喉乳头状瘤的疗效对比[J]. 四川医学, 2017, 38(7): 787-790. doi:10.16252/j.cnki.issn1004-0501-2017.07.021. WEI Ruiwen, FAN Min, CUI Rong, et al. Comparative study on therapeutic effectiveness of CO2 laser and low-temperature plasma on laryngeal Papilloma[J]. Sichuan Medical Journal, 2017, 38(7): 787-790. doi:10.16252/j.cnki.issn1004-0501-2017.07.021.
[29] Miller AJ, Gardner GM. In-office vs. operating room procedures for recurrent respiratory papillomatosis[J]. Ear Nose Throat J, 2017, 96(4/5): E24-E28. doi:10.1177/0145561319889538.
[30] del Signore AG, Shah RN, Gupta N, et al. Complications and failures of office-based endoscopic angiolytic laser surgery treatment[J]. J Voice, 2016, 30(6): 744-750. doi:10.1016/j.jvoice.2015.08.022.
[31] Tibbetts KM, Simpson CB. Office-based 532-nanometer pulsed potassium-titanyl-phosphate laser procedures in laryngology[J]. Otolaryngol Clin North Am, 2019, 52(3): 537-557. doi:10.1016/j.otc.2019.02.011.
[32] Araki K, Tomifuji M, Uno K, et al. Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions[J]. Auris Nasus Larynx, 2019, 46(5): 772-778. doi:10.1016/j.anl.2019.01.008.
[33] Madden LL, Ward J, Ward A, et al. A cardiovascular prescreening protocol for unmonitored in-office laryngology procedures[J]. Laryngoscope, 2017, 127(8): 1845-1849. doi:10.1002/lary.26481.
[34] Weinstein GS, O'Malley Jr BW, Hockstein NG. Transoral robotic surgery: supraglottic laryngectomy in a canine model[J]. Laryngoscope, 2005, 115(7): 1315-1319. doi:10.1097/01.MLG.0000170848.76045.47.
[35] de Virgilio A, Iocca O, Malvezzi L, et al. The emerging role of robotic surgery among minimally invasive surgical approaches in the treatment of hypopharyngeal carcinoma: systematic review and meta-analysis[J]. J Clin Med, 2019, 8(2): 256. doi:10.3390/jcm8020256.
[36] Tan Wen Sheng B, Wong P, Teo Ee Hoon C. Transoral robotic excision of laryngeal papillomas with Flex® Robotic System: a novel surgical approach[J]. Am J Otolaryngol, 2018, 39(3): 355-358. doi:10.1016/j.amjoto.2018.03.011.
[37] Rey Caro EP, Rey Caro DG, Rey Caro EA. High radiofrequency surgery and chromoendoscopy: a novel surgical technique for the treatment of respiratory papillomatosis[J]. J Voice, 2020. doi:10.1016/j.jvoice.2020.03.021.
[38] Jackowska J, Klimza H, Winiarski P, et al. The usefulness of narrow band imaging in the assessment of laryngeal papillomatosis[J]. PLoS One, 2018, 13(10): e0205554. doi:10.1371/journal.pone.0205554.
[39] Benboujja F, Hartnick C. Clinical and surgical implications of intraoperative optical coherence tomography imaging for benign pediatric vocal fold lesions[J]. Int J Pediatr Otorhinolaryngol, 2018, 114: 111-119. doi:10.1016/j.ijporl.2018.08.036.
[40] Benboujja F, Bowe S, Boudoux C, et al. Utility of optical coherence tomography for guiding laser therapy among patients with recurrent respiratory papillomatosis[J]. JAMA Otolaryngol Head Neck Surg, 2018, 144(9): 831-837. doi:10.1001/jamaoto.2018.1375.
[41] Zhou CY, Sun BC, Wang F, et al. Coblation plus photodynamic therapy(PDT)for the treatment of juvenile onset laryngeal papillomatosis: case reports[J]. World J Surg Oncol, 2014, 12: 275. doi:10.1186/1477-7819-12-275.
[42] Reyes LM, Aguilar JL, Villamor P, et al. Clinical and sociodemographic characteristics associated with disease severity in juvenile recurrent respiratory papillomatosis: a study of 104 patients in a tertiary care pediatric hospital[J]. Int J Pediatr Otorhinolaryngol, 2018, 108: 63-66. doi:10.1016/j.ijporl.2018.02.025.
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