中心型肥胖与头颈癌的关系

doi:10.6040/j.issn.1673-3770.0.2021.137

摘要/Abstract

摘要： 随着全球超重人口数量和比例不断增加,肥胖已成为全球最严重的卫生保健问题之一。肥胖不仅与高血压、高脂血症、糖尿病、胰岛素抵抗等多种疾病关系密切,而且与头颈癌发生的高风险和高死亡率之间可能存在因果关系。重点综述中心型肥胖与头颈癌之间的关系,以及头颈癌患者脂质代谢异常的分子机制,为未来将肥胖作为临床预防头颈癌的新靶点提供新思路。

关键词: 中心型肥胖, 头颈癌, 高脂饮食, 体质量指数, 脂质代谢异常

Abstract: With the increasing number and proportion of obese and overweight people worldwide, obesity has become one of the most globally serious health care problems. Obesity has also been thought to be the cause of many diseases, including hypertension, hyperlipemia, diabetes and insulin resistance. Interestingly, a high risk and mortality rate in head and neck cancer patients have been associated with obesity. Thus, this review focused on the relationship between obesity and head and neck cancer, investigating the molecular mechanism of abnormal lipid metabolism in these patients. Therefore, preventive obesity may be as a new insight in the management of patients with head and neck cancer.

Key words: Central Obesity, Head and neck cancer, High-fat diet, Body mass index, Abnormal lipid metabolism

中图分类号:

R739.91

李超友,王安洋，薛刚. 中心型肥胖与头颈癌的关系[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 120-125.

LI Chaoyou, WANG Anyang,XUE Gang. The relationship between central obesity and head and neck cancer[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 120-125.

参考文献

[1] Reyes-Gibby CC, Melkonian SC, Hanna EY, et al. Cohort study of oncologic emergencies in patients with head and neck cancer[J]. Head Neck, 2017, 39(6): 1195-1204. doi:10.1002/hed.24748.
[2] 马小雨,边晓敏,于丹. 单羧酸转运蛋白家族与头颈部鳞状细胞癌的研究进展[J]. 山东大学耳鼻喉眼学报,2021, 35(2):125-130. doi:10.6040/j.issn.1673-3770.0.2020.196. MA Xiaoyu, BIAN Xiaomin, YU Dan. Advances in understanding the roles of monocarboxylate transporters in head and neck squamous cell carcinoma[J]. Journal of Otorhinolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 125-130. doi:10.6040/j.issn.1673-3770.0.2020.196.
[3] SU YJ, DONG CP, SANG HK, et al. Role of obesity in otorhinolaryngologic diseases[J]. Curr Allergy Asthma Rep, 2019, 19(7): 34. doi: 10.1007/s11882-019-0865-3.
[4] Chen YJ, Lee YCA, Li S, et al. Body mass index and the risk of head and neck cancer in the Chinese population[J]. Cancer Epidemiol, 2019, 60: 208-215. doi:10.1016/j.canep.2019.04.008.
[5] Ward HA, Wark PA, Muller DC, et al. Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition[J]. Cancer Epidemiol Biomarkers Prev, 2017, 26(6): 895-904. doi:10.1158/1055-9965.epi-16-0886.
[6] Jiang H, Zhou L, He Q, et al. The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study[J]. Cancer Metab, 2021, 9(1): 25. doi:10.1186/s40170-021-00261-w.
[7] Recalde M, Davila-Batista V, Díaz Y, et al. Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain[J]. BMC Med, 2021, 19(1): 10. doi:10.1186/s12916-020-01877-3.
[8] Wang H, Wang P, Wu Y, et al. Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: a retrospective study[J]. Peer J, 2020, 8: e9675. doi:10.7717/peerj.9675.
[9] Feng JW, Yang XH, Wu BQ, et al. Influence of body mass index on the clinicopathologic features of papillary thyroid carcinoma[J]. Ann Otol Rhinol Laryngol, 2019, 128(7): 625-632. doi:10.1177/0003489419834314.
[10] Argirion I, Arthur AE, Zarins KR, et al. Pretreatment dietary patterns, serum carotenoids and tocopherols influence tumor immune response in head and neck squamous cell carcinoma[J]. Nutr Cancer, 2020: 1-13. doi:10.1080/01635581.2020.1842895.
[11] Zamani SA, McClain KM, Graubard BI, et al. Dietary polyunsaturated fat intake in relation to head and neck, esophageal, and gastric cancer incidence in the national institutes of health-AARP diet and health study[J]. Am J Epidemiol, 2020, 189(10): 1096-1113. doi:10.1093/aje/kwaa024.
[12] Wang K, Yu XH, Tang YJ, et al. Obesity: an emerging driver of head and neck cancer[J]. Life Sci, 2019, 233: 116687. doi:10.1016/j.lfs.2019.116687.
[13] Lee HC, Liang A, Lin YH, et al. Low dietary n-6/n-3 polyunsaturated fatty acid ratio prevents induced oral carcinoma in a hamster pouch model[J]. Prostaglandins Leukot Essent Fatty Acids, 2018, 136: 67-75. doi:10.1016/j.plefa.2017.03.003.
[14] Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, et al. Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2[J]. Carcinogenesis, 2013, 34(12): 2716-2725. doi:10.1093/carcin/bgt257.
[15] Solís-Martínez O, Plasa-Carvalho V, Phillips-Sixtos G, et al. Effect of eicosapentaenoic acid on body composition and inflammation markers in patients with head and neck squamous cell cancer from a public hospital in Mexico[J]. Nutr Cancer, 2018, 70(4): 663-670. doi:10.1080/01635581.2018.1460678.
[16] Shivappa N, Hébert JR, Zucchetto A, et al. Increased risk of nasopharyngeal carcinoma with increasing levels of diet-associated inflammation in an Italian case-control study[J]. Nutr Cancer, 2016, 68(7): 1123-1130. doi:10.1080/01635581.2016.1216137.
[17] Xu WH, Hu XX, Anwaier A, et al. Fatty acid synthase correlates with prognosis-related abdominal adipose distribution and metabolic disorders of clear cell renal cell carcinoma[J]. Front Mol Biosci, 2021, 25(1): 610229. doi: 10.3389/fmolb.2020.610229.
[18] Hirai H, Tada Y, Nakaguro M, et al. The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma[J]. Virchows Arch, 2020, 477(2): 291-299. doi:10.1007/s00428-020-02777-w.
[19] Su YW, Wu PS, Lin SH, et al. Prognostic value of the overexpression of fatty acid metabolism-related enzymes in squamous cell carcinoma of the head and neck[J]. Int J Mol Sci, 2020, 21(18): 6851. doi:10.3390/ijms21186851.
[20] Wisniewski DJ, Ma T, Schneider A. Nicotine induces oral dysplastic keratinocyte migration via fatty acid synthase-dependent epidermal growth factor receptor activation[J]. Exp Cell Res, 2018, 370(2): 343-352. doi:10.1016/j.yexcr.2018.06.036.
[21] de Aquino IG, Bastos DC, Cuadra-Zelaya FJM, et al. Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines[J]. Arch Oral Biol, 2020, 113: 104707. doi:10.1016/j.archoralbio.2020.104707.
[22] Walz JZ, Saha J, Arora A, et al. Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma[J]. Vet Comp Oncol, 2018, 16(1): E99-E108. doi:10.1111/vco.12341.
[23] Xiao X, Liu H, Li X. Orlistat treatment induces apoptosis and arrests cell cycle in HSC-3 oral cancer cells[J]. Microb Pathog, 2017, 112: 15-19. doi:10.1016/j.micpath.2017.09.001.
[24] McKillop IH, Girardi CA, Thompson KJ. Role of fatty acid binding proteins(FABPs)in cancer development and progression[J]. Cell Signal, 2019, 62: 109336. doi:10.1016/j.cellsig.2019.06.001.
[25] 张雨, 刘芳. FABP4在肿瘤发生发展的初步研究进展[J]. 中国生育健康杂志, 2020, 31(6): 577-579. doi:10.3969/j.issn.1671-878X.2020.06.020.
[26] Fang LY, Wong TY, Chiang WF, et al. Fatty-acid-binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma[J]. J Oral Pathol Med, 2010, 39(4): 342-348. doi:10.1111/j.1600-0714.2009.00836.x.
[27] Ohyama Y, Kawamoto Y, Chiba T, et al. Differential expression of fatty acid-binding proteins and pathological implications in the progression of tongue carcinoma[J]. Mol Clin Oncol, 2014, 2(1): 19-25. doi:10.3892/mco.2013.198.
[28] Lee D, Wada K, Taniguchi Y, et al. Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma[J]. Oncol Rep, 2014, 31(3): 1116-1120. doi:10.3892/or.2014.2975.
[29] Chen J, Cao H, Lian M, et al. Five genes influenced by obesity may contribute to the development of thyroid cancer through the regulation of insulin levels[J]. Peer J, 2020, 8: e9302. doi:10.7717/peerj.9302.
[30] 田晓婷. 未分化型甲状腺癌CRABP-Ⅱ和FABP5的表达失衡及其与维甲酸耐药性相关性研究[D]. 大连: 大连医科大学, 2018. doi: CNKI:CDMD:2.1018.183865.
[31] Wu N, Sarna LK, Hwang SY, et al. Activation of 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)reductase during high fat diet feeding[J]. Biochim Biophys Acta, 2013, 1832(10): 1560-1568. doi:10.1016/j.bbadis.2013.04.024.
[32] Kao LT, Hung SH, Kao PF, et al. Inverse association between statin use and head and neck cancer: Population-based case-control study in Han population[J]. Head Neck, 2019, 41(5): 1193-1198. doi:10.1002/hed.25501.
[33] Gupta A, Stokes W, Eguchi M, et al. Statin use associated with improved overall and cancer specific survival in patients with head and neck cancer[J]. Oral Oncol, 2019, 90: 54-66. doi:10.1016/j.oraloncology.2019.01.019.
[34] Dongoran RA, Wang KH, Lin TJ, et al. Anti-proliferative effect of statins is mediated by DNMT1 inhibition and p21 expression in OSCC cells[J]. Cancers, 2020, 12(8): 2084. doi:10.3390/cancers12082084.
[35] Askari M, Darabi M, Zare Mahmudabadi R, et al. Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma[J]. Clin Transl Oncol, 2015, 17(5): 378-383. doi:10.1007/s12094-014-1242-2.
[36] Chovatiya GL, Sunkara RR, Roy S, et al. Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer[J]. EBioMedicine, 2019, 48: 364-376. doi:10.1016/j.ebiom.2019.08.053.
[37] De Rosa A, Monaco ML, Capasso M, et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects[J]. Eur J Endocrinol, 2013, 169(1): 37-43. doi:10.1530/EJE-12-1039.
[38] Hano K, Hatano K, Saigo C, et al. An adiponectin paralog protein, CTRP6 decreased the proliferation and invasion activity of oral squamous cell carcinoma cells: possible interaction with laminin receptor pathway[J]. Mol Biol Rep, 2019,46(5): 4967-4973. doi:10.1007/s11033-019-04947-9.
[39] Young MR, Levingston C, Johnson SD. Cytokine and adipokine levels in patients with premalignant oral lesions or in patients with oral cancer who did or did not receive 1α, 25-dihydroxyvitamin D3 treatment upon cancer diagnosis[J]. Cancers(Basel), 2015, 7(3): 1109-1124. doi:10.3390/cancers7030827.
[40] da Rocha RG, Santos EMS, Santos EM, et al. Leptin impairs the therapeutic effect of ionizing radiation in oral squamous cell carcinoma cells[J]. J Oral Pathol Med, 2019, 48(1): 17-23. doi:10.1111/jop.12786.
[41] Sobrinho Santos EM, Guimarães TA, Santos HO, et al. Leptin Acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma[J]. Tumour Biol, 2017, 39(5): 1010428317699130. doi:10.1177/1010428317699130.
[42] Gallina S, Sireci F, Lorusso F, et al. The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma[J]. Acta Otorhinolaryngol Ital, 2015, 35(1): 15-22. PMID:26015646
[43] Marcello MA, Calixto AR, de Almeida JF, et al. Polymorphism in LEP and LEPR may modify leptin levels and represent risk factors for thyroid cancer[J]. Int J Endocrinol, 2015: 173218. doi:10.1155/2015/173218.
[44] Tzanavari T, Tasoulas J, Vakaki C, et al. The role of adipokines in the establishment and progression of head and neck neoplasms[J]. Curr Med Chem, 2019, 26(25): 4726-4748. doi:10.2174/0929867325666180713154505.
[45] Er LK, Wu S, Hsu LA, et al. Pleiotropic associations of RARRES2 gene variants and circulating chemerin levels: potential roles of chemerin involved in the metabolic and inflammation-related diseases[J]. Mediators Inflamm, 2018: 4670521. doi:10.3390/ijms20051174.
[46] Zhang KY, Liu CY, Hua L, et al. Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours[J]. Oral Dis, 2016, 22(7): 630-638. doi:10.1111/odi.12505.
[47] Wang N, Wang QJ, Feng YY, et al. Overexpression of chemerin was associated with tumor angiogenesis and poor clinical outcome in squamous cell carcinoma of the oral tongue[J]. Clin Oral Investig, 2014, 18(3): 997-1004. doi:10.1007/s00784-013-1046-8.
[48] Lu Z, Liang J, He Q, et al. The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma[J]. Clin Sci(Lond), 2019, 133(5): 681-695. doi: 10.1042/CS20181023.
[49] Iyengar NM, Ghossein RA, Morris LG, et al. White adipose tissue inflammation and cancer-specific survival in patients with squamous cell carcinoma of the oral tongue[J]. Cancer, 2016, 122(24): 3794-3802. doi:10.1002/cncr.30251.
[50] 周悦, 闫爽. 肥胖、胰岛素抵抗及IGF-1水平与甲状腺乳头状癌关系的初步研究[J]. 哈尔滨医科大学学报, 2020,54(4): 383-386,391. ZHOU Yue, YAN Shuang. Preliminary study on the relationship between obesity, insulin resistance and IGF-1 level with thyroid papillary carcinoma[J]. J Harbin Med Univ, 2020, 54(4): 383-386,391.

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