山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (1): 140-144.doi: 10.6040/j.issn.1673-3770.0.2021.450
• 综述 • 上一篇
李鹏伟,苏光明,刘江川,穆雅林
LI Pengwei, SU Guangming, LIU Jiangchuan, MU Yalin
摘要: 2型黄斑毛细血管扩张症(MacTel 2)是一种双侧、进展缓慢的视网膜神经退行性疾病,血管病变是其主要特征。光学相干断层扫描血管成像(OCTA)是检测MacTel 2的理想工具。OCTA显示,MacTel 2的毛细血管扩张最早出现在旁中心凹颞侧的深层毛细血管丛,与椭圆体带丢失密切相关。随后出现的旁中心凹血管密度降低最先累及小静脉相邻的毛细血管。而直角小静脉的发展可促进视网膜-脉络膜吻合形成。一部分晚期MacTel 2患者可进展为新生血管,而使用血管内皮生长因子(VEGF)抑制剂对未经治疗的新生血管效果显著。现就OCTA近期在MacTel 2中的应用进行综述。
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[1] Heeren TFC, Chew EY, Clemons T, et al. Macular telangiectasia type 2: visual acuity, disease end stage, and the MacTel area: MacTel project report number 8[J]. Ophthalmology, 2020, 127(11): 1539-1548. doi:10.1016/j.ophtha.2020.03.040 [2] Charbel Issa P, Gillies MC, Chew EY, et al. Macular telangiectasia type 2[J]. Prog Retin Eye Res, 2013, 34: 49-77. doi:10.1016/j.preteyeres.2012.11.002 [3] Gass JD, Blodi BA. Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study[J]. Ophthalmology, 1993, 100(10): 1536-1546. [4] Yannuzzi LA, Bardal AM, Freund KB, et al.Idiopathic macular telangiectasia[J]. Arch Ophthalmol, 2006, 124(4): 450-460. [5] Shinkai A, Saito W, Hashimoto Y, et al. Morphological features of macular telangiectasia type 2 in Japanese patients[J]. Graefes Arch Clin Exp Ophthalmol, 2021, 259(5): 1179-1189. doi:10.1007/s00417-020-04989-x [6] Gonzalez MA, Shechtman D, Haynie JM, et al. Unveiling idiopathic macular telangiectasia: clinical applications of optical coherence tomography angiography[J]. Eur J Ophthalmol, 2017, 27(4): e129-e133. doi:10.5301/ejo.5000984 [7] Bonnin S, Mané V, Couturier A, et al. New insight into the macular deep vascular plexus imaged by optical coherence tomography angiography[J]. Retina, 2015, 35(11): 2347-2352. doi:10.1097/IAE.0000000000000839 [8] Dogan B, Erol MK, Akidan M, et al. Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2[J]. Int Ophthalmol, 2019, 39(10): 2245-2256. doi:10.1007/s10792-018-01060-x [9] Pauleikhoff D, Pauleikhoff L, Chew EY. Imaging endpoints for clinical trials in MacTel type 2[J]. Eye(Lond), 2022, 36(2): 284-293. doi:10.1038/s41433-021-01723-7 [10] Thorell MR, Zhang QQ, Huang YP, et al. Swept-source OCT angiography of macular telangiectasia type 2[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5): 369-380. doi:10.3928/23258160-20140909-06 [11] Micevych PS, Lee HE, Fawzi AA. Overlap between telangiectasia and photoreceptor loss increases with progression of macular telangiectasia type 2[J]. PLoS One, 2019, 14(10): e0224393. doi:10.1371/journal.pone.0224393 [12] Litts KM, Okada M, Heeren TFC, et al. Longitudinal assessment of remnant foveal cone structure in a case series of early macular telangiectasia type 2[J]. Transl Vis Sci Technol, 2020, 9(4): 27. doi:10.1167/tvst.9.4.27 [13] Zandi R, Song J, Micevych PS, et al. Topographic relationship between telangiectasia and cone mosaic disruption in macular telangiectasia type 2[J]. J Clin Med, 2020, 9(10): E3149. doi:10.3390/jcm9103149 [14] Powner MB, Gillies MC, Zhu MD, et al. Loss of Müller's cells and photoreceptors in macular telangiectasia type 2[J]. Ophthalmology, 2013, 120(11): 2344-2352. doi:10.1016/j.ophtha.2013.04.013 [15] Gantner ML, Eade K, Wallace M, et al. Serine and lipid metabolism in macular disease and peripheral neuropathy[J]. N Engl J Med, 2019, 381(15): 1422-1433. doi:10.1056/NEJMoa1815111 [16] Chidambara L, Gadde SGK, Yadav NK, et al. Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography[J]. Br J Ophthalmol, 2016, 100(11): 1482-1488. doi:10.1136/bjophthalmol-2015-307941 [17] Ishibazawa A, de Pretto LR, Alibhai AY, et al. Retinal nonperfusion relationship to arteries or veins observed on widefield optical coherence tomography angiography in diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2019, 60(13): 4310-4318. doi:10.1167/iovs.19-26653 [18] Micevych PS, Soetikno BT, Fawzi AA. Perivenular capillary loss: an early, quantifiable change in macular telangiectasia type 2[J]. Transl Vis Sci Technol, 2020, 9(4): 5. doi:10.1167/tvst.9.4.5 [19] Tzaridis S, Heeren T, Mai C, et al. Right-angled vessels in macular telangiectasia type 2[J]. Br J Ophthalmol, 2021, 105(9): 1289-1296. doi:10.1136/bjophthalmol-2018-313364 [20] Breazzano MP, Yannuzzi LA, Spaide RF. Genesis of retinal-choroidal anastomosis in macular telangiectasia type 2: a longitudinal analysis[J]. Retina, 2021, 41(3): 464-470. doi:10.1097/IAE.0000000000002986 [21] Spaide RF, Marco RD, Yannuzzi LA. Vascular distortion and dragging related to apparent tissue contraction in macular telangiectasis type 2[J]. Retina, 2018, 38(Suppl 1): S51-S60. doi:10.1097/IAE.0000000000001694 [22] Zhang QQ, Wang RK, Chen CL, et al. Swept source optical coherence tomography angiography of neovascular macular telangiectasia type 2[J]. Retina, 2015, 35(11): 2285-2299. doi:10.1097/IAE.0000000000000840 [23] Spaide RF, Yannuzzi LA, Maloca PM. Retinal-choroidal anastomosis in macular telangiectasia type 2[J]. Retina, 2018, 38(10): 1920-1929. doi:10.1097/IAE.0000000000002289 [24] Chung YR, Kim YH, Oh J, et al. Characterizing right-angled vessel in macular telangiectasia type 2 with structural optical coherence tomography[J]. Sci Rep, 2021, 11: 17198. doi:10.1038/s41598-021-96789-4 [25] Simone Tzaridis, Kristina Hess, Martin Friedlander, et al. Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2[J]. Br J Ophthalmol, 2020, 105(5): bjophthalmol-2020. doi:10.1136/bjophthalmol-2020-316021 [26] Spaide RF, Klancnik JM Jr, Cooney MJ, et al. Volume-rendering optical coherence tomography angiography of macular telangiectasia type 2[J]. Ophthalmology, 2015, 122(11): 2261-2269. doi:10.1016/j.ophtha.2015.07.025 [27] Singh SR, Fraser-Bell S, Dogra A, et al. Optical coherence tomography angiography findings of fellow eye of proliferative macular telangiectasia type 2: long term study[J]. Eur J Ophthalmol, 2021, 31(4): 1933-1939. doi:10.1177/1120672120939505 [28] Reichenbach A, Bringmann A. Glia of the human Retina[J]. Glia, 2020, 68(4): 768-796. doi:10.1002/glia.23727 [29] Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects[J]. Arch Ophthalmol, 2003, 121(4): 547-557. doi:10.1001/archopht.121.4.547 [30] Jorge R, Costa RA, Calucci D, et al. Intravitreal bevacizumab(Avastin)associated with the regression of subretinal neovascularization in idiopathic juxtafoveolar retinal telangiectasis[J]. Graefes Arch Clin Exp Ophthalmol, 2007, 245(7): 1045-1048. doi:10.1007/s00417-006-0468-2 [31] Thorell MR, Zhang QQ, Huang YP, et al. Swept-source OCT angiography of macular telangiectasia type 2[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5): 369-380. doi:10.3928/23258160-20140909-06 [32] Charbel Issa P, Kupitz EH, Heeren TFC, et al. Treatment for macular telangiectasia type 2[J]. Dev Ophthalmol, 2016, 55: 189-195. doi:10.1159/000431263 [33] Tzaridis S, Wintergerst MWM, Mai C, et al. Quantification of retinal and choriocapillaris perfusion in different stages of macular telangiectasia type 2[J]. Invest Ophthalmol Vis Sci, 2019, 60(10): 3556-3562. doi:10.1167/iovs.19-27055 [34] 张昕雨, 雷春燕, 张美霞. 运用OCT及OCTA观察硅油对视网膜脉络膜的影响[J]. 山东大学耳鼻喉眼学报, 2021, 35(5): 132-136. doi: 10.6040/j.issn.1673-3770.0.2020.539 ZHANG Xinyu, LEI Chunyan, ZHANG Meixia. Retinochoriodal changes associated with silicone oil tamponade detected by optical coherence tomography and optical coherence tomography angiography[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 132-136. doi: 10.6040/j.issn.1673-3770.0.2020.539 |
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