基于CiteSpace近10年单纯疱疹病毒性角膜炎的可视化分析

doi:10.6040/j.issn.1673-3770.0.2023.495

摘要/Abstract

摘要： 目的通过可视化分析揭示单纯疱疹病毒性角膜炎(herpes simplex virus keratitis, HSK)近十年的研究概况,分析该领域的研究热点与趋势。方法检索2013年1月至2022年12月收录于中国知网、万方和维普数据库的HSK相关中文文献,采用CiteSpace软件对相关文献的年发文量、作者、机构和关键词进行分析,绘制并解读各图谱以揭示该领域研究热点与趋势。结果研究最终纳入608篇文献,发文量呈下降趋势,发文量最多的作者是俞莹(7篇);以中国中医科学院眼科医院机构为高产机构(11篇);从关键词分析得出,研究主要集中在单纯疱疹病毒和单纯疱疹病毒性角膜炎的发病机制、症状、临床治疗方案、疾病复发及预后等方面。结论研究明确了国内单纯疱疹病毒性角膜炎领域比较有影响力作者及机构,概括现有研究热点;新型疾病检测诊断方式、探索更多有效的治疗方式及更有价值的药物制剂、合理用药及规避不良反应的发生可能是今后的研究方向。

关键词: 单纯疱疹病毒性角膜炎, CiteSpace, 可视化分析, 中西医结合, 聚星障

Abstract: Objective To reveal the research overview of herpes simplex virus keratitis(HSK)in the past decade through visual analysis and to analyze the research hotspots and trends in this field. Methods Retrieve HSK related Chinese literature collected from CNKI, Wanfang, and VIP databases from January 2013 to December 2022. Use CiteSpace software to analyze the volume of annual publication, authors, institutions, and keywords from the relevant literature. Draw and interpret various graphs to reveal research hotspots and trends in this field. Results 608 articles were finally included, with a decreasing trend in the volume of publications. The author with the highest number of publications was Yu Ying(7 articles); the Chinese Academy of Traditional Chinese Medicine Ophthalmology Hospital as a high-yield institution(11 articles); From the keyword analysis, it can be concluded that research focuses mainly on the pathogenesis and symptoms of herpes simplex virus and herpes simplex keratitis, clinical treatment options, disease recurrence and prognosis. Conclusion The study identified influential authors and institutions in the field of herpes simplex keratitis in China, summarized existing research hotspots; Novel ways of detecting and diagnosing the disease, exploring more effective treatment methods and more valuable drug formulations, rationalizing the use of medication, and avoiding adverse reactions may be future research directions.

Key words: Herpes simplex virus keratitis, CiteSpace, Visualization analysis, Integration of traditional Chinese and Western medicine, Multiple star barrier

中图分类号:

R772.2

王紫燕,王方. 基于CiteSpace近10年单纯疱疹病毒性角膜炎的可视化分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 108-115.

WANG Ziyan, WANG Fang. Visualization analysis of herpes simplex virus keratitis based on CiteSpace in the past decade[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 108-115.

参考文献

[1] Corey L, Huang ML, Selke S, et al. Differentiation of herpes simplex virus types 1 and 2 in clinical samples by a real-time taqman PCR assay[J]. J Med Virol, 2005, 76(3): 350-355. doi:10.1002/jmv.20365
[2] Souza PM, Holland EJ, Huang AJ. Bilateral herpetic keratoconjunctivitis[J]. Ophthalmology, 2003, 110(3): 493-496. doi:10.1016/S0161-6420(02)01772-4
[3] 谢鹏飞, 霍勤. 中医药治疗单纯疱疹病毒性角膜炎的进展[J]. 中国中医药现代远程教育, 2019, 17(16): 141-144. doi:10.3969/j.issn.1672-2779.2019.16.056 XIE Pengfei, HUO Qin. Progress of traditional Chinese medicine in the treatment of herpes simplex viral keratitis[J]. Chinese Medicine Modern Distance Education of China, 2019, 17(16): 141-144. doi:10.3969/j.issn.1672-2779.2019.16.056
[4] 康慧颖, 曹启江, 张朔, 等. 单纯疱疹病毒性角膜炎治疗方法研究进展[J]. 传染病信息, 2021, 34(4): 365-369. doi:10.3969/j.issn.1007-8134.2021.04.019 KANG Huiying, CAO Qijiang, ZHANG Shuo, et al. Research progress in herpes simplex keratitis treatment[J]. Infectious Disease Information, 2021, 34(4): 365-369. doi:10.3969/j.issn.1007-8134.2021.04.019
[5] 任艳莉. 我国机构知识库研究文献可视化分析研究[J]. 图书馆工作与研究, 2020(S1): 16-22. doi:10.16384/j.cnki.lwas.2020.s1.004 REN Yanli. Research on visualization analysis of institutional repository research literature in China[J]. Library Work and Study, 2020(S1): 16-22. doi:10.16384/j.cnki.lwas.2020.s1.004
[6] 陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253. doi:10.16192/j.cnki.1003-2053.2015.02.009 CHEN Yue, CHEN Chaomei, LIU Zeyuan, et al. The methodology function of Cite Space mapping knowledge domains[J]. Studies in Science of Science, 2015, 33(2): 242-253. doi:10.16192/j.cnki.1003-2053.2015.02.009
[7] 李丹, 陈腾宇, 黄演芬, 等. 国内嗅觉障碍相关研究: 基于Citespace的可视化分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 40-48. doi:10.6040/j.issn.1673-3770.0.2021.349 LI Dan, CHEN Tengyu, HUANG Yanfen, et al. Research in the field of olfactory disorders in China-an analysis based on Citespace[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 40-48. doi:10.6040/j.issn.1673-3770.0.2021.349
[8] 关瑞娟, 亢泽峰, 李凌, 等. 益气解毒中药对复发性单纯疱疹病毒性角膜炎HSV-1再活化抑制作用的研究[J]. 中国实用眼科杂志, 2014, 32(4): 466-470. doi:10.3760/cma.j.issn.1006-4443.2014.04.017 GUAN Ruijuan, KANG Zefeng, LI Ling, et al. Research about traditional Chinese medicine of Yiqi detoxification inhibit HSV-1DNA reactivation of herpes simplex keratitis[J]. Chinese Journal of Practical Ophthalmology, 2014, 32(4): 466-470. doi:10.3760/cma.j.issn.1006-4443.2014.04.017
[9] 俞莹, 缪晚虹, 赵芳, 等. 单纯疱疹病毒性角膜炎兔角膜表面温度的改变与角膜损伤关系的研究[J]. 中华实验和临床病毒学杂志, 2016, 30(1): 19-22. doi:10.3760/cma.j.issn.1003-9279.2016.01.005 YU Ying, MIAO Wanhong, ZHAO Fang, et al. Research of cornea superficial temperature in herpes simplex keratitis and its relationship with cornea lesion[J]. Chinese Journal of Experimental and Clinical Virology, 2016, 30(1): 19-22. doi:10.3760/cma.j.issn.1003-9279.2016.01.005
[10] 肖书毓, 陶津华, 王蕾蕾, 等. 基于热、药分离方式的明目解毒方熏蒸对兔单纯疱疹病毒性角膜炎影响的实验研究[J]. 上海中医药杂志, 2021, 55(1): 66-71. doi:10.16305/j.1007-1334.2021.2003065 XIAO Shuyu, TAO Jinhua, WANG Leilei, et al. Effect of Mingmu Jiedu Prescription fumigation on herpes simplex keratitis in rabbits based on heat and drug separation[J]. Shanghai Journal of Traditional Chinese Medicine, 2021, 55(1): 66-71. doi:10.16305/j.1007-1334.2021.2003065
[11] 郑嘉琦, 王蕾蕾, 俞莹. 明目解毒方熏蒸对单纯疱疹病毒性角膜炎HSV-1及角膜CD4、CD14的影响[J]. 中国中医眼科杂志, 2020, 30(6): 386-391. doi:10.13444/j.cnki.zgzyykzz.2020.06.002 ZHENG Jiaqi, WANG Leilei, YU Ying. Effect of Fuming and steaming with Mingmu Jiedu formula on HSV-1, CD4 and CD14 of herpes simplex keratitis[J]. China Journal of Chinese Ophthalmology, 2020, 30(6): 386-391. doi:10.13444/j.cnki.zgzyykzz.2020.06.002
[12] 王珍, 梁丽娜, 马群英, 等. 双秦眼用凝胶对复发性单疱病毒性角膜炎小鼠的干预研究[J]. 中国中医眼科杂志, 2022, 32(9): 684-690. doi:10.13444/j.cnki.zgzyykzz.2022.09.003 WANG Zhen, LIANG Lina, MA Qunying, et al. Intervention of Shuangqin ophthalmic gel on mice with recurrent herpes simplex keratitis[J]. China Journal of Chinese Ophthalmology, 2022, 32(9): 684-690. doi:10.13444/j.cnki.zgzyykzz.2022.09.003
[13] 梁丽娜, 唐由之, 周尚昆, 等. 双秦眼用凝胶对家兔眼部刺激性及抗单疱病毒性角膜炎作用[J]. 中国实验方剂学杂志, 2013, 19(22): 236-239. doi:10.11653/syfj2013220236 LIANG Lina, TANG Youzhi, ZHOU Shangkun, et al. Eye irritation and anti-herpes simplex keratitis effect of Shuangqin ophthalmic gel in rabbit[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2013, 19(22): 236-239. doi:10.11653/syfj2013220236
[14] 王珍, 梁丽娜, 白昱旸, 等. 双秦眼用凝胶对小鼠单疱病毒性角膜炎的干预作用及三叉神经节内LAT表达的影响[J]. 中华中医药杂志, 2014, 29(5): 1657-1660 WANG Zhen, LIANG Lina, BAI Yuyang, et al. Intervention of Shuangqin eye gel on herpes simplex keratitis in experimental mice and the influence of the LAT expressing in the TG[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2014, 29(5): 1657-1660
[15] Rolinski J, Hus I. Immunological aspects of acute and recurrent herpes simplex keratitis[J]. J Immunol Res, 2014, 2014: 513560. doi:10.1155/2014/513560
[16] 杨培增, 范先群. 眼科学[M]. 9版. 北京: 人民卫生出版社, 2018: 114-115
[17] Harris KD. Herpes simplex virus keratitis[J]. Home Healthc Now, 2019, 37(5): 281-284. doi:10.1097/NHH.0000000000000791
[18] 张宇, 任胜卫. 单纯疱疹病毒性角膜基质炎角膜新生血管的研究进展[J]. 中华眼科杂志, 2019, 55(12): 956-960. doi:10.3760/cma.j.issn.0412-4081.2019.12.017 ZHANG Yu, REN Shengwei. Research progress of corneal neovascularization in herpes stromal keratitis[J]. Chinese Journal of Ophthalmology, 2019, 55(12): 956-960. doi:10.3760/cma.j.issn.0412-4081.2019.12.017
[19] 费惠英, 谢育霞, 魏传峰, 等. 益气解毒冲剂对单纯疱疹病毒性角膜炎的临床疗效[J]. 世界中医药, 2020, 15(22): 3455-3457. doi:10.3969/j.issn.1673-7202.2020.22.018 FEI Huiying, XIE Yuxia, WEI Chuanfeng, et al. Clinical effect of Yiqi Jiedu Granule on herpes simplex keratitis[J]. World Chinese Medicine, 2020, 15(22): 3455-3457. doi:10.3969/j.issn.1673-7202.2020.22.018
[20] Rajasagi NK, Rouse BT. The role of T cells in herpes stromal keratitis[J]. Front Immunol, 2019, 10: 512. doi:10.3389/fimmu.2019.00512
[21] Kausar S, Said Khan F, Ishaq Mujeeb Ur Rehman M, et al. A review: mechanism of action of antiviral drugs[J]. Int J Immunopathol Pharmacol, 2021, 35: 20587384211002621. doi:10.1177/20587384211002621
[22] 张彩玲, 温伟添. 更昔洛韦滴眼液联合小剂量糖皮质激素治疗单纯疱疹病毒性角膜炎的临床疗效[J]. 临床合理用药杂志, 2022, 15(30): 145-148. doi:10.15887/j.cnki.13-1389/r.2022.30.043 ZHANG Cailing, WEN Weitian. Clinical efficacy of ganciclovir eye drops combined with low dose glucocorticoid in the treatment of herpes simplex keratitis[J]. Chinese Journal of Clinical Rational Drug Use, 2022, 15(30): 145-148. doi:10.15887/j.cnki.13-1389/r.2022.30.043
[23] 钟玉生. 伐昔洛韦联合干扰素α-2b治疗单纯疱疹病毒性角膜炎的效果及安全性[J]. 临床医学研究与实践, 2021, 6(23): 101-103. doi:10.19347/j.cnki.2096-1413.202123033 ZHONG Yusheng. Effect and safety of valaciclovir combined with interferon α-2b in the treatment of herpes simplex keratitis[J]. Clinical Research and Practice, 2021, 6(23): 101-103. doi:10.19347/j.cnki.2096-1413.202123033
[24] 鲁士友, 宿艳. 龙胆泻肝汤加减联合针灸治疗肝火炽盛证单纯疱疹病毒性角膜炎[J]. 中国实验方剂学杂志, 2018, 24(15): 216-221. doi:10.13422/j.cnki.syfjx.20181537 LU Shiyou, SU Yan. Clinical efficacy of addition and subtraction therapy of Longdan Xiegan Tang combined with acupuncture on herpes simplex keratitis(HSK)with syndrome of exuberance of liver fire[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(15): 216-221. doi:10.13422/j.cnki.syfjx.20181537
[25] 孙志毅, 宋继科, 毕宏生. 抑火清肝退翳汤加减治疗肝经风热型单纯疱疹性角膜炎的临床疗效及作用机制[J]. 中国实验方剂学杂志, 2020, 26(11): 124-129. doi:10.13422/j.cnki.syfjx.20201028 SUN Zhiyi, SONG Jike, BI Hongsheng. Clinical efficacy and mechanism of modified yihuo Qinggan Tuiyi Tang in treating herpes simplex keratitis with liver meridian and wind-heat[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2020, 26(11): 124-129. doi:10.13422/j.cnki.syfjx.20201028
[26] 程娟, 李琦, 张红, 等. 除翳解毒方对复发单纯疱疹病毒性角膜炎大鼠模型血清CD4+、CD8+T细胞的影响[J]. 中国中医眼科杂志, 2018, 28(5): 292-296. doi:10.13444/j.cnki.zgzyykzz.2018.05.004 CHENG Juan, LI Qi, ZHANG Hong, et al. Effect of Chuyi Jiedu Decoction on serum CD4+, CD8+T cells in recurrent herpes simplex keratitis rats model[J]. China Journal of Chinese Ophthalmology, 2018, 28(5): 292-296. doi:10.13444/j.cnki.zgzyykzz.2018.05.004
[27] 徐宇明, 张焕英, 欧国平, 等. 单纯疱疹病毒性角膜炎患者采取中药离子导入治疗的效果观察[J]. 中国实用医药, 2018, 13(10): 141-143. doi:10.14163/j.cnki.11-5547/r.2018.10.083 XU Yuming, ZHANG Huanying, OU Guoping, et al. Observation on the effect of iontophoresis of traditional Chinese medicine on herpes simplex keratitis[J]. China Practical Medicine, 2018, 13(10): 141-143. doi:10.14163/j.cnki.11-5547/r.2018.10.083
[28] 江丹, 阮雯洁, 刘新泉. 秦皮汤内服联合低温超声雾化治疗单纯疱疹病毒性角膜炎的临床观察[J]. 辽宁中医杂志, 2019, 46(3): 573-576. doi:10.13192/j.issn.1000-1719.2019.03.039 JIANG Dan, RUAN Wenjie, LIU Xinquan. Therapeutic effects of Qinpi Decoction combined with low temperature ultrasonic atomization on herpes simplex keratitis[J]. Liaoning Journal of Traditional Chinese Medicine, 2019, 46(3): 573-576. doi:10.13192/j.issn.1000-1719.2019.03.039
[29] 吴丽芳, 赵红艳. 针刺结合中西药物综合治疗单纯疱疹病毒性角膜炎临床观察[J]. 浙江中医杂志, 2015, 50(10): 744-746. doi:10.13633/j.cnki.zjtcm.2015.10.029 WU Lifang, ZHAO Hongyan. Clinical observation on comprehensive treatment of herpes simplex keratitis by acupuncture combined with Chinese and Western medicine[J]. Zhejiang Journal of Traditional Chinese Medicine, 2015, 50(10): 744-746. doi:10.13633/j.cnki.zjtcm.2015.10.029
[30] 陈水龄, 陶方方, 宋剑涛, 等. 益气解毒法治疗复发性单纯疱疹病毒性角膜炎临床经验[J]. 北京中医药, 2022, 41(3): 296-297. doi:10.16025/j.1674-1307.2022.03.017 CHEN Shuiling, TAO Fangfang, SONG Jiantao, et al. Clinical experience of treating recurrent herpes simplex keratitis with method for benefiting qi and detoxifying[J]. Beijing Journal of Traditional Chinese Medicine, 2022, 41(3): 296-297. doi:10.16025/j.1674-1307.2022.03.017
[31] 王朱健, 黄霏霏, 龚一帆, 等. 泪液特异性IgA检测诊断单纯疱疹病毒性角膜炎的初步研究[J]. 中国眼耳鼻喉科杂志, 2021, 21(2): 117-119. doi:10.14166/j.issn.1671-2420.2021.02.011 WANG Zhujian, HUANG Feifei, GONG Yifan, et al. Determination of herpes simplex virus specific IgA in tears for diagnosis of herpes simplex keratitis: a preliminary study[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2021, 21(2): 117-119. doi:10.14166/j.issn.1671-2420.2021.02.011
[32] 李娟娟. 更昔洛韦眼药水治疗单疱病毒性角膜炎的临床疗效及不良反应分析[J]. 中国社区医师, 2021, 37(21): 24-25. doi:10.3969/j.issn.1007-614x.2021.21.011 LI Juanjuan. Analysis of clinical efficacy and adverse reactions of ganciclovir ophthalmic water in the treatment of herpes simplex keratitis[J]. Chinese Community Doctors, 2021, 37(21): 24-25. doi:10.3969/j.issn.1007-614x.2021.21.011

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