喉异期喉重复癌

doi:10.6040/j.issn.1673-3770.1.2019.032

摘要/Abstract

摘要： 目的

分析喉癌术后无瘤生存5年以上，喉重复癌病例的临床特征与治疗。

方法

收集近20年来符合以上条件的喉癌患者对初发和再发肿瘤的时间间隔、再发后治疗方式及生存情况进行分析。

结果

1997至2018年患者9例，其中T₁N₀M₀ 3例，T₂N₀M₀ 5例，T₃N₀M₀ 1例。喉癌治疗后喉部重复癌发生最短60个月，最长190个月。喉部重复癌(同侧3例，对侧3例，声门下3例)9例，8例进行了不同方式的二次手术治疗。喉部重复癌确诊后2例死亡，已生存时间15~87个月；其中再手术后生存时间超过3年者5例。

结论

喉癌术后远期治愈后仍有肿瘤再发局部重复癌可能，需坚持长期有效的随访，尽早发现再发病灶并进行处理，仍能延长患者生存期。

关键词: 喉肿瘤, 重复癌, 手术, 预后

Abstract: 目的

分析喉癌术后无瘤生存5年以上，喉重复癌病例的临床特征与治疗。

方法

收集近20年来符合以上条件的喉癌患者对初发和再发肿瘤的时间间隔、再发后治疗方式及生存情况进行分析。

结果

结论

喉癌术后远期治愈后仍有肿瘤再发局部重复癌可能，需坚持长期有效的随访，尽早发现再发病灶并进行处理，仍能延长患者生存期。

Key words: Laryngeal neoplasms, Repeat cancer, Surgery, Prognosis

中图分类号:

R767

黄若飞,陈立晓,陈歆维,於子卫,金斌,祝江才,董频. 喉异期喉重复癌[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 36-39.

Ruofei HUANG,Lixiao CHEN,Xinwei CHEN,Ziwei YU,Bin JIN,Jiangcai ZHU,Pin DONG. Recurrent laryngeal cancer[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 36-39.

参考文献 27

1	Lin YS , Yeh CC , Huang SF , et al. Aspirin associated with risk reduction of secondary primary cancer for patients with head and neck cancer: A population-based analysis[J]. PLoS One, 2018, 13 (8): e0199014. doi: 10.1371/journal.pone.0199014
2	Yamaguchi T , Kato K , Nagashima K , et al. Type of second primary malignancy after achieving complete response by definitive chemoradiation therapy in patients with esophageal squamous cell carcinoma[J]. Int J Clin Oncol, 2018, 23 (4): 652- 658. doi: 10.1007/s10147-018-1258-7
3	李晓艳, 屠理强, 董频, 等. 喉癌和喉咽癌的重复癌临床分析[J]. 上海交通大学学报(医学版), 2007, 27 (9): 1065- 1067, 1087. doi: 10.3969/j.issn.1674-8115.2007.09.008
	LI Xiaoyan , TU Liqiang , DONG Pin , et al. Retrospective analysis of multiple primary malignant tumor in patients with laryngeal and hypopharyngeal carcinoma[J]. J Shanghai Jiaotong Univ Med Sci, 2007, 27 (9): 1065- 1067, 1087. doi: 10.3969/j.issn.1674-8115.2007.09.008
4	Atienza JA , Dasanu CA . Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature[J]. Curr Med Res Opin, 2012, 28 (12): 1899- 1909. doi: 10.1185/03007995.2012.746218
5	Bosetti C , Scelo G , Chuang SC , et al. High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries[J]. Int J Cancer, 2011, 129 (1): 173- 179. doi: 10.1002/ijc.25652
6	Barclay ME , Lyratzopoulos G , Walter FM , et al. Incidence of second and higher order smoking-related primary cancers following lung cancer: a population-based cohort study[J]. Thorax, 2019, 74 (5): 466- 472. doi: 10.1136/thoraxjnl-2018-212456
7	Bunbanjerdsuk S , Vorasan N , Saethang T , et al. Oncoproteomic and gene expression analyses identify prognostic biomarkers for second primary malignancy in patients with head and neck squamous cell carcinoma[J]. Mod Pathol, 2019, 32 (7): 943- 956. doi: 10.1038/s41379-019-0211-2
8	Silén S , Haapaniemi A , Dickinson A , et al. Presentation of second primary cancers in young laryngeal carcinoma patients[J]. Acta Otolaryngol, 2019, 139 (1): 85- 89. doi: 10.1080/00016489.2018.1527037
9	Polednik KM , Simpson MC , Adjei Boakye E , et al. Radiation and second primary thyroid cancer following index head and neck cancer[J]. Laryngoscope, 2019, 129 (4): 1014- 1020. doi: 10.1002/lary.27467
10	Chuang SC , Hashibe M , Scelo G , et al. Risk of second primary cancer among esophageal cancer patients: a pooled analysis of 13 cancer registries[J]. Cancer Epidemiol Biomarkers Prev, 2008, 17 (6): 1543- 1549. doi: 10.1158/1055-9965.EPI-07-2876
11	Chuang SC , Scelo G , Tonita JM , et al. Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries[J]. Int J Cancer, 2008, 123 (10): 2390- 2396. doi: 10.1002/ijc.23798
12	Crippen MM , Brady JS , Burke LA , et al. Second primary lung malignancy following head and neck squamous cell carcinoma[J]. Laryngoscope, 2019, 129 (4): 903- 909. doi: 10.1002/lary.27422
13	Hoban CW , Beesley LJ , Bellile EL , et al. Individualized outcome prognostication for patients with laryngeal cancer[J]. Cancer, 2018, 124 (4): 706- 716. doi: 10.1002/cncr.31087
14	董频, 刘思良, 李克勇, 等. 142例喉癌手术的远期疗效分析[J]. 山东大学耳鼻喉眼学报, 2005, 19 (5): 313- 315. doi: 10.3969/j.issn.1673-3770.2005.05.013
	DONG Pin , LIU Siliang , LI Keyong , et al. Long- term therapeutic effect of surgery on 142 patients with laryngeal carcinoma[J]. J Otolaryngol Ophthalmol Shandong Univ, 2005, 19 (5): 313- 315. doi: 10.3969/j.issn.1673-3770.2005.05.013
15	董频, 王杰, 金斌, 等. 205例喉癌的手术方式与远期疗效分析[J]. 中华耳鼻咽喉头颈外科杂志, 2005, 40 (8): 591- 594. doi: 10.3760/j.issn:1673-0860.2005.08.008
	DONG Pin , WANG Jie , JIN Bin , et al. Surgery on laryngeal carcinoma: retrospective analysis of 205 cases[J]. Chin J Otorhinolaryngol Head Neck Surg, 2005, 40 (8): 591- 594. doi: 10.3760/j.issn:1673-0860.2005.08.008
16	Leoncini E , Vukovic V , Cadoni G , et al. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium[J]. Eur J Epidemiol, 2018, 33 (12): 1205- 1218. doi: 10.1007/s10654-018-0409-5
17	Xing Y , Zhang JJ , Lin H , et al. Relation between the level of lymph node metastasis and survival in locally advanced head and neck squamous cell carcinoma[J]. Cancer, 2016, 122 (4): 534- 545. doi: 10.1002/cncr.29780
18	Hinerman RW , Mendenhall WM , Amdur RJ , et al. Carcinoma of the supraglottic larynx: treatment results with radiotherapy alone or with planned neck dissection[J]. Head Neck, 2002, 24 (5): 456- 467. doi: 10.1002/hed.10069
19	刘业海, 唐平章, 徐震纲, 等. 声门型喉癌部分喉切除术后复发原因探讨及预防[J]. 临床耳鼻咽喉科杂志, 2003, 17 (3): 129- 131. doi: 10.3969/j.issn.1001-1781.2003.03.001
	LIU Yehai , TANG Pingzhang , XU Zhengang , et al. Study of the causes of recurrence of patients with glottic cancer after partial laryngectomy[J]. J Clin Otorhinolaryngol, 2003, 17 (3): 129- 131. doi: 10.3969/j.issn.1001-1781.2003.03.001
20	Morris LGT , Sikora AG , Patel SG , et al. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer[J]. J Clin Oncol, 2011, 29 (6): 739- 746. doi: 10.1200/jco.2010.31.8311
21	Birkeland AC , Rosko AJ , Chinn SB , et al. Prevalence and outcomes of head and neck versus non-head and neck second primary malignancies in head and neck squamous cell carcinoma: an analysis of the surveillance, epidemiology, and end results database[J]. ORL J Otorhinolaryngol Relat Spec, 2016, 78 (2): 61- 69. doi: 10.1159/000443768
22	Lee DH , Roh JL , Baek S , et al. Second cancer incidence, risk factor, and specific mortality in head and neck squamous cell carcinoma[J]. Otolaryngol Head Neck Surg, 2013, 149 (4): 579- 586. doi: 10.1177/0194599813496373
23	Farshadpour F , Kranenborg H , Calkoen EV , et al. Survival analysis of head and neck squamous cell carcinoma: influence of smoking and drinking[J]. Head Neck, 2011, 33 (6): 817- 823. doi: 10.1002/hed.21549
24	伊海金, 张宝泉, 刘丕楠, 等. 喉癌肿瘤标志物和喉癌分子切缘及临床因素与喉癌复发的相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2008, 22 (12): 529- 531. doi: 10.3969/j.issn.1001-1781.2008.12.001
	YI Haijin , ZHANG Baoquan , LIU Peinan , et al. Relative factors analysis including carcinoma marker, molecular margin and clinical factors on laryngeal eaeinoma recurrence[J]. J Clin Otorhinolaryngol Head Neck Surg, 2008, 22 (12): 529- 531. doi: 10.3969/j.issn.1001-1781.2008.12.001
25	Awan MJ , Nedzi L , Wang D , et al. Final results of a multi-institutional phase Ⅱ trial of reirradiation with concurrent weekly cisplatin and cetuximab for recurrent or second primary squamous cell carcinoma of the head and neck[J]. Ann Oncol, 2018, 29 (4): 998- 1003. doi: 10.1093/annonc/mdy018
26	Goodwin WJ Jr . Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means?[J]. Laryngoscope, 2000, 110 (3 Pt 2 Suppl 93): 1- 18. doi: 10.1097/00005537-200003001-00001
27	Zafereo M . Surgical salvage of recurrent cancer of the head and neck[J]. Curr Oncol Rep, 2014, 16 (5): 386. doi: 10.1007/s11912-014-0386-0

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