山东大学耳鼻喉眼学报 ›› 2022, Vol. 36 ›› Issue (4): 114-119.doi: 10.6040/j.issn.1673-3770.1.2021.152

• • 上一篇    

喉神经内分泌癌的研究进展

毛泽凡综述陈曦,程雷审校   

  1. 南京医科大学第一附属医院/江苏省人民医院 耳鼻咽喉科, 江苏 南京 210029;
  • 发布日期:2022-07-11
  • 通讯作者: 陈曦. E-mail:jsxycx@sina.com;程雷. E-mail: chenglei@jsph.org.cn
  • 基金资助:
    江苏高校优势学科建设工程(JX10231801)

Research advances in neuroendocrine carcinoma of the larynx

MAO ZefanOverview,CHEN Xi, CHENG LeiGuidance   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2022-07-11

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246

摘要： 喉神经内分泌癌是一种罕见的起源于上皮型神经内分泌细胞的喉恶性肿瘤,根据分化程度和细胞类型分为4种组织学亚型:典型类癌、非典型类癌、小细胞神经内分泌癌和大细胞神经内分泌癌。不同肿瘤亚型差异很大,由于发病率过低致使这些差异的正确描述一直受到阻碍。因报道过少的病例或无法收集足够的样本量,文献中常常存在相互矛盾的结果,很难形成共同的认知。综述近期的文献资料,就喉神经内分泌癌的临床行为、特点、诊断、治疗及预后等方面进行文献复习,提高临床医生对该病的认识,优化诊治方案。

关键词: 喉肿瘤, 喉神经内分泌癌, 上皮型神经内分泌细胞, 小细胞神经内分泌癌, 大细胞神经内分泌癌

Abstract: Neuroendocrine carcinoma of the larynx is a rare malignant tumor of the larynx that originates from epithelial neuroendocrine cells. Based on the degree of differentiation and cell type, it can be divided into four histological subtypes: typical carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma, and large cell neuroendocrine carcinoma. Despite the substantial differences across these subtypes, an accurate description of their differences has been impeded by the overly low incidence. A number of studies reported are frequently contradictory due to too few cases reported or the inability to collect a sufficient sample size, making it difficult to reach a consensus. This paper reviews the recent literature reports on the clinical behavior, characteristics, diagnosis, treatment, and prognosis of neuroendocrine carcinoma of the larynx, to provide an evidence for clinicians to broaden their understanding and optimize the diagnosis and treatment protocol for this disease.

Key words: Laryngeal neoplasm, Neuroendocrine carcinoma of the larynx, Epithelial neuroendocrine cells, Small cell neuroendocrine carcinoma, Large cell neuroendocrine carcinoma

中图分类号: 

  • R739.65
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