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Animal model of obstructive sleep apnea hypopnea syndrom with hypertension in rats

MU Chao, WANG Yan, LI Yan-zhong   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hosptal of Shandong University, Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, Shandong, China
  • Received:2014-01-15 Online:2014-04-16 Published:2014-04-16
  • Supported by:
    山东省科技攻关计划项目(2008GG10002062)

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Abstract: Objective    To build an animal model of obstructive sleep apnea hypopnea syndrom(OSAHS)with hypertension.  Methods    10 Wistar rats which were injected 1mL Sodium Hyaluronate into the palatoglossal arch, palatopharyngeal arch and root of the tongue of served as the experimental group, and the other 10 Wistar rats as the control group. The electroencephalogram and oro-nasal airflow were recorded by PSG when rats were under anesthesia and measuring arterial systolic pressure (SBP) and OSAHS periodic. Results    ① The experimental group showed differences in apnea index (AI), the longest apnea and the lowest concentration of blood oxygen saturation before and after injection of Sodium Hyaluronate when under light anesthesia (P<0.05); ② SBP in the two groups were insignificant before building the model. The SBP of the experimental group began to rise at 4 weeks and were obvious increased when compared with the control group at 8 weeks (P<0.01). Conclusion    The animal model of OSAHS with hypertension in rats established by injection of Sodium Hyaluronate was steady and credible.

Key words: Hypertension, Wistar rats, Sleep apnea hypopnea syndrome, obstructive, Model

CLC Number: 

  • R766.7
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