Abstract: Objective To evaluate the risk factors of diabetic retinopathy(DR)progression by observing the variation of visual acuity and fundus in type 2 diabetic patients after phacoemulsification and intraocular lens implantation. Methods A total of 50 patients with type 2 diabetes mellitus accompanied by non-proloferative diabetic retinopathy(NPDR)who needed to undergo phacoemulsification and intraocular lens implantation for the single eye were collected as research objects. Operative eyes and non-operatives were respectively as surgery and non-surgery groups. On 1, 7 days and 1, 3 months after surgery, both the best corrected visual acuity(BCVA)and optical coherence tomography(OCT)in macular region were conducted, and fundus fluorescein angiography(FFA)was also performed 3 months after surgery. The DR progression-related risk factors were analyzed. Results The visual acuity in surgery group improved obviously 1 d-3 months after surgery(P<0.01), but BCVA 3 months after surgery had the decreasing trend. The incidence of postoperative macular edema and DR progression rate in surgery group were higher than in non-surgery group, with statistical significance(P<0.05 or P<0.01). Logistic regression analysis research results displayed that glycosylated hemoglobin(OR=21.423), course of diabetes mellitus(OR=9.061)and NPDR degree(OR=2.486)were the risk factors of DR progression. Conclusion The BCVA of patients with NPDR in type 2 diabetes mellitus improves dramatically after phacoemulsification and intraocular lens implantation, but decreases slightly 3 months after surgery. Long course of diabetes mellitus, worse control of blood glucose and preoperative aggravation of DR are the risk factors of postoperative DR progression.

Key words: Type 2 diabetes mellitus, Phacoemulsification, Optical coherence tomography, Best corrected visual acuity, Diabetic retinopathy