JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 81-84.doi: 10.6040/j.issn.1673-3770.0.2015.358

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Research progress of Fascin-2 gene function.

YANG Linlin1,2, SONG Xicheng2, HAN Fengchan1   

  1. 1. Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, Yantai 264003, Shandong, China;2. Department of Otolaryngology &Head and Neck Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, Shandong, China
  • Received:2015-08-22 Online:2016-12-16 Published:2016-12-16

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Abstract: Fascin-2 gene, an actin cross-linking protein found in membrane ruffles, microspikes, and stress fibers, controls the parallel, sequential, and tight alignment and aggregation of actin filaments. Recent researches have found that Fascin-2 gene is associated with the cilia of plasma membrane, whose basic composition is actin; Fascin-2 gene plays an important role in the formation of photoreceptor disk and stereocilia; the mutation of Fascin-2 gene may cause progressive retinitis pigmentosa and hearing loss. This paper will elucidate the latest research progress on Fascin-2 gene.

Key words: Hearing loss, Retinitis pigmentosa, Fascin-2

CLC Number: 

  • R764.4
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