JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 67-69.doi: 10.6040/j.issn.1673-3770.0.2015.433

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Research on diagnosis and treatment of laryngopharyngeal reflux disease.

CHEN Xun1, YANG Yun2, CHEN Zhibin1   

  1. 1. Nanjing Medical University, Nanjing 210029, Jiangsu, China;2. Department of Otolaryngology &Head Neck Surgery, Jiangsu Shengze Hospital, Suzhou 215228, Jiangsu, China
  • Received:2015-10-19 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To discuss the diagnosis and treatment method of laryngopharyngeal reflux disease(LPRD), and to observe the detection rate of helicobacter pylori from the patients with LPRD. Methods A Total of 156 LPRD patients with reflux symptom index(RSI)over 13 and/or reflux symptom index(RFS)>7 were supplied with 13C-Urea Breath Test(13C-UBT). The Hp positive patients(n=96, group I)were administrated with quadruple therapy(Omeprazole+Bismuth Potassium Citrate+Amoxicillin+Clindamycin)and Ganju Bingmei tablets for 2 weeks, followed up with a 4 weeks of withdrawal period. The primary ourcome observed was of Hp negative transformation rate and curative effect evaluation before and after the treatment; Hp negative patients were divided into group II and group III, with 30 cases in each group. The group II was given Ganju Bingmei tablets for 4 weeks and the group III was administrated with Omeprazole+Bismuth Potassium Citrate and Ganju Bingmei Tablets for 4 weeks. The main outcome was LPRD and HP negative-converting rate. Results The Hp negative-converting rate was 78.12%(75/96)in group I. The LPRD negative-converting rate in group I, group II and group III was 67.71%(65/96), 53.33%(16/30)and 96.67%(29/30), respectively.The score of RSI and RFS were decreased in all three groups after treatment, and dropped more significantly in group III(Statistic:6.73,P<0.001). Conclusion Laryngopharyngeal reflux, as an important cause of sphagitis, can be improved by using antiacid and gastrointestinal prokinetic agents.

Key words: Helicobacter pylori, Helicobacter pylori quadruple therapy, Laryngopharyngeal reflux disease, 13C-Urea Breath Test

CLC Number: 

  • R766
[1] 华杜鹃, 屈季宁, 周涛. 反流症状指数量表和反流体征指数量表在喉咽反流性疾病诊断中的应用研究[J]. 中国耳鼻咽喉头颈外科, 2013, 20(3):144-146. HUA Dujuan, QU Jining, ZHOU Tao. Application of reflux symptom index and reflux finding score in the diagnosis of laryngopharyngeal reflux disease[J]. Chin Arch Otolaryngol Head Neck Surg, 2013, 20(3):144-146.
[2] Belafsky P C, Postma G N, Koufman J A. The validity and reliability of the reflux symptom index(RSI)[J]. J Voice, 2002, 16(2):274-277.
[3] Belafsky P C, Postma G N, Koufman J A. The validity and reliability of the reflux finding score(RFS)[J]. Laryngoscope, 2001, 111(8):1313-1317.
[4] Belafsky P C, Postma G N, Amin M R, et al. Symptoms and findings of larygopharyngeal reflux[J]. Ear Nose Throat J, 2002, 81(9 Suppl 2):10-13.
[5] 汪浩, 邹文静. 胃幽门螺杆菌采用不同方法检测结果比较[J]. 世界华人消化杂志, 2015, 23(3):525-529. WANG Hao, ZOU Wenjing. Comparison of different methods for detecting Helicobacter pylori[J]. World Chin J Digestol, 2015, 23(3):525-529.
[6] 刘文忠, 谢勇,成红, 等.第四次全国幽门螺杆菌感染处理共识报告[J]. 胃肠病学, 2012, 17(10):618-623. LIU Wenzhong, XIE Yong, CHENG Hong, et al. The 4th Chinese national consensus report on management of helicobacter pylori infection[J]. Chin J Gastroenterol, 2012, 17(10): 618-623.
[7] 李燕, 郑宏良, 陈斌, 等. 甘桔冰梅片在咽喉反流性疾病治疗中的应用研究[J]. 世界中医药, 2015, 10(1):49-52. LI Yan, ZHENG Hongliang, CHEN Bin, et al. Applied research of ganju bingmei tablets the treatment of laryngopharyngeal reflux[J]. World Chin Med, 2015, 10(1):49-52.
[8] 韩德民. 重视喉咽反流在耳鼻咽喉头颈外科中的作用[J]. 中国医学文摘·耳鼻咽喉科学, 2010, 25(5):234-236. HAN Demin. Effect of Iaryrlgopharyngeal refIux in Department of ENT & HN Surgery[J]. New Reviews, 2010, 25(5):234-236.
[9] Park K H, Choi S M, Kwon S U, et al. Diagnosis of laryngopharyngeal reflux among globus patients[J]. Otolaryngol Head Neck Surg, 2006, 134(1):81-85.
[10] Kotby M N, Hassan O, El-Makhzangy A M, et al. Gastroesophageal reflux/laryngopharyngeal reflux disease: a critical analysis of the literature[J]. Eur Arch Otorhinolaryngol, 2010, 267(2):171-179.
[11] 李进让, 彭莉莉. 喉咽反流性疾病与胃食管反流性疾病[J]. 中国医学文摘·耳鼻咽喉科学, 2010, 25(5):256-258. LI Jinrang, PENG Lili. Laryngopharyngeal and gastroesophageal reflux diseases[J]. New Reviews, 2010, 25(5):256-258.
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