JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 14-17.doi: 10.6040/j.issn.1673-3770.0.2016.105

Previous Articles     Next Articles

Vestibular function damage mechanisms in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy.

LIU Ye1, SUN Dianshui1, YIN Jinjun2, XIA Ming3, XU Ying1, SUN Jianhua1   

  1. 1. Cancer Center, the Second Hospital of Shandong University, Jinan 250033, Shandong, China;2. Cancer Center, Weihai Municipal Hospital, Weihai 264200, Shandong, China;3. Department of Otorhinolaryngology &Head and Neck Surgery, the Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2016-03-13 Online:2016-12-16 Published:2016-12-16

PDF (PC)

489

Abstract: Objective To explore potential mechanisms of vestibular function damage in nasopharyngeal carcinoma(NPC)patients after intensity-modulated radiotherapy(IMRT). Methods Patients who received radical IMRT for their NPC were recruited. The serum levels of IL-6 and IL-17 were detected with ELISA method. Vestibular evoked myogenic potential(VEMP)tests were used to evaluate vestibular function and correlation analyses were used to analyze the potential mechanisms of vestibular function damage. Results Thirty-eight patients were included. The mean and maximum radiation doses to the inner ears were both significantly associated with abnormal ocular VEMP(oVEMP)and cervical VEMP(cVEMP)(P<0.05, all), but the correlations were all mild. There were no significant correlations between otitis media(OM)and abnormal oVEMP and cVEMP(P>0.05). The serum levels of IL-6 and IL-17 in NPC patients both increased and were significantly associated with abnormal oVEMP and cVEMP after irradiation(P<0.05, all). Conclusion The radiation doses to the inner ears were associated with the incidence of vestibular function damage, but the correlations were mild. OM had no relations with the incidence of vestibular function damage in present study. The inflammatory responses and possible resolution obstacles of inflammation participated in persistent vestibular function damage after irradiation.

Key words: Nasopharyngeal carcinoma, Vestibular function damage, Inflammatory cytokines, Intensity-modulated radiotherapy

CLC Number: 

  • R739.2
[1] Low W K, Toh S T, Wee J, et al. Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study[J]. J Clin Oncol, 2006, 24(12):1904-1909.
[2] 徐英,孙殿水,姜玉华,等.鼻咽癌调强放疗后前庭功能障碍发生情况观察[J].山东医药,2016,56(6):78-79.
[3] Chi F H, Young Y H. Inner ear deficits in irradiated nasopharyngeal carcinoma survivors[J]. Laryngoscope, 2015, 125(11):2565-2571.
[4] Gibb A G, Loh K S. The role of radiation in delayed hearing loss in nasopharyngeal carcinoma[J]. J Laryngol Otol, 2000, 114(2):139-144.
[5] Tseng C C, Wang S J, Young Y H. Comparison of bone-conducted vibration for eliciting ocular vestibular-evoked myogenic potentials: forehead versus mastoid tapping[J]. Otolaryngol Head Neck Surg, 2012, 146(2): 289-294.
[6] Tseng C C, Wang S J, Young Y H. Comparison of head elevation versus rotation methods for eliciting cervical vestibular evoked myogenic potentials via bone-conducted vibration[J]. Int J Audiol, 2013, 52(3):200-206.
[7] Hsin C H, Chen T H, Young Y H, et al. Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients[J]. Otolaryngol Head Neck Surg, 2010, 143(5):662-668.
[8] Young Y H, Lin K L, Ko J Y. Otitis media with effusion in patients with nasopharyngeal carcinoma, post-irradiation[J]. Arch Otolaryngol Head Neck Surg,1995,212(7):765-768.
[9] 殷蔚伯,余子豪,徐国镇,等. 肿瘤放射治疗学[M]. 4版. 北京:中国协和医科大学出版社,2008: 248.
[10] Shabgah A G, Fattahi E, Shahneh F Z. Interleukin-17 in human inflammatory diseases[J]. Postepy Dermatol Alergol, 2014, 31(4):256-261.
[11] Singh R P, Hasan S, Sharma S, et al. Th17 cells in inflammation and autoimmunity[J]. Autoimmun Rev, 2014, 13(12):1174-1181.
[1] ZHANG Caixia, LIU Yangyun, JIANG Wen, LIU Gengxun, CAO Hang, CHEN Qiong, ZHANG Jishuai. Investigation of chemosensitization induced by nitric oxide on nasopharyngeal carcinoma CNE-2 cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 72-78.
[2] ZHOU Yibo, GONG Xiaorong, YU Feng. Effects of miR-150 targeted to Nanog on proliferation and invasion of nasopharyngeal carcinoma side population cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 79-84.
[3] DU Zhihong. Application of oro-nasal combination approach under electronic nasopharyngoscope in the nasopharyngeal biopsy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 117-118.
[4] . Effects of concurrent chemotherapy and radiotherapy on the quality of life in children and adolescents with nasopharyngeal carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 55-58.
[5] . Construction of c-Met target chimeric antigen receptor T cells and evaluation the role on nasopharyngeal carcinoma cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 49-54.
[6] . Efficacy of recombinant human epidermal growth factor in prevention of radioactive oral mucosa inflammation and acute radiation dermatitis for nasopharyngeal carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 95-99.
[7] WANG Yaning, GENG Bo, LI Baiyan, CUI Chaoyang, WANG Qirong. The treatment experience on osteoradionecrosis of skull base with nasopharyngeal carcinoma after radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 42-45.
[8] WANG Junying, LI Xiaofeng. Effect of deproteinized extract of calf blood gel eye on the injury of corneal endothelial cells after nasopharyngeal carcinoma radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 76-79.
[9] ZHAO Yanlian, LU Yongtian, YANG Jihong, ZHANG Juan, MIAO Fangfang, LI Jieping. Relationship between the expression of EGFL7 in nasopharyngeal carcinoma and the invasion and metastasis of tumor [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 31-35.
[10] CHE Juan, ZHAO Hongchun, LI Jinling, WANG Yanfei. The relationship between D-Dimer and nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 47-49.
[11] SHI Da-zhi1, LI Jian-ming2, LUO Zhi-qiang1, LUO Qin1, JING Qian-cheng1. Clinical analysis of nasopharyngeal carcinoma in pregnancy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 28-30.
[12] ZHANG Xiao-peng1, BIAN Feng2, WANG Li-xin2. Expressions and relativity of COX-2 and EGFR in nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 23-27.
[13] ZHANG Zhong-hua1, WANG Xue-hai2, CAI Xiao-lan3. Expression and significance of p-PTEN， p-Akt and p-FoxO1 in nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(2): 55-57.
[14] YANG Jian-ming. Relationship between radioactive otitis media and changes in cross section area of tensor veli palatine (TVP) muscle after radiotherapy in patients with nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 31-33.
[15] XU Yuan-yuan, ZENG Quan, HONG Su-ling, HU Guo-hua. Comparison of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent  chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A meta analysis. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(5): 8-14.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd