JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (4): 103-108.doi: 10.6040/j.issn.1673-3770.0.2016.475

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A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis.

WAN Wenjin, WANG Wen, CHENG Lei   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2016-12-25 Online:2017-08-16 Published:2017-08-16

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Abstract: Objective To evaluate the effectiveness, compliance and safety of subcutaneous immunotherapy(SCIT)and sublingual immunotherapy(SLIT)in the treatment of dust mite-allergic rhinitis. Methods Randomized controlled trials or case-control studies of SCIT and SLIT in treatment of dust mite induced allergic rhinitis were searched in PubMed, EMBASE, Web of Science, the Cochrane Library, WANFANG, VIP, CNKI and CBMdisc databases. The literatures were quality evaluated, filtered and data extracted according to the standard of Oxford CASP, 2004, and the Review Manager 5.2 software was used for meta-analysis. Results 11 literatures including 712 patients were finally selected for analysis, 6 in Chinese and 5 in English. The results showed that there was no significant difference both in the improving nasal symptom scores(SMD=0.05; 95%CI: -0.27-0.38)and in the treatment compliance(RR=1.11, 95%CI: 0.98-1.26)between the SCIT and the SLIT groups. Each was safe and effective treatment although more adverse reactions were observed in SCIT than in SLIT(RR=1.89, 95% CI: 1.00-3.60). Conclusion Both SCIT and SLIT are safe and effective in the treatment of dust mite-allergic rhinitis, while adverse reactions were more frequently observed in SCIT.

Key words: Sublingual immunotherapy, Meta-analysis, Allergic rhinitis, Mites subcutaneous immunotherapy

CLC Number: 

  • R765.21
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