JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (1): 21-26.doi: 10.6040/j.issn.1673-3770.0.2016.507

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Relationship between vitamin D and obstructive sleep apnea hypopnea syndrome in children.

  

  1. Department of Otorhinolaryngology, Key Laboratory of Otolaryngology of Head Ministry, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-12-09 Online:2017-02-16 Published:2017-02-16

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Abstract: Objective To investigate the clinical significance of detecting serum vitamin D level in children with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods During June and Octorber 2016, 69 children with snoring were divided into the OSAHS group(n=47)and primary snoring(PS)group(n=22)according to the apnea-hypopnea index(AHI), and 70 healthy children without snoring served as controls. Venous blood was drawn from each child to measure the serum level of 25(OH)D, triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C). Childrens behaviors were assessed with Conners Parent Symptom Questionnaire(PSQ). Results (1) The mean serum 25(OH)D level of the control, PS and OSAHS groups were 25.38±10.87 ng/mL, 22.00±7.84 ng/mL, and 17.92±6.32 ng/mL(F=9.458, P<0.001). There was significant difference between the OSAHS group and the control group(P<0.001), but no statistical difference between the PS group and the control group(P>0.05). (2) Non-obese children with OSA had significantly lower 25(OH)D level than non-obese children without OSA(P=0.001). There were no significant difference between obese children with OSA and non-obese children with OSA(P=0.566). (3) The 25(OH)D level of the OSAHS group showed positive correlation with anxiety(r=0.337, P=0.020), but no significant correlation with AHI, PSQ, TG, TC, HDL-C and LDL-C(r<0.5, P>0.05). Conclusion The level of serum 25(OH)D is significantly decreased in children with OSAHS, which may help to explore the pathophysiological changes of OSAHS.

Key words: Sleep apnea, obstructive, Vitamin D, Children

CLC Number: 

  • R766.7
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