Abstract: Objective To observe the effect of different drugs in preventing seasonal allergic rhinitis(AR). Methods One hundred and twenty patients with seasonal AR were randomly divided into a Budesonide group, Fexofenadine group, Montelukast group, and control group. The first three groups(groups receiving preventive treatments)were treated with the corresponding drug two weeks before the period of typical symptom onset, while the control group underwent no treatment. The various symptoms, total symptoms, and rhinoconjunctival quality of life were evaluated two weeks before, two weeks after, and four weeks after commencing treatment. Results After two weeks of treatment and four weeks of treatment, the scores for all items in the groups receiving preventive treatment were lower than those of the control group(P<0.05). The nasal symptoms, total symptoms, and rhinoconjunctival quality life of the Budesonide group were lower than those of the other two treatment groups. The ocular symptom score of the Fexofenadine group was lower than those of the other two treatment groups. The nasal congestion symptom score of the Montelukast group was lower than that of the Fexofenadine group. Conclusion Administration of intranasal corticosteroids led to a significant improvement in all nasal symptoms, general symptoms, and quality of life, and may be used as the first choice preventive treatment. Patients with obvious ocular symptoms can be treated with second-generation oral antihistamines, while patients with more significant nasal obstruction may be treated with a combination of leukotriene receptor antagonists for preventive treatment.

Key words: Seasonal, allergicrhinitis, Drug therapy, Preventivetreatment