Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 115-118.doi: 10.6040/j.issn.1673-3770.0.2018.378

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Role of GRP94 and EIF2α in trabecular bone of primary angle-closure glaucoma patients

TENG Xingbo1, CAO Zhi1, SUN Haixia1, LIU Xianjin1, YANGa Weizhou1, ZHU Yan2, ZHU Yuguang2   

  1. Eye Center of Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong, China
  • Published:2019-03-28

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Abstract: Objective The aim of this study was to investigate the role of endoplasmic reticulum stress in trabecular tissue of patients with chronic primary angle-closure glaucoma(PCACG)and to explore its role in the pathogenesis of PCACG. Methods Hematoxylin and eosin(H& E)staining was used to observe changes in the microscopic morphology of trabeculae. Expression of the endoplasmic reticulum stress-related factors, GRP94 and EIF2α, in trabecular tissues, was determined by immunohistochemistry. Results H&E staining showed altered morphology of trabecular tissues, such as the narrow trabeculae and narrow lumen and irregular pigmentation of Schlemm’s canal. Immunohistochemistry results showed that GRP94 and EIF2α were expressed in the trabecular tissue of the control group and their expression increased significantly in the experimental groups(P<0.05). Conclusion These results show that endoplasmic reticulum stress occurs in the trabecular tissue of PCACG patients. The EIF2α signaling pathway may participate in the oxidative damages of trabecular tissue and promote an increase in intraocular pressure.

Key words: GRP94, EIF2a, Endoplasmic reticulum stress, Primary chronic angle-closure glaucoma

CLC Number: 

  • R775.1
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