Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (1): 99-104.doi: 10.6040/j.issn.1673-3770.0.2019.370

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Recent advances regarding extracellular vesicles in head and neck cancers

BIAN Xiaomin1, HAN Guanghong2Review,YU Dan1Guidance   

  1. 1. Department of Otolaryngology and Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130041, Jilin, China;
    2. Department of Geriatric Stomatology, Stomatological Hospital of Jilin University, Changchun 130021, Jilin, China
  • Published:2020-03-06

Abstract: Proliferation and metastasis of tumors are mediated by “mutual dialogue” between cells in the tumor microenvironment(TME). Extracellular vesicles(EVs), vesicle-like bodies secreted by cells, are involved in intercellular communication and are secreted from almost all cell types. They are the key signal mediators between cancer cells and the TME. They play an important role in transporting molecules between cells in the TME. Tumor cell-derived EVs participate in the proliferation and migration of cancer cells through the activation of various signaling pathways in target cells in the TME. The molecular mechanisms and clinical applications of EVs in head and neck cancers are still largely unknown and need further study. In this review, we discuss the TME of head and neck cancers with emphasis on EV-mediated mechanisms in tumor proliferation, invasion, metastasis, angiogenesis, and drug resistance.

Key words: Extracellular vesicles, Exosomes, Head and neck cancers

CLC Number: 

  • R767.04
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