Abstract: Toxic epidermal necrolysis is a serious adverse drug reaction of the epidermis and mucosae that most commonly occurs in adults and is associated with the use of sulfonamides, barbiturates, non-steroid anti-inflammatory drugs, phenytoin, methazolamide, allopurinol, and penicillin. Approximately one out of five patients denied a history of medication, and in approximately one out of three cases, the causes were unknown due to both serious illness and drug treatment. Toxic epidermal necrolysis is one of the few critical diseases in dermatology, with an associated mortality rate of 30%-35%; 20%-40% of the survivors have ocular complications. A few patients can have teary eyes due to tear duct obstruction, but most patients have hyperplasia with eyelashes and blephral epithelium, with squamous biochemical, conjunctival, and corneal new angiogenesis, causing a toxic epidermal necrosis and pyrolysis eye syndrome. Toxic epidermal necrolysis could be managed with timely treatment; however, in some patients, the condition could persist, leading to photophobia, burning pain, vision loss, and even blindness. Here, we report a case of long-term ocular complications of toxic epidermal necrolysis in Tibet.

Key words: Toxic epidermal necrolysis, Stevens-Johnson syndrome, Drug adverse reaction, Critical diseases in dermatology, Ocular complications.