Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (3): 81-86.doi: 10.6040/j.issn.1673-3770.0.2020.016
Previous Articles Next Articles
WANG Zhongwei, YANG Lin, GUO Ya, SUN Bin, WANG Yali, MA Xiulong, REN Hongtao, BAO Xing
|  Kang M, Zhou PT, Long JX, et al. A new staging system for nasopharyngeal carcinoma based on intensity-modulated radiation therapy(IMRT)[J]. Oncotarget, 2017, 8(55):94188-94196. doi:10.18632/oncotarget.21615.
 凌伟, 林初阳, 胡婷, 等. 广东省居民饮用凉茶及煲汤与鼻咽癌发病关系的流行病学研究[J]. 现代肿瘤医学, 2019, 27(7): 1229-1233. doi:10.3969/j.issn.1672-4992.2019.07.033. LING Wei, LIN Chuyang, HU Ting, et al. Association between traditional Chinese herbal soup, tea and risk of nasopharyngeal carcinoma in Guangdong China[J]. J Mod Oncol, 2019, 27(7):1229-1233. doi:10.3969/j.issn.1672-4992.2019.07.033.
 Li YF, Ding JW, Liao LM, et al. Expression of programmed death ligand-1 predicts poor outcome in nasopharyngeal carcinoma[J]. Mol Clin Oncol, 2017, 7(3):378-382. doi:10.3892/mco.2017.1318.
 Liu C, Li G, Yang NT, et al. miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma[J]. Cancer Cell Int, 2017, 17:2. doi:10.1186/s12935-016-0372-8.
 Liu YJ, Tao ZZ, Qu JN, et al. Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma[J]. Biochem Biophys Res Commun, 2017, 491(2):374-381. doi:10.1016/j.bbrc.2017.07.093.
 Chen P, Guo XF, Zhang LM, et al. MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN[J]. Oncotarget, 2017, 8(3):5206-5218. doi:10.18632/oncotarget.14123.
 林少俊, 潘建基, 韩露, 等. 美国癌症研究联合会第七版肿瘤分期对鼻咽癌放疗预后的影响[J]. 中华放射肿瘤学杂志, 2011, 20(6):458-461. doi:10.3760/cma.j.issn.1004-4221.2011.06.004. LIN Shaojun, PAN Jianji, HAN Lu, et al. The different impact of 7th ed AJCC cancer staging system on nasopharyngeal carcinoma treated with conventional radiotherapy and intensity-modulated radiotherapy[J]. Chin J Radiat Oncol, 2011, 20(6):458-461. doi:10.3760/cma.j.issn.1004-4221.2011.06.004.
 中国鼻咽癌临床分期工作委员会. 2010鼻咽癌调强放疗靶区及剂量设计指引专家共识[J]. 中华放射肿瘤学杂志, 2011, 20(4):267-269. doi:10.3760/cma.j.issn.1004-4221.2011.04.001.
 杨青廷, 熊文婧, 刘也, 等. 《2015年第一版NCCN头颈部肿瘤临床实践指南》关于鼻咽癌更新内容及要点解读[J]. 医院与医学, 2016, 4(2):65-68.
 Li HL, Li XL, Ge XL, et al. MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A[J]. Oncotarget, 2016, 7(34):54838-54851. doi:10.18632/oncotarget.10761.
 Fan HN, Shao M, Huang SH, et al. MiR-593 mediates curcumin-induced radiosensitization of nasopharyngeal carcinoma cells via MDR1[J]. Oncol Lett, 2016, 11(6):3729-3734. doi:10.3892/ol.2016.4438.
 Sun KY, Peng T, Chen Z, et al. Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p[J]. Aging(Albany NY), 2017, 9(3):999-1011. doi:10.18632/aging.101205.
 Zou J, Liu L, Wang Q, et al. Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1[J]. Am J Transl Res, 2017, 9(3):1357-1368.
 Han YT, Zhao Q, Zhou J, et al. miR-429 mediates tumor growth and metastasis in colorectal cancer[J]. Am J Cancer Res, 2017, 7(2):218-233.
 Zhu SH, He XC, Wang L. Correlation analysis of miR-200b, miR-200c, and miR-141 with liver metastases in colorectal cancer patients[J]. Eur Rev Med Pharmacol Sci, 2017, 21(10):2357-2363.
 Tian H, He ZK. miR-200c targets nuclear factor IA to suppress HBV replication and gene expression via repressing HBV Enhancer I activity[J]. Biomedecine Pharmacother, 2018, 99:774-780. doi:10.1016/j.biopha.2018.01.141.
 Wu D, Lu P, Mi X, et al. Downregulation of miR-503 contributes to the development of drug resistance in ovarian cancer by targeting PI3K p85[J]. Arch Gynecol Obstet, 2018, 297(3):699-707. doi:10.1007/s00404-018-4649-0.
 王国栋, 黄建涛, 吴洋, 等. miR-429对头颈部鳞状细胞癌增殖的影响[J]. 口腔颌面外科杂志, 2015, 25(3):185-189. doi:10.3969/j.issn.1005-4979.2015.03.005. WANG Guodong, HUANG Jiantao, WU Yang, et al. miR-429 inhibits cell growth of head and neck squamous cell carcinoma[J]. J Oral Maxillofac Surg, 2015, 25(3):185-189. doi:10.3969/j.issn.1005-4979.2015.03.005.
 Pieraccioli M, Imbastari F, Antonov A, et al. Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation[J]. Cell Cycle, 2013, 12(14):2309-2320. doi:10.4161/cc.25405.
 伍思培. MYC通过靶向抑制miR-200c调节鼻咽癌肿瘤细胞的干性及其化疗药物抗性[D]. 广州: 南方医科大学, 2013.
|||CHENG Yao, ZHANG Zhen, YANG Ji, FENG Chengmin, DENG Qicheng, ZHANG Xi, ZHAO Rui, ZHU Xin, WU Junzhi, LIU Hai, DENG Shishan. Expression and clinical significance of CIP2A in hypopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 40-44.|
|||HUA Hongli, LI Song,TAO Zezhang. Research progress of artificial intelligence in the diagnosis and treatment of nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 113-119.|
|||ZHOU Yuxiang,MIAO Beiping, LU Yongtian. Treatment progress of endoscopic surgery for first diagnosed nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 108-112.|
|||LIU Pan, WANG Chuan, ZHAO Zeqi, WU Mei, XU Jifeng, LI Wei, ZHANG Weiqiang, LIU Wen. Five cases of metastatic clear cell carcinoma of the head and neck: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 45-50.|
|||WANG Yingying, ZHOU Han, DONG Weida, XING Guangqian, CHEN Zhibin, ZHANG Qingzhao, ZHANG Liqing. Analysis of distant metastasis and prognosis of adenoid cystic carcinoma of the external auditory canal [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 1-6.|
|||TAN Yufang, YI Tianhua. Clinical characteristics and prognosis of sudden sensorineural hearing loss in post-irradiated nasopharyngeal carcinoma survivors: a report of 18 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 35-39.|
|||FAN Li, LI Yue, XU Ximing. Changes in and prognostic value of the inflammatory index before and after concurrent chemoradiotherapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 36-41.|
|||This study aims to evaluate the level of expression of cyclin E2 in hypopharyngeal cancer and its relationship with clinical characteristics as well as prognosis. MethodsThe protein levels of cyclin E2 in tumor tissues and adjacent normal tissues were assessed by immunohistochemistry staining in 50 cases of hypopharyngeal cancer. The relationship between the expression level of cyclin E2 and clinical data was analyzed using the SPSS software. ResultsProtein levels of cyclin E2 in hypopharyngeal cancer were higher than protein levels of cyclin E2 in normal tissue(Z=-5.764,P=0.000). The cyclin E2 level in tumor tissue correlated with the tumor staging(Z=-1.995, P=0.046)and lymph node metastasis(Z=-2.176, P=0.030). The 5-year survival rates of patients with cyclin E2 positive and negative expression were 40.2% and 81.8%, respectively. Patients with high expression levels of cyclin E2 had a lower survival rate(χ=6.317, P=0.012). ConclusionThe abnormal expression of cyclin E2 protein in tumor tissues indicates that cyclin E2 may be involved in the development of hypopharyngeal cancer and could be a potential diagnostic and prognostic molecular marker.. Expression of cyclin E2 in hypopharyngeal cancer and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 132-137.|
|||The objective of this study was to analyze the effects and possible regulatory mechanisms that Notch receptors could have on cisplatin resistance, observed in nasopharyngeal carcinoma. MethodsWestern blot analysis was used for the detection of Notch receptor expression in nasopharyngeal carcinoma cells and cisplatin-resistant nasopharyngeal carcinoma cells(5-8F, 5-8F/CDDP). Flow cytometry was used to investigate how the combined treatment with 10 μM CDDP and different concentrations of γ-secretase inhibitor(DAPT)could affect apoptosis in 5-8F/CDDP cells. Flow cytometry was also used for the detection of cell cycle stages in DAPT-treated 5-8F / CDDP cells. Finally, western blotting was also used for the detection of drug resistance-related protein expression. All experiments were followed by statistical data analysis. ResultsWe observed significantly higher Notch1 and Notch4 receptor expression in 5-8F/CDDP cells than in 5-8F cells(P=0.003, P=0.004). Furthermore, we described that Notch signaling was inhibited by DAPT in 5-8F/CDDP cells, followed by a significant increase in the apoptosis rate and decrease in cell proliferation, induced by cisplatin in a dose-dependent manner(P<0.05). Moreover, after inhibiting the Notch signaling pathway in 5-8F/CDDP cells, DAPT treatment significantly decreased the expression of Cyclin E and CDK-2, proteins involved in cell cycle regulation, and contributed to blocking the cells in the G1/S phase(P<0.05). At the same time, the expression levels of both the EMT-related protein Slug and the DNA excision repair protein ERCC1 significantly decreased, while that of E-Cadherin was up-regulated. ConclusionUp-regulated expression of Notch1 and Notch4 receptors is associated with cisplatin resistance in nasopharyngeal carcinoma cells. The inactivation of the Notch signaling pathway might thus have the potential to enhance the efficiency of cisplatin chemotherapy in drug-resistant nasopharyngeal carcinoma cells by inhibiting EMT rather than blocking the G1/S cell cycle phase.. Cisplatin resistance in nasopharyngeal carcinoma cells is affected by Notch receptors through the regulation of epithelial-mesenchymal transition rather than cell cycle controlHAN Jibo, ZOU You, YANG Rui, TAO Zezhang Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, ChinaAbstract:Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 105-110.|
|||Rhinogenic headache is caused by rhinosinusitis or abnormal nasal anatomy. Currently, there are clear classifications and pain grading standards to diagnose the same. Further, its mechanism of action is now understood to involve trigeminal nerve stimulation and sensory neuropeptide substance P. Functional endoscopic surgery(FESS)is prioritized as a treatment modality. During surgery, it is imperative to restore the normal anatomy of the nasal cavity. Several clinical studies have reported that FESS was significantly effective in treating rhinogenic headache, with an overall effective rate of 90% and cure rate of 78%. Additionally, one report indicates that postoperative endoscopic examination and dressing change can effectively reduce the occurrence of complications and ensure safety of the treatment.. Dynamic analysis of rhinogenic headacheZHOU Fangming1, XIE Yan2, LIU Yang2 Overview JIANG Luyun2〓Guidance 1. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China 2. Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 130-133.|
|||XU Jinjing, HU Jinghua, WU Yuanqing, DENG Yi, YU Weiwei. Applications of CO2 laser microsurgery on laryngeal precancerous lesions and early glottic laryngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(3): 129-133.|
|||CHEN Huijun, SONG Shenghua, DONG Weida, ZHOU Han. Prognostic role of preoperative fibrinogen levels in patients with laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(2): 110-114.|
|||Yujing DING,Lan LAN,Qiuju WANG,Fei JI,Fen XIONG,Linyi XIE,Haina DING,Yin XIA,Hui ZHAO. Analysis of clinical characteristics and prognosis of post traumatic hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 9-14.|
|||ZONG Xiaofang, HU Guohua, ZHONG Shixun, LEI Yan, JIANG Lizhu, KANG Houyong. Analysis of the factors affecting the prognosis of low-frequency descending sudden hearing loss without vertigo [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 33-37.|
|||CHEN Xuesong, FU Weiwei, LIU Jiangtao. The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 50-53.|