Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 105-112.doi: 10.6040/j.issn.1673-3770.0.2020.393

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Research progress on circRNAs in allergic rhinitis

LIU Zhai1,2,YING Minzheng2   

  1. 1. Graduate School, University of Soccth China, Hengyang 421000, Hunan, China;
    2. Department of Otorhinolaryngology, Yueyang Second People's Hospital, Yueyang 414000, Hunan, China
  • Published:2021-09-29

Abstract: CircRNAs are newly discovered non-coding RNAs found widely in eukaryotes. They lack the 5' cap structure and 3' adenosine tail. It has been confirmed that circRNAs can regulate gene expression in several ways. For example, we found that some circRNAs contain binding sites of the corresponding sequence in microRNAs. These circRNAs act as molecular sponges to bind miRNAs and intercept their suppressive function on mRNAs. The latest research has showed that some circRNAs expressed at high levels can be found in the nasal mucosa in AR, and that they are involved in the regulation of some cytokines related to AR. However, current research has failed to find a correlation between circRNAs and the degree of severity of AR in humans. In summary, this study evaluated the formation mechanisms, characteristics, and biological functions of circRNAs. The study has also described the post-transcriptional control and “molecular sponges” affect in AR, and it has summarized their potential in the diagnosis and treatment of AR. The study findings provide theoretical support for the analysis of AR in the future.

Key words: circRNAs, AR, Posttranscription regulation, Molecular sponge, Diagnosis and treatment

CLC Number: 

  • R765
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