Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 68-71.doi: 10.6040/j.issn.1673-3770.0.2021.059

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Subfoveal choroidal thickness changes following intravitreal ranibizumab treatment in choroidal neovascularization due to pathological myopia

ZHANG Taoran, WANG Wei, LI Mingming, HUANG Yingxiang   

  1. Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Published:2022-04-15

Abstract: Objective To observe the safety and effectiveness of intravitreal injection of ranizumab(IVR)on choroidal neovascularization due to pathological myopia(mCNV), and the changes of subfoveal choroidal thickness. Methods Retrospective case series study. 42 eyes of 38 patients from November 2014 to December 2018 with treatment-naïve active mCNV treatment by IVR were enrolled in the study. All patients were divided into single treatment group and retreatment group according to the injection numbers of IVR. The differences of best corrected visual acuity and subfoveal central choroidal thickness were observed. Results In the repeated treatment group, the injection numbers were 3.77±1.21. The baseline choroidal thickness of the single treatment group was(59.15±10.57)μm, and that of the retreatment group was(49.33±12.76)μm(P=0.023), in which central choroidal thickness(CCT)before retreatment increased to(55.22±7.63)μm(P=0.131). Conclusion 1+PRN regimen of IVR can effectively treat choroidal neovascularization due to pathological myopia. CCT may be a prognostic factor for retreatment.

Key words: pathologic myopia, choroidal neovascularization, subfoveal choroidal thickness, ranibizumab, retreatment

CLC Number: 

  • R774.5
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[1] ObjectiveObjectiveTo analyze the literature on ocular ischemic syndrome published between January , and December , . MethodPapers on OIS that were published between January , and December , , were screened and retrieved from the CNKI and WOS databases, and those that were relevant were searched and analyzed. ResultsIn this analysis, Chinese papers on OIS were cited for times with an h-index of , while foreign papers were cited for times with an h-index of . Of the organizations that published the highest number of papers and had the highest h-indexes, the Capital Medical University and the Polish Medical University of Pomerania were the leading institutions. The Chinese Journal of Ophthalmology was the leading domestic journal, and the Journal of Ophthalmology and Plos One were the leading foreign journals. China published the highest number of papers abroad, China and South Korea had the highest h-indexes. China′s National Natural Science Foundation provided the most support to the field of OIS, accounting for .% of the total domestic literature. The most frequently cited article in the WOS database was by Hayreh, SS, which was on the prevalence and pathogenesis of ocular vascular occlusive disease and melanosis, it was also part of the top ten studies that focused on the utility of OCT in providing insights into OIS and the mechanisms of ischemia and hypoxia. ConclusionThe utility of OCT in providing insights into OIS and the mechanisms of hypoxia and ischemia represents a modern focus of researchers.. Analysis of the literature on ocular ischemic syndrome at home and abroadMENG Bo, HUANG Yingxiang, WANG Kang, ZHAO Lu, WANG Yanling Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 35-40.
[2] To describe characteristics and risk factors associated with central serous chorioretinopathy(CSC)in a hospital-based outpatient sample population. MethodsIn this hospital-based cross-sectional study, CSC patients were recruited from the Beijing Friendship Hospital from 01/2019 to 12/2019. All participants underwent a standardized interview. Logistic regression models were used to assess the risk factors associated with CSC. ResultsA total of 23,878 outpatients were recorded during the period 01/2019-12/2019. Of these, 45 patients(0.19%)were diagnosed with CSC, divided in 37 male patients(82.22%)and 8 female patients(17.78%). The patients′ age ranged from 21 to 65(42.3±10.1)years. Three patients(6.67%)presented a bilateral involvement. Of all the patients, 39 were included in the present analysis. Control patients were matched for age and sex at a ratio of 1:1. The presence of CSC was associated with exposure to steroids(OR=5.04, 95% CI:1.11-22.89), sleep time(going to sleep after 12 pm)(OR=4.16, 95% CI:1.33-13.04)),and shift-work(OR=5.74, 95% CI:1.47-22.45).ConclusionsOur data showed that CSC prevalence in the analyzed outpatients was 0.19%. Exposure to steroids, sleep time, and shift-work were factors related with CSC in the observed population.. Prevalence and risk factors of central serous chorioretinopathy in a hospital-based population YANG Xiufen, YOU Ran, MA Xiumei, WANG Kang, WANG Yanling Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract:Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 75-79.
[3] YANG Xiufen, LI Hongyang, ZHAO Lu,WEI Ying, HU Xiangdong, CHEN Jun, WANG Yanling. Clinical and imaging characteristics in patients with ocular ischemic syndrome [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 119-123.
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[10] LIU Min1, GUO Jian-lian1, ZHANG Hua2. Vitrectomy in treating idiopathic macular epiretinal membrane [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(5): 65-67.
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