鼻腔鼻窦内翻性乳头状瘤与外周血炎症标志物的相关性研究

doi:10.6040/j.issn.1673-3770.0.2021.264

Abstract

Abstract: Objective To investigate the correlation between sinonasal inverted papilloma(SNIP)and peripheral inflammatory blood markers. Methods 62 patients with SNIP who received endoscopic sinus surgery in the Department of Otolaryngology of Henan People's Hospital from February 2019 to March 2021 were selected as the research objects. 62 age-and-sex-mached healthy controls were included in the study. The number of various peripheral blood cells and inflammatory blood markers such as neutrophil-lymphocyte ratio(NLR), platelet-lymphocyte ratio(PLR)of the patient and control groups were compared. According to whether with malignant transformation and recurrence patients, the research groups were further divided into the SNIP group(38 cases), the recurrence group(14 cases)and the cancer group(10 cases). Multiple comparative analysis were performed on the three sets of data. Results There were statistically significant differences between the patients and controls for neutrophil(P<0.001), eosinophil counts(P<0.001), NLR(P=0.016)and PLR(P=0.005). Logistic regression analysis model showed that the increase of NLR(P<0.001), decrease of PLR(P=0.002)and increase of eosinophil counts(P=0.013)were statistically significant. Further multiple comparative analysis showed that the basophil count in the experimental group was statistically different among the three groups. There was statistically significant difference in the basophil count between SNIP and recurrence group(P=0.045), canceration and recurrence group(P=0.017). Conclusion The peripheral blood eosinophil, neutrophil counts, NLR and PLR are correlated with SNIP, and can be used as peripheral blood inflammation markers of SNIP. The increase of NLR、eosinophil counts, and decrease of PLR may be the risk factors of SNIP.

Key words: Sinonasal inverted papilloma, Inflammatory blood markers, Neutrophil-lymphocyte ratio

CLC Number:

R739.62

MA Jingyuan, WU Tianyi, SUN Zhanwei, WANG Weiwei, LI Shichao, WANG Guangke. Correlation between sinonasal inverted papilloma and peripheral inflammatory blood markers[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 35-39.

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Correlation between sinonasal inverted papilloma and peripheral inflammatory blood markers

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