Abstract: Objective The objective of the study is to investigate the clinical efficacy of anti-vascular endothelial growth factor(VEGF)corneal matrix injection combined with operation in the treatment of pseudygium. Methods The case data of one elderly male patient, who developed palpebral adhesion and pterygium after scalding with molten iron in the left eye, were reviewed. The patient underwent left pterygium excision, autologous limbal stem cell conjunctival flap transplantation, oral mucosa transplantation, amniotic membrane covering, and blepharoplasty. Prior to these, the left eye was treated with two amniotic membrane transplantations, an eyelid fissure, and three subconjunctival and intrastromal anti-VEGF injections. Results One month after the operation, the visual acuity of the left eye was 0.2, the blood supply of the transplanted labial mucosa and bulbar conjunctiva was restored, the cornea was locally cloudy, the anterior chamber was deep, the iris had no adhesion, the lens was slightly cloudy, fundus(-). Conclusion This is a rare case of severe palpebral adhesion and pseudopterygium secondary to a heat scald, which is difficult to treat. For hypertrophic pseudopterygium, anti-VEGF corneal matrix injection can be administered first, and operation after pterygium thinning can achieve good clinical efficacy.

Key words: Anti-VEGF, Corneal stromal injection, Scalding with molten iron, Pseudopterygium, Amniotic membrane transplantation, Limbal stem cell transplantation, Labial mucosa transplantation