Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 260-265.doi: 10.6040/j.issn.1673-3770.0.2021.438

Previous Articles     Next Articles

Analysis of sIgE in polysensitized children with allergic rhinitis

LU Weili, JIANG Tao, LI Xianhua   

  1. Department of Otorhinolaryngology, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, Liaoning, China
  • Published:2022-06-15

Abstract: Objective To investigate the distribution of serum specific IgE(sIgE)in polysensitized children with allergic rhinitis(AR)in Dalian. Methods Retrospectively analyzed the sIgE results of 272 polysensitized pediatric AR patients, grouped by sex, age, allergen type and intensity, number and intensity of inhaled and ingested allergens, to compare the distribution of allergens between groups. Results Pearson correlation analysis(r=0.587, P=0.035)showed that polysensitization was positively correlated with age in all AR children, and the intensity was higher. Spearman's correlation analysis(r=-0.913, P<0.001)showed a negative correlation between the number of allergen species and the corresponding number of patients, and the intensity was higher. Based on age, the patients were divided into 3 groups, 2-5 years, 5-9 years, and 10-14 years. There was a negative correlation between the allergen-positive cases and number of allergen species in each group, and the intensity was higher. The top 5 allergen-positive cases were house dust mite/powder mite, Artemisia, cat, egg white and common ragweed. Based on age, there was a significant difference in the frequency of inhalational and ingestion allergens between the 6-9 years old group(t=2.275, P=0.048). There was significant difference in average strength between inhalation and ingestion allergens(t=2.361, P=0.035). There was a significant difference in average strength between inhalatant and ingestant allergens in the 10-14 years old group(t=3.658, P=0.002). The differences in spring, autumn and year-round among inhalatant allergens were not statistically significant in the number, total intensity and mean intensity. Conclusion As children get older and Increased types of contact allergens, the number of children with polysensitization will also increase. Allergen testing needs to be rechecked regularly. Dermatophagoides farinae / Dermatophagoides farinae, Artemisia argyi, cat, egg white and common ragweed are the main allergens of AR children with polysensitization in Dalian, and attention should be paid to prevention and control. The sensitization of ingestant allergens should be paid attention to at the age of 6-9.

Key words: Children, Allergic rhinitis, Allergen, Specific IgE, Polysensitization

CLC Number: 

  • R765.21
[1] Kong WJ, Chen JJ, Zheng ZY, et al. Prevalence of allergic rhinitis in 3-6-year-old children in Wuhan of China[J]. Clinical and experimental allergy, 2009, 39(6): 869-874. doi: 10.1111/j.1365-2222.2009.03206.x.
[2] Li J, Sun B, Huang Y, et al. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64(7): 1083-1092. doi:10.1111/j.1398-9995.2009.01967.x.
[3] Beutner C, Forkel S, Gupta S, et al. Sex- and age-dependent changes in polysensitization to common aeroallergens over 20 years[J]. J Asthma Allergy, 2020, 13: 725-730. doi:10.2147/JAA.S280771.
[4] Schoos AMM, Jelding-Dannemand E, Stokholm J, et al. Single and multiple time-point allergic sensitization during childhood and risk of asthma by age 13[J]. Pediatr Allergy Immunol, 2019, 30(7): 716-723. doi:10.1111/pai.13109.
[5] 程雷, 董震, 孔维佳, 等. 变应性鼻炎诊断和治疗指南(2015年,天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1): 6-24.
[6] Hst A, Andrae S, Charkin S, et al. Allergy testing in children: why, who, when and how? [J]. Allergy, 2003, 58(7): 559-569. doi:10.1034/j.1398-9995.2003.00238.x.
[7] Prigione I, Morandi F, Tosca MA, et al. Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence[J]. Allergy, 2010, 65(6): 740-742. doi:10.1111/j.1398-9995.2009.02285.x.
[8] Roberts G, Peckitt C, Northstone K, et al. Relationship between aeroallergen and food allergen sensitization in childhood[J]. Clin Exp Allergy, 2005, 35(7): 933-940. doi:10.1111/j.1365-2222.2005.02280.x.
[9] Kim KW, Kim EA, Kwon BC, et al. Comparison of allergic indices in monosensitized and polysensitized patients with childhood asthma[J]. J Korean Med Sci, 2006, 21(6): 1012-1016. doi:10.3346/jkms.2006.21.6.1012.
[10] Ciprandi G, Cirillo I. Monosensitization and polysensitization in allergic rhinitis[J]. Eur J Intern Med, 2011, 22(6): e75-e79. doi:10.1016/j.ejim.2011.05.009.
[11] Haanpää L, Af Ursin P, Nermes M, et al. Association of allergic diseases with children's life satisfaction: population-based study in Finland[J]. BMJ Open, 2018, 8(3): e019281. doi:10.1136/bmjopen-2017-019281.
[12] Demoly P, Passalacqua G, Pfaar O, et al. Management of the polyallergic patient with allergy immunotherapy: a practice-based approach[J]. Allergy Asthma Clin Immunol, 2016, 12: 2. doi:10.1186/s13223-015-0109-6.
[13] de Jong AB, Dikkeschei LD, Brand PLP. Sensitization patterns to food and inhalant allergens in childhood: a comparison of non-sensitized, monosensitized, and polysensitized children[J]. Pediatr Allergy Immunol, 2011, 22(2): 166-171. doi:10.1111/j.1399-3038.2010.00993.x.
[14] Kim BK, Kim JY, Kang MK, et al. Allergies are still on the rise? A 6-year nationwide population-based study in Korea[J]. Allergol Int, 2016, 65(2): 186-191. doi:10.1016/j.alit.2015.11.002.
[15] Suh MJ, Park JA, Chang SW, et al. Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization[J]. PLoS One, 2019, 14(1): e0210840. doi:10.1371/journal.pone.0210840.
[16] Fasce L, Tosca MA, Baroffio M, et al. Atopy in wheezing infants always starts with monosensitization[J]. Allergy Asthma Proc, 2007, 28(4): 449-453. doi:10.2500/aap.2007.28.2966.
[17] 姜涛, 李锐, 华娜, 等. 大连地区儿童变应性鼻炎患者血清特异性IgE分析[J]. 中国儿童保健杂志, 2021, 29(8): 918-921. doi:10.11852/zgetbjzz2020-1724. JIANG Tao, LI Rui, HUA Na, et al. Analysis of serum specific IgE in children with allergic rhinitis in Dalian[J]. Chinese Journal of Child Health Care, 2021, 29(8): 918-921. doi:10.11852/zgetbjzz2020-1724.
[18] 李亮, 郎媛媛, 张嘉懿, 等. 天津地区变应性鼻炎患儿吸入性变应原的流行病学特征分析[J]. 中国耳鼻咽喉头颈外科, 2017, 24(3): 140-143. doi:10.16066/j.1672-7002.2017.03.008. LI Liang, LANG Yuanyuan, ZHANG Jiayi, et al. Epidemiological characteristics of inhalational allergen in children with allergic rhinitis in Tianjin[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2017, 24(3): 140-143. doi:10.16066/j.1672-7002.2017.03.008.
[19] 秦雅楠, 王琳, 姜彦, 等. 2008-2017年青岛地区变应性鼻炎常见吸入性变应原分布[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 67-72. doi: 10.6040/j.issn.1673-3770.1.2018.030. QIN Yanan, WANG Lin, JIANG Yan, et al. Characteristics of the distribution of inhaled allergens in patients with allergic rhinitis in Qingdao from 2008 to 2017[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 67-72. doi: 10.6040/j.issn.1673-3770.1.2018.030.
[20] 邓月, 张健, 程寅, 等. 上海地区变应性鼻炎患者变应原特征分析[J]. 第二军医大学学报, 2020, 41(10): 1062-1067. doi:10.16781/j.0258-879x.2020.10.1062. DENG Yue, ZHANG Jian, CHENG Yin, et al. Analysis of allergen characteristics of allergic rhinitis patients in Shanghai, China[J]. Academic Journal of Second Military Medical University, 2020, 41(10): 1062-1067. doi:10.16781/j.0258-879x.2020.10.1062.
[21] 浦洪波, 杜晓东. 无锡地区2 000例变应性鼻炎变应原检测结果分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 105-107. doi: 10.6040/j.issn.1673-3770.0.2018.120. PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(4): 105-107. doi: 10.6040/j.issn.1673-3770.0.2018.120.
[22] 杨晴, 陆美萍, 程雷. 苏皖地区变应性鼻炎患者气传变应原皮肤点刺试验和血清特异性IgE检测的一致性及相关性分析[J]. 山东大学耳鼻喉眼学报, 2021, 35(1): 40-46. doi: 10.6040/j.issn.1673-3770.0.2020.279. YANG Qing, LU Meiping, CHENG Lei. Agreement and association analyses of skin prick testing and serum specific IgE assay for aeroallergen detection in patients with allergic rhinitis from Jiangsu and Anhui areas[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 40-46. 10.6040/j.issn.1673-3770.0.2020.279.
[23] 褚彦玲, 阎艾慧, 邰旭辉, 等. 沈阳地区AR患者血清过敏原分布及主要变应原IgE水平多因素分析[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(7): 502-506. doi:10.13201/j.issn.1001-1781.2018.07.006. CHU Yanling, YAN Aihui, TAI Xuhui, et al. Multiple-factor analysis of serum allergen distribution of patients with allergic rhinitis and level of main allergen IgE in Shenyang area[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(7): 502-506. doi:10.13201/j.issn.1001-1781.2018.07.006.
[1] WANG Xingxin, YANG Xinyu, ZHENG Xiaojun, DING Lin, SHENG Yawen, BI Xiaoyun, YANG Jiguo. Acupoint application therapy for adenoid hypertrophy in children: a case report [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 122-124.
[2] ZHANG Fengzhen, WANG Guixiang, WEI Yunyun, ZHANG Yamei, ZHAO Jing, WANG Hua, LI Hongbin, LI Xiaodan, ZHANG Jie. Perioperative management of children with mild bleeding disorders undergoing adenotonsillectomy procedures [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 66-72.
[3] CHENG Lei, XU Qiuyan, CHEN Hao. Clinical use and significance of allergy testing and diagnostics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 1-6.
[4] NI Jingzi, WAN Wenjin,CHENG Lei. Research progress on health-related quality of life in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 110-115.
[5] LIN Yihang,LI Youjin. Research progress on gut microbiome in children with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 116-122.
[6] LIU Zhen,SONG Xicheng. Mechanisms and research progress of pyroptosis in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 123-129.
[7] LIU Yitong, ZHOU Suizi,QIU Qianhui. Research progress on NLRP3 inflammasome in chronic rhinosinusitis and allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 142-146.
[8] GONG Xiaoyang, CHENG Lei. Analysis of proportion of outpatients with allergic rhinitis during the coronavirus infectious disease 2019 pandemic [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 245-255.
[9] ZHANG Yaqi, LIU Huimin, CAO Linman, WANG Ziyu, LIN Xu, LI Yanping, XUE Gang, WU Jingfang. Expression and significance of the MAPK,PI3K-AKT,NF-κB pathways of allergic rhinitis in mice [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 254-259.
[10] HUANG Kaiyue, LI Xueqing, HAN Gouxin, ZHANG Qinxiu. Meta-analysis of acupoint catgut embedding in the treatment of allergic rhinitis based on the theory of “lung and spleen” [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 266-274.
[11] ZHU Zhengru, ZHANG Xiaobing. Meta-analysis of the curative effect of traditional Chinese medicine decoction combined with conventional western medicine on allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 281-289.
[12] YANG Yang, WANG Xiaoxu, ZHANG Jie. Progress on diagnosis and treatment of middle ear cholesteatoma in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 1-6.
[13] GAO Xinzhong, LING Zongtong, SHEN Ling, LIU Pingfang, LIN Xin, XU Yangyang. Analysis of the efficacy of balloon eustachian tuboplasty combined with adenoidectomy in the treatment of otitis media with effusion in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 7-12.
[14] HU Chunyan, DANG Panhong, ZHANG Rui, FAN Mengyun. Analysis of audiological and imaging characteristics of 149 children with unilateral sensorineural hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 31-36.
[15] DANG Panhong, ZHANG Rui, HU Chunyan, WANG Jie, FAN Mengyun. Clinical analysis of facial nerve decompression via an external transmastoid-subtemporal labyrinth approach in eight children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 37-42.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] HE Shou-huan,CHEN Bin,YIN Shan-kai,SU Kai-ming,JIANG Xiao . Morphological changes of the upper airway in OSAHS patients with UPPP
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(5): 385 -388 .
[2] SONG Xi-cheng,ZHANG Qing-quan,XIA Yong-hong,LIU Lu-yi, YU Lu-xin,WANG Gao,JIANG Xiu-liang . Post-operative ICU monitoring and nursing for patients with OSAHS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(5): 389 -392 .
[3] XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(4): 300 -303 .
[4] ZHANG Qing-quan,LI Xin-min,WANG Qiang,WANG Yong-fu . Some experience of the endoscopy treatment of maxillary sinus lesion with the canine tooth fossa approach[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 38 -39 .
[5] DONG Pin,LI Xiao-yan,TU Li-qiang,MENG Qing-hong,WANG Sang,XIE Jin,JIANG Yan . Reconstruction for advanced hypopharyngeal carcinoma and laryngeal recurrent carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(5): 385 -387 .
[6] JIANG Shao-hong,ZHU Yu-hong,WANG Qiang,SONG Xi-cheng . Intractable primary epistaxis: a report of 101 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(6): 542 -544 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(1): 74 -77 .
[8] LEIXun, LIU Qianghe, KONG Zhongyu, XIANG Qiu, GENG WANping, HUANG Hui, DONG Yiyuan, LIU Fangxian. ARelationship between expression of Survivin and radiosensitization effect of EGCG in xenotransplanted nasopharyngeal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(1): 6 -9 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(2): 73 -74 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(01): 29 -33 .