Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 116-122.doi: 10.6040/j.issn.1673-3770.0.2021.496

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Research progress on gut microbiome in children with allergic rhinitis

LIN YihangOverview,LI Youjin   

  1. Department of Otorhinolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • Published:2022-06-15

Abstract: With increasing awareness of the specialization of the structure and function of microbiota, the relationship between gut microbiota and the occurrence, development, and outcome of allergic diseases has been explored. The development of gut microbiota during childhood is a highly dynamic process and the characteristics of gut microbiota in children of different ages closely correlate with allergic rhinitis(AR). Although AR is the most common chronic respiratory disease in children, it currently has poor clinical outcomes with drug treatment and low acceptability of long-term immunotherapy treatment. Numerous clinical studies have been conducted to explore the benefits of adjusting the gut microbiota in children with AR. This review summarizes the progress in the clinical research of gut microbiota and potential interventions and evaluates the feasibility of fecal microbiota transplantation in treating allergic diseases.

Key words: Gut microbiome, Allergic rhinitis, Fecal microbiota transplantation, Pediatric

CLC Number: 

  • R765.21
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