Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 81-87.doi: 10.6040/j.issn.1673-3770.1.2018.026

Previous Articles     Next Articles

The effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen

LI Lisha1,2, GUAN Kai1,2, WANG Zixi1,2, CUI Le1,2   

  1. Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing 100730, China
  • Online:2019-01-20 Published:2019-01-28

PDF (PC)

422

Abstract: Objective The association between allergic disorder prevalence and monitored air pollutants has been supported by past research evidence. The aim of this study was to evaluate the effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen. Methods Eighty-one patients with allergic rhinitis(AR)caused by cypress pollen were recruited. From 2016 to 2018, patients recorded daily average symptom scores during the cypress pollen season. Meanwhile, the meteorological data were acquired from the Meteorological Data Center of the China Meteorological Administration, and air pollutant data were acquired from the database of the China National Environmental Monitoring Center. The effects of air pollutant concentrations on the daily average symptom scores of patients with AR were then analyzed using the multiple linear regression model. Results A statistical correlation between the concentration of SO2 and daily average AR symptom score was found in this study(regression coefficient=0.038, 95% CI［0.004, 0.072］, P=0.027)after adjusting for the effects of cypress pollen concentration and meteorological variables, while the associations between average symptom score and other air pollutants including PM2.5, PM10, CO, NO2, and O3 were insignificant. Conclusion The severity of AR caused by cypress pollen is correlated with air pollutant concentrations, and SO2 might significantly increase the severity of AR symptoms.

Key words: Allergic rhinitis, Symptom score, Air pollution, Sulfur dioxide, Cypress pollens

CLC Number: 

  • R765
[1] Suárez-Varela MM, Gallardo-Juan A, García-Marcos L, et al. The impact of atmospheric pollutants on the prevalence of atopic eczema in 6-7-year-old schoolchildren in Spain; ISAAC Phase III[J]. Iran J Allergy Asthma Immunol, 2013, 12(3):220-227.
[2] Miyamoto T, Takafuji S. Environment and Allergy[M] // Miyamoto T, Takafuji S. eds. New Trends in Allergy III. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991:459-466. doi:10.1007/978-3-642-46717-2_61
[3] Halonen JI, Lanki T, Yli-Tuomi T, et al. Urban air pollution, and asthma and COPD hospital emergency room visits[J]. Thorax, 2008, 63(7):635-641. doi:10.1136/thx.2007.091371.
[4] Akinbami LJ, Lynch CD, Parker JD, et al. The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001-2004[J]. Environ Res, 2010, 110(3):294-301. doi:10.1016/j.envres.2010.01.001.
[5] Ngoc LTN, Park D, Lee Y, et al. Systematic review and meta-analysis of human skin diseases due to particulate matter[J]. Int J Environ Res Public Health, 2017, 14(12):E1458. doi:10.3390/ijerph14121458.
[6] Canonica GW, Bousquet J, Mullol J, et al. A survey of the burden of allergic rhinitis in Europe[J]. Allergy, 2007, 62(Suppl 85):17-25. doi:10.1111/j.1398-9995.2007.01549.x.
[7] Wang KY, Chau TT. An association between air pollution and daily outpatient visits for respiratory disease in a heavy industry area[J]. PLoS One, 2013, 8(10):e75220. doi:10.1371/journal.pone.0075220.
[8] Lindgren A, Stroh E, Nihlén U, et al. Traffic exposure associated with allergic asthma and allergic rhinitis in adults. A cross-sectional study in southern Sweden[J]. Int J Health Geogr, 2009, 8:25. doi:10.1186/1476-072X-8-25.
[9] Nordling E, Berglind N, Melén E, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies[J]. Epidemiology, 2008, 19(3):401-408. doi:10.1097/EDE.0b013e31816a1ce3.
[10] Ackaert C, Kofler S, Horejs-Hoeck J, et al. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101[J]. PLoS One, 2014, 9(8):e104520. doi:10.1371/journal.pone.0104520.
[11] Zou QY, Shen Y, Ke X, et al. Exposure to air pollution and risk of prevalence of childhood allergic rhinitis: a meta-analysis[J]. Int J Pediatr Otorhinolaryngol, 2018, 112:82-90. doi:10.1016/j.ijporl.2018.06.039.
[12] Zhang FY, Wang WY, Lv J, et al. Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China[J]. Sci Total Environ, 2011, 409(13):2486-2492. doi:10.1016/j.scitotenv.2011.04.007.
[13] Liu MM, Wang D, Zhao Y, et al. Effects of outdoor and indoor air pollution on respiratory health of Chinese children from 50 kindergartens[J]. J Epidemiol, 2013, 23(4):280-287.
[14] Hwang BF, Jaakkola JJ, Lee YL, et al. Relation between air pollution and allergic rhinitis in Taiwanese schoolchildren[J]. Respir Res, 2006, 7:23. doi:10.1186/1465-9921-7-23.
[15] Meng Z. Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide is a systemic oxidative damage agent[J]. Inhal Toxicol,2003,15(2):181-195. doi:10.1080/08958370304476.
[16] Bateson TF, Schwartz J. Children's response to air pollutants[J]. J Toxicol Environ Health Part A, 2008, 71(3):238-243. doi:10.1080/15287390701598234.
[17] Li XJ, Huang LQ, Wang N, et al. Sulfur dioxide exposure enhances Th2 inflammatory responses via activating STAT6 pathway in asthmatic mice[J]. Toxicol Lett, 2018, 285:43-50. doi:10.1016/j.toxlet.2017.12.020.
[18] Cai C, Xu J, Zhang M, et al. Prior SO2 exposure promotes airway inflammation and subepithelial fibrosis following repeated ovalbumin challenge[J]. Clin Exp Allergy, 2008, 38(10):1680-1687. doi:10.1111/j.1365-2222.2008.03053.x.
[19] 王晨霞, 袁芳. 空气污染对变应性鼻炎发病的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(18):1455-1458. doi:10.13201/j.issn.1001-1781.2017.18.019. WANG Chenxia, YUAN Fang. The influence of air pollution on the pathogenesis of allergic rhinitis[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2017, 31(18):1455-1458. doi:10.13201/j.issn.1001-1781.2017.18.019.
[20] Behrendt H, Alessandrini F, Buters J, et al. Environmental pollution and allergy: historical aspects[J]. Chem Immunol Allergy, 2014, 100:268-277. doi:10.1159/000359918.
[21] Lu C, Deng QH, Ou CY, et al. Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China[J]. Chin Sci Bull, 2013, 58(34):4252-4258. doi:10.1007/s11434-013-5725-2.
[22] Tecer LH, Alagha O, Karaca F, et al. Particulate matter(PM(2.5), PM(10-2.5), and PM(10))and children's hospital admissions for asthma and respiratory diseases: a bidirectional case-crossover study[J]. J Toxicol Environ Health Part A, 2008, 71(8):512-520. doi:10.1080/15287390801907459.
[23] 何珊, 牟喆, 彭丽, 等. 气象环境因素对儿童变应性鼻炎自觉症状影响的研究[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(16):1458-1462,1466. doi:10.13201/j.issn.1001-1781.2015.16.012. HE Shan, MOU Zhe, PENG Li, et al. Effects of meteorological and environmental factors on subjective symptoms of allergic rhinitis in children[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2015, 29(16):1458-1462,1466. doi:10.13201/j.issn.1001-1781.2015.16.012.
[24] Gent JF, Belanger K, Triche EW, et al. Association of pediatric asthma severity with exposure to common household dust allergens[J]. Environ Res, 2009, 109(6):768-774. doi:10.1016/j.envres.2009.04.010.
[25] Do DC, Zhao Y, Gao P. Cockroach allergen exposure and risk of asthma[J]. Allergy, 2016, 71(4):463-474. doi:10.1111/all.12827.
[26] 李挚, 何海娟, 孙国强, 等. 北京市区与过敏相关的气传花粉[J]. 基础医学与临床, 2015, 35(6):734-738. doi:10.3390/ijerph14030226. LI Zhi, HE Haijuan, SUN Guoqiang, et al. Allergy-related airborne pollen in urban area of Beijing[J]. Basic Medical Sciences and Clinics, 2015, 35(6):734-738.doi:10.3390/ijerph14030226.
[27] Teng B, Zhang XL, Yi CH, et al. The association between ambient air pollution and allergic rhinitis: further epidemiological evidence from Changchun, northeastern China[J]. Int J Environ Res Public Health, 2017, 14(3):E226. doi:10.3390/ijerph14030226.
[28] Baroody FM, Assanasen P, Chung J, et al. Hot, humid air partially inhibits the nasal response to allergen provocation[J]. Arch Otolaryngol Head Neck Surg, 2000, 126(6):749-754.
[1] QIN Ya′nan, WANG Lin, JIANG Yan, YAN Shu, CHEN Min, YU Longgang, LI Na. Characteristics of the distribution of inhaled allergens in patients with allergic rhinitis in Qingdao from 2008 to 2017 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 67-72.
[2] DU Jingwei, FENG Jun, MA Peng, LI Zhiyong, LI Hongguang. Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 124-127.
[3] HONG Dongdong, LIU Yuanxian, ZOU Lianqiang, WENG Juanling, DENG Wenxian. An analysis of 764 positive skin prick test results for Dermatophagoides farinae in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 119-123.
[4] QI Yan, LIU Junqi, PENG Shuya, LUO Kai, ZHANG Mingxia, WANG Zhenlin. Therapeutic ecacy of endoscopic elective vidian neurectomy for moderate-severe persistent allergic rhinitis with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 109-113.
[5] Yinshi GUO,Hui LU. Research progress of group Ⅱ innate lymphoid cells in the allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 9-12.
[6] CAO Cheng, XU Yu. Clinical compliance and related factors to sublingual immunotherapy in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 114-118.
[7] Qianhui QIU,Junxiao GAO. Synchronous control and long-term efficacy of specific immunotherapy for allergic rhinitis and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 33-37.
[8] JIN Xing, HU Dayu, ZHU Li, DENG Furong, LIU Junxiu. Correlation between PM2.5 and upper airway resistance in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 77-80.
[9] HONG Haiyu, XU Guangfu, YANG Shuowei, SU Rongfei, HUANG Yili, CHI Mengshi,WANG Weihao,YANG Qintai. The prevalence and risk factors of bronchial asthma in patients with allergic rhinitis in Guangdong Province [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 94-98.
[10] LU Hangui, LIN Xinsheng, YAO Danmian, WEI Yongxin, LI Chuangwei. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 66-70.
[11] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[12] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[13] CHEN Ming, YU Xuefei. Opinions on the treatment of chronic rhinosinusitis with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 18-22.
[14] WU Xiangping. Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 68-72.
[15] LI Song, WANG Zonggui, YANG Jingpu, ZHANG Zhuping. Progress of transnasal endoscopic vidian neurectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 72-76.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] YANG Changliang,HUANG Zhiwu,YAO Hangqi,ZHU Yong,SNU Yi . Study on auditory brainstem response[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 9 -13 .
[2] WAN Li-jia,LU Hai-tao,JIANG Yi-dao,LIU Hui,LI Qin,SHE La-zhi . Effect of H-uvulopalatopharyngoplasty on obstructive sleep apnea
hypopnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 204 -205 .
[3] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[5] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[6] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 227 -227 .
[7] LIN Feng,LIANG Yong,LU Yong-tian,WAN Li-xia . Classification and surgical treatment for nasal inverted papilloma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 231 -233 .
[8] BAI Guang-ping,LI Jun,DONG Pin . Endscopic surgery for chronic nasosinusitis and nasal polyps in 180 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 242 -243 .
[9] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[10] LOU Zheng-cai,LOU Fang-yi,JIN Zhong-hai . Etiological analysis of paraesthesia pharynx in 405 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 271 -275 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd