JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 14-17.doi: 10.6040/j.issn.1673-3770.0.2016.105

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Vestibular function damage mechanisms in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy.

LIU Ye1, SUN Dianshui1, YIN Jinjun2, XIA Ming3, XU Ying1, SUN Jianhua1   

  1. 1. Cancer Center, the Second Hospital of Shandong University, Jinan 250033, Shandong, China;2. Cancer Center, Weihai Municipal Hospital, Weihai 264200, Shandong, China;3. Department of Otorhinolaryngology &Head and Neck Surgery, the Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2016-03-13 Online:2016-12-16 Published:2016-12-16

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Abstract: Objective To explore potential mechanisms of vestibular function damage in nasopharyngeal carcinoma(NPC)patients after intensity-modulated radiotherapy(IMRT). Methods Patients who received radical IMRT for their NPC were recruited. The serum levels of IL-6 and IL-17 were detected with ELISA method. Vestibular evoked myogenic potential(VEMP)tests were used to evaluate vestibular function and correlation analyses were used to analyze the potential mechanisms of vestibular function damage. Results Thirty-eight patients were included. The mean and maximum radiation doses to the inner ears were both significantly associated with abnormal ocular VEMP(oVEMP)and cervical VEMP(cVEMP)(P<0.05, all), but the correlations were all mild. There were no significant correlations between otitis media(OM)and abnormal oVEMP and cVEMP(P>0.05). The serum levels of IL-6 and IL-17 in NPC patients both increased and were significantly associated with abnormal oVEMP and cVEMP after irradiation(P<0.05, all). Conclusion The radiation doses to the inner ears were associated with the incidence of vestibular function damage, but the correlations were mild. OM had no relations with the incidence of vestibular function damage in present study. The inflammatory responses and possible resolution obstacles of inflammation participated in persistent vestibular function damage after irradiation.

Key words: Nasopharyngeal carcinoma, Vestibular function damage, Inflammatory cytokines, Intensity-modulated radiotherapy

CLC Number: 

  • R739.2
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