%A %T Efficacy of recombinant human epidermal growth factor in prevention of radioactive oral mucosa inflammation and acute radiation dermatitis for nasopharyngeal carcinoma. %0 Journal Article %D 2017 %J Journal of Otolaryngology and Ophthalmology of Shandong University %R 10.6040/j.issn.1673-3770.0.2016.203 %P 95-99 %V 31 %N 1 %U {http://ebhyxbwk.njournal.sdu.edu.cn/CN/abstract/article_2130.shtml} %8 2017-02-16 %X Objective To observe the efficacy of recombinant human epidermal growth factor(rhEGF)in prevention of radioactive oral mucosa inflammation and acute radiation dermatitis of nasopharyngeal carcinoma(NPC). Methods A total of 50 NPC patients(5 stage Ⅱ, 32 stageⅢ and 13 stage Ⅳa)in the department of radiation oncology of our hospital hospitalized from January 2014 to December 2015 were randomly divided into the experimental group(n=26)and the control group(n=24).The two groups were treated with intensity modulated radiation therapy on the whole course, 6 weeks a radiotherapy cycle. The control group was given cisplatin single agent chemotherapy, and every 7 days for a cycle, 5 to 6 cycles. On the basis of the treatment of the control group, the experimental group was treated with combination of rhEGF(oral spray and neck skin smear gel)in the same period of the treatment. Short-term efficacy of the two groups was evaluated with complete remission, partial remission, stable disease and progression disease. The toxicity and side-effects were evaluated by the National Cancer Institute Common Toxicity Criteria(NCI-CTC). Results The short-term efficacy of the two groups was basically equivalent(P>0.05). No patients died in the two groups due to the toxic side effects, and the main toxicities in the two groups were gastrointestinal toxicity, myelosuppression and abnormal liver function. All patients had happened radioactive oral mucosa inflammation and acute radiation dermatitis of the neck which level was over grade Ⅰ. The incidence of radioactive oral mucosa inflammation and acute radiation dermatitis of the neck over grade Ⅱ level in the experimental group(42.31% and 11.54%)were significantly lower than those of the control group(70.83% and 41.67%)(P=0.042, 0.035). Conclusion The method of combination radiotherapy and chemotherapy with rhEGF in the treatment of NPC can effectively reduce the incidence of 山东大学耳鼻喉眼学报31卷1期 -于斌,等.重组人表皮生长因子预防鼻咽癌放射性口腔黏膜炎和急性放射性皮炎的疗效观察 \=-toxicity and side-effects of radioactive oral mucosa inflammation and acute radiation dermatitis of neck which caused by radiotherapy and chemotherapy.