%A LI Wenjing,LIU Ming %T Research progress on the relationship between the C2H2 zinc finger protein family and laryngeal cancer %0 Journal Article %D 2021 %J Journal of Otolaryngology and Ophthalmology of Shandong University %R 10.6040/j.issn.1673-3770.0.2020.102 %P 125-130 %V 35 %N 1 %U {http://ebhyxbwk.njournal.sdu.edu.cn/CN/abstract/article_2816.shtml} %8 %X Laryngeal cancer is one of the most common malignancies in head and neck cancer. Although continuous progress is being made in the diagnosis and treatment of laryngeal cancer, patient survival rates have not greatly improved. Cysteine-2/histidine-2(C2H2)-type zinc finger proteins(ZNFs), the largest family of transcription factors in humans, are characterized by multiple tandemly arranged zinc fingers. C2H2-type ZNFs are involved in normal biological processes such as transcriptional regulation, organ and tissue development, and differentiation; however, they are also associated with the occurrence and development of cancer. Studies have shown that the abnormal expression of various C2H2-type ZNFs is closely related to the clinicopathologic features and prognosis of cancers. This paper primarily reviews the progress of research on the relationship between C2H2-type ZNFs and laryngeal cancer.