%A WANG Li,LU Yong-hui %T %0 Journal Article %D 2006 %J Journal of Otolaryngology and Ophthalmology of Shandong University %R %P 525-526 %V 20 %N 6 %U {http://ebhyxbwk.njournal.sdu.edu.cn/CN/abstract/article_314.shtml} %8 2006-12-24 %X To investigate the expression of telomerase activity and human telomerase reverse transcriptase(hTERT) in the nasal polyp tissues and their significance. Method: The expression of hTERT of 40 cases of nasal polyp tissues and 10 cases of normal inferior turbinate tissues was detected by immunohistochemical staining (PV9000 twostep kit). Results: The expression of telomerase in normal inferior turbinate tissues and nasal polyp tissues was 0 and 82.5%, respectively, and the difference was significant. The expression of telomerase had no significant correlation to the tumor grade, but had close correlation to the recurrence. Conclusion: The expression of telomerase is closely related with nasal polyp progression. It could be postulated that telomerase activity could be related with the tendency of polyp to recur.