<strong>TLR</strong>通路基因多态性与变应性鼻炎的关联研究

TLR通路基因多态性与变应性鼻炎的关联研究

陈若希,张清照,陆美萍,朱歆洁,程雷

Association of Toll-like receptor pathway gene polymorphisms with allergic rhinitis

Ruoxi CHEN,Qingzhao ZHANG,Meiping LU,Xinjie ZHU,Lei CHENG

表3 TLR2和CD14多态性基因分型及在病例与对照组中的频率分布

Table 3 Genotypes and allele frequencies of TLR2 and CD14 polymorphisms among cases and controls

SNPs	基因型	病例组			对照组		Crude OR(95%CI)	Adjusted OR (95%CI)^a	P ^b
SNPs	基因型	n	%		n	%	Crude OR(95%CI)	Adjusted OR (95%CI)^a	P ^b
TLR2
rs7656411		n = 441			n =493
	GG	112	25.4		156	31.6	1.00 (reference)	1.00 (reference)	0.079
	GT	233	52.8		229	46.5	1.42 (1.05~1.92)	1.41 (1.04~1.91)
	TT	96	21.8		108	21.9	1.23 (0.86~1.79)	1.22 (0.84~1.76)
	GT/TT	329	74.6		337	68.4	1.36 (1.02~1.81)	1.35 (1.01~1.79)	0.035
	T allele	0.451							0.186
rs76112010		n = 446			n = 485
	GG	287	64.4		331	68.3	1.00 (reference)	1.00 (reference)	0.144
	GA	137	30.7		141	29.1	1.12 (0.84~1.49)	1.15 (0.86~1.53)
	AA	22	4.96		13	2.7	1.95 (0.97~3.95)	1.98 (0.98~4.02)
	GA/AA	159	35.7		154	31.2	1.19 (0.91~1.53)	1.22 (0.93~1.60)	0.209
	A allele	0.203							0.089
rs7682814		n = 441			n = 486
	GG	285		64.6	330	67.9	1.00 (reference)	1.00 (reference)	0.074
	GA	134		30.4	145	29.8	1.07 (0.81~1.42)	1.09 (0.82~1.45)
	AA	22		5.00	11	2.26	2.32 (1.10~4.86)	2.29 (1.09~4.81)
	GA/AA	42		15.9	38	13.9	1.15 (0.88~1.52)	1.17 (0.90~1.55)	0.292
	A allele	0.202							0.097
CD14
rs2563298		n = 434			n =479
	CC	336		77.4	326	68.1	1.00 (reference)	1.00 (reference)	0.003
	CA	89		20.5	131	27.3	0.66 (0.48~0.90)	0.65 (0.48~0.89)
	AA	9		2.1	22	4.60	0.40 (0.18~0.88)	0.40 (0.18~0.89)
	CA/AA	98		68.5	153	31.9	0.62 (0.46~0.84)	0.62 (0.46~0.83)	0.002
	A allele	0.123							<0.001
rs2569190		n = 450			n = 481
	AA	174		38.7	166	34.5	1.00 (reference)	1.00 (reference)	0.351
	AG	210		46.7	233	48.4	0.86 (0.65~1.14)	0.86 (0.64~1.15)
	GG	66		14.7	82	17.1	0.78 (0.88~1.92)	0.76 (0.52~1.94)
	AG/GG	276		61.3	315	65.5	0.84 (0.52~1.31)	0.84 (0.64~1.09)	0.188
	G allele	0.380							0.150
rs2569191		n = 441			n = 472
	CC	187		42.4	153	32.4	1.00 (reference)	1.00 (reference)	0.008
	CT	188		42.6	236	50.0	0.65 (0.49~0.87)	0.65 (0.48~0.87)
	TT	66		15.0	83	17.6	0.65 (0.44~0.96)	0.64 (0.44~0.95)
	CT/TT	254		57.6	319	67.6	0.65 (0.50~0.85)	0.65 (0.49~0.85)	0.002
	T allele	0.363							0.006