TLR通路基因多态性与变应性鼻炎的关联研究
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陈若希,张清照,陆美萍,朱歆洁,程雷
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Association of Toll-like receptor pathway gene polymorphisms with allergic rhinitis
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Ruoxi CHEN,Qingzhao ZHANG,Meiping LU,Xinjie ZHU,Lei CHENG
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表4 TLR2和CD14基因分型（MW/MM）与变应性鼻炎易感因素的分层分析
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Table 4 Stratification analyses of TLR2 and CD14 polymorphisms in MW/MM genotype in AR subgroups
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| 变量 | 分组 | rs7656411 病例/对照 | rs2563298 病例/对照 | rs2569191 病例/对照 | | 例数 | Adjusted OR (95%CI)b | 例数 | Adjusted OR (95%CI)b | 例数 | Adjusted OR (95%CI)b | | 年龄(岁) | <18 | 247/239 | 1.33(0.88~1.99) | 244/239 | 0.54(0.36~0.80) | 247/236 | 0.65(0.44~0.94) | | ≥18 | 194/254 | 1.36(0.91~2.06) | 191/240 | 0.73(0.47~1.13) | 194/236 | 0.66(0.44~0.98) | | 性别 | 男 | 295/303 | 1.60(1.12~2.30) | 289/296 | 0.75(0.52~1.07) | 293/289 | 0.66(0.47~0.93) | | 女 | 146/190 | 0.97(0.60~1.57) | 146/183 | 0.42(0.25~0.72) | 148/183 | 0.62(0.40~0.98) | | 哮喘 | 无 | 263/493 | 1.28(0.81~2.03) | 261/479 | 0.45(0.27~0.75) | 262/472 | 0.53(0.35~0.81) | | 有 | 116/493 | 1.61(1.13~2.28) | 115/479 | 0.60(0.42~0.85) | 116/472 | 0.70(0.51~0.96) | | 家族史 | 无 | 120/493 | 1.20(0.76~1.89) | 118/479 | 0.56(0.35~0.92) | 120/472 | 0.85(0.56~1.31) | | 有 | 260/493 | 1.64(1.16~2.33) | 260/479 | 0.55(0.38~0.79) | 260/472 | 0.57(0.42~0.78) | | VAS | <5 | 247/493 | 1.25(0.88~1.77) | 241/479 | 0.65(0.45~0.92) | 246/472 | 0.72(0.52~0.99) | | ≥5 | 194/493 | 1.45(0.99~2.12) | 193/479 | 0.60(0.40~0.88) | 195/472 | 0.57(0.41~0.80) | | IgE a | 低 | 135/493 | 1.41(0.99~2.00) | 234/479 | 0.45(0.31~0.67) | 237/472 | 0.61(0.44~0.84) | | 高 | 206/493 | 1.31(0.90~1.89) | 200/479 | 0.82(0.57~1.19) | 204/472 | 0.71(0.50~0.99) |
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