山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (1): 59-62.doi: 10.6040/j.issn.1673-3770.1.2018.042

• 学术研讨 • 上一篇    下一篇

重视儿童“侧呼吸道”过敏性炎症

杨钦泰*()   

  1. 中山大学附属第三医院耳鼻咽喉头颈外科, 广东 广州 510630
  • 收稿日期:2018-11-19 出版日期:2019-01-20 发布日期:2019-01-28
  • 通讯作者: 杨钦泰 E-mail:yang.qt@163.com
  • 作者简介:杨钦泰,主任医师,医学博士,博士生导师。新加坡国立大学访问学者。主要学术任职:广东省医学会变态反应学分会副主任委员,广东省健康管理学会耳鼻咽喉头颈病学专业委员会副主任委员,广东省行业协会耳鼻咽喉头颈病学专业委员会副主任委员,广东省医学会耳鼻咽喉科学分会常务委员,广东省医师协会耳鼻咽喉科医师分会常务委员,广东省生物医学工程学会耳鼻咽喉科分会常务委员,广东省药学会耳鼻咽喉头颈外科用药专家委员会常务委员,中国医疗保健国际交流促进会过敏科学分会常务委员/副秘书长,中华医学会耳鼻咽喉头颈外科学分会青年委员,中国医师协会耳鼻咽喉科医师分会青年委员。担任《Therapeutics and Clinical Risk Management 》《国际耳鼻咽喉头颈外科》《中国耳鼻咽喉头颈外科》编委,《中华耳鼻咽喉头颈外科杂志》通讯编委。2017年入选“广东省医学杰出青年人才”项目,承担14项国家(主持3项国家自然科学基金面上项目)及省市级科研课题,发表相关研究论文70余篇,获得国家实用新型专利8项,参与编写相关专著3部
  • 基金资助:
    国家自然科学基金(81870704);国家自然科学基金(81670912);广州市产学研重大(对外合作)项目(201704030046)

Paying attention to the 'lateral airway' allergic diseases in children

Qintai YANG*()   

  1. Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China
  • Received:2018-11-19 Online:2019-01-20 Published:2019-01-28
  • Contact: Qintai YANG E-mail:yang.qt@163.com
  • Supported by:
    国家自然科学基金(81870704);国家自然科学基金(81670912);广州市产学研重大(对外合作)项目(201704030046)

摘要:

过敏性疾病是全身多器官的系统性疾病,随年龄增长存在“过敏进程”,具有外在的多种表型,也存在内在的紧密联系,又因年龄和人群的差异而变化多端。由于儿童存在身体结构和免疫系统的动态变化而比较特殊,因此聚焦“儿童”“呼吸道”“过敏性疾病”显得尤为重要。过敏性鼻炎、过敏性哮喘和分泌性中耳炎是三种来自同一气道、不同解剖部位的儿童呼吸道疾病,其关联性越来越受到关注,涉及上、下和侧呼吸道过敏性炎症是否存在一致性值得深入探讨,通过临床研究和循证医学证据提出我们的思考。

关键词: 儿童, 过敏性疾病, 分泌性中耳炎, 侧呼吸道

Abstract:

Allergic diseases are autoimmune diseases that involve multi-organ systems producing a variety of clinical manifestations; concurrently, there is an intrinsic and inseparable link between multiple systems and clinical manifestations, producing a variety of manifestations among different age-groups and populations. Focusing on allergic diseases that are associated with the respiratory airway in children is relatively complicated due to the dynamic changes observed with respect to their body structures and immune systems. Allergic rhinitis, allergic asthma, and otitis media with effusion are three examples of allergic respiratory diseases in children that affect the same airway at different anatomical regions, and the correlation between them is receiving greater attention. Whether the upper, lower, and lateral airways could ever truly be in concurrence with each other is worth an in-depth discussion, and thus, we put forward some minor thoughts and suggestions based on the available clinical research and literature.

Key words: Children, Allergic disease, Otitis media with effusion, Lateral airway

中图分类号: 

  • R765.21

图1

腺样体肥大(AH)、过敏性鼻炎(AR)与分泌性中耳炎(OME)的关系图"

图2

左图为ARIA的“上、下呼吸道一体化”示意图,右图为我们在ARIA的基础上提出来的“上、下、侧呼吸道一体化”模式图"

1 Grossman J . One airway, one disease[J]. Chest, 1997, 111 (2 Suppl): S11- S16.
2 Bousquet J , Van Cauwenberge P , Khaltaev N , et al. Allergic rhinitis and its impact on asthma[J]. J Allergy Clin Immunol, 2001, 108 (5 Suppl): S147- S334.
3 Bousquet J , Khaltaev N , Cruz AA , et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)[J]. Allergy, 2008, 63 (Suppl 86): 8- 160.
doi: 10.1111/j.1398-9995.2007.01620.x
4 韩德民. 过敏性鼻炎[M]. 2版 北京: 人民卫生出版社, 2014.
5 李颖, 赵守琴. 儿童分泌性中耳炎与变应性鼻炎相关研究进展[J]. 中华耳科学杂志, 2016, 14 (2): 295- 298.
doi: 10.3969/j.issn.1672-2922.2016.02.034
LI Ying , ZHAO Shouqin . Advances in clinical research on otitis media with effusion and allergic rhinitis in children[J]. Chinese Journal of Otology, 2016, 14 (2): 295- 298.
doi: 10.3969/j.issn.1672-2922.2016.02.034
6 Zernotti ME , Pawankar R , Ansotegui I , et al. Otitis media with effusion and atopy: is there a causal relationship?[J]. World Allergy Organ J, 2017, 10 (1): 37.
doi: 10.1186/s40413-017-0168-x
7 Tai A , Volkmer R , Burton A . Prevalence of asthma symptoms and atopic disorders in preschool children and the trend over a decade[J]. J Asthma, 2009, 46 (4): 343- 346.
doi: 10.1080/02770900802660998
8 Mandel EM , Casselbrant ML , Rockette HE , et al. Systemic steroid for chronic otitis media with effusion in children[J]. Pediatrics, 2002, 110 (6): 1071- 1080.
doi: 10.1542/peds.110.6.1071
9 Kwon C , Lee HY , Kim MG , et al. Allergic diseases in children with otitis media with effusion[J]. Int J Pediatr Otorhinolaryngol, 2013, 77 (2): 158- 161.
doi: 10.1016/j.ijporl.2012.09.039
10 Tomonaga K , Kurono Y , Mogi G . The role of nasal allergy in otitis media with effusion. A clinical study[J]. Acta Otolaryngol Suppl, 1988, 458: 41- 47.
11 Pau BC , Ng DK . Prevalence of otitis media with effusion in children with allergic rhinitis, a cross sectional study[J]. Int J Pediatr Otorhinolaryngol, 2016, 84: 156- 160.
doi: 10.1016/j.ijporl.2016.03.008
12 Chantzi FM , Kafetzis DA , Bairamis T , et al. IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion[J]. Allergy, 2006, 61 (3): 332- 336.
doi: 10.1111/j.1398-9995.2006.00971.x
13 邓慧仪, 杨钦泰, 王玮豪, 等. 儿童腺样体肥大合并变应性鼻炎对分泌性中耳炎发生率的影响[J]. 中山大学学报(医学科学版), 2017, 38 (1): 101- 105.
doi: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2017.0016
DENG Huiyi , YANG Qintai , WANG Weihao , et al. Incidence of otitis media with effusion in adenoid hypertrophy with allergic rhinitis in children[J]. Journal of Sun Yat-Sen University(Medical Sciences), 2017, 38 (1): 101- 105.
doi: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2017.0016
14 Hurst DS . Efficacy of allergy immunotherapy as a treatment for patients with chronic otitis media with effusion[J]. Int J Pediatr Otorhinolaryngol, 2008, 72 (8): 1215- 1223.
doi: 10.1016/j.ijporl.2008.04.013
15 吴佳欐, 陈淑梅, 田欣, 等. 腺样体肥大儿童伴变应性鼻炎与分泌性中耳炎的相关性分析[J]. 山东大学耳鼻喉眼学报, 2013, 27 (6): 53- 56.
WU Jiali , CHEN Shumei , TIAN Xin , et al. Relationship between allergic rhinitis and secretory otitis media in children with adenoid hypertrophy[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2013, 27 (6): 53- 56.
16 Takeuchi K , Fujita Y , Tomemori T , et al. Analysis of T cell receptor beta chain repertoire in middle ear effusions[J]. Ann Otol Rhinol Laryngol, 1996, 105 (3): 213- 217.
doi: 10.1177/000348949610500307
17 Boisvert P , Wasserman SI , Schiff M , et al. Histamine-induced middle ear effusion and mucosal histopathology in the guinea pig[J]. Ann Otol Rhinol Laryngol, 1985, 94 (2 Pt 1): 212- 216.
doi: 10.1177/000348948509400224
18 Nguyen LH , Manoukian JJ , Tewfik TL , et al. Evidence of allergic inflammation in the middle ear and nasopharynx in atopic children with otitis media with effusion[J]. J Otolaryngol, 2004, 33 (6): 345- 351.
doi: 10.2310/7070.2004.03073
19 Nguyen LH , Manoukian JJ , Sobol SE , et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept[J]. J Allergy Clin Immunol, 2004, 114 (5): 1110- 1115.
doi: 10.1016/j.jaci.2004.07.061
20 Downs BW , Butehorn HFrd , Prazma J , et al. Action of histamine on eustachian tube function[J]. Otolaryngol Head Neck Surg, 2001, 124 (4): 414- 420.
doi: 10.1067/mhn.2001.113943
21 Ebert CS Jr , Rose AS , Blanks DA , et al. Immune modulatory oligonucleotides in prevention of nasal allergen-induced Eustachian tube dysfunction in rats[J]. Otolaryngol Head Neck Surg, 2007, 137 (2): 250- 255.
doi: 10.1016/j.otohns.2007.03.004
22 Cengel S , Akyol MU . The role of topical nasal steroids in the treatment of children with otitis media with effusion and/or adenoid hypertrophy[J]. Int J Pediatr Otorhinolaryngol, 2006, 70 (4): 639- 645.
doi: 10.1016/j.ijporl.2005.08.013
23 崔艳红, 韩富根. 儿童分泌性中耳炎治疗中应用糖皮质激素疗效分析[J]. 中华耳科学杂志, 2013, 11 (3): 448- 450.
doi: 10.3969/j.issn.1672-2922.2013.03.025
CUI Yanhong , HAN Fugen . Nasal steroids for the treatment of secretory otitis media in children[J]. Chinese Journal of Otology, 2013, 11 (3): 448- 450.
doi: 10.3969/j.issn.1672-2922.2013.03.025
24 Rosenfeld RM , Shin JJ , Schwartz SR , et al. Clinical practice guideline: otitis media with effusion (update)[J]. Otolaryngol Head Neck Surg, 2016, 154 (1 Suppl): S1- S41.
doi: 10.1177/0194599815623467
25 Williamson I . Otitis media with effusion[J]. Clin Evid, 2006, (15): 814- 821.
[1] 朱希倩,王佳,孙祖贤,冯建秀,张梦佳,赵颖,王宏,姜敏敏. 上海市杨浦区2022—2024年6~9岁学龄儿童屈光状态分析[J]. 山东大学耳鼻喉眼学报, 2026, 40(3): 102-109.
[2] 宋艳玲,司元元,崔彦. 微量玻璃体切除治疗激光笔致儿童全层黄斑裂孔1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 144-147.
[3] 刘南仙,杨泽垠,韩琳,张爱英,赵宇亮,薛静,孙怡君,邵永良. 视频脑电图在儿童复发性眩晕诊断中的意义[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 20-25.
[4] 黄焕,华红利,邓玉琴,江承洋,王雨薇,杨星海. 儿童过敏性鼻炎、扁桃体腺样体肥大和鼻窦炎之间相关性及其对临床指导价值[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 34-41.
[5] 王华,张丰珍,龙婷,赵靖,李宏彬,王生才,王桂香. 后颅窝肿瘤术后儿童气管切开原因及预后转归分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(4): 168-173.
[6] 乐冰艳,邹剑,雷蕾,文巧,钱应雪. 儿童扁桃体微生物群与免疫调节及疾病关联[J]. 山东大学耳鼻喉眼学报, 2025, 39(4): 193-200.
[7] 黄爱萍,王娟,王丽,耿江桥,王亚芳,温鑫. 儿童原发扁桃体Burkitt淋巴瘤累及上颌骨和肺1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 148-152.
[8] 刘畅,杨景朴,高雨,王文佳. 长春地区儿童变应性鼻炎变应原检测结果分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 51-58.
[9] 付圣尧,陈敏,庞文会,李娜. 内镜辅助个体化手术入路治疗儿童鼻中线囊肿及瘘管[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 65-71.
[10] 陈丹萍,何子键,虞幼军,周晓娓. 儿童突发性聋10年住院病例的疗效及预后相关因素分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 16-22.
[11] 杨娜,柳荫,郭宝,纪尧峰,成晨,张琛,董丽娜. 高频超声在儿童鼻骨骨折闭合复位术的应用研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 41-45.
[12] 王登茂,温鑫,耿江桥,张光远,刘晓峰. 儿童咽鼓管毛息肉合并鼻咽部错构瘤1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 105-109.
[13] 姚婷婷,张德伦,李兰. 婴儿下咽部胃黏膜异位症引发咽喉反流症状1例并文献回顾[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 126-130.
[14] 周莹,王刚,王磊,张晓丽,韩浩伦,李保卫,孙喆喆,吴玮. 咽喉反流相关中耳炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 131-135.
[15] 罗露,周恩,肖旭平,林志强,方志杰,吕晓虹. 等离子点状激发技术在儿童OSA扁桃体腺样体切除术联合围手术期快速康复中的应用[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 26-30.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!