JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (4): 50-55.doi: 10.6040/j.issn.1673-3770.0.2016.292

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Efficacy and safety of subcutaneous immunotherapy with house dust mite extract for allergic rhinitis.

TU Yanyi1,2, SHI Li1,2, ZHAO Li1,2, JIN Peng1,2, ZI Xiaoxue1,2, LI Ang1,2, JIN Yixuan1,2, ZHI Lili   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;2. Department of Otolaryngology, The Second Hospital of Shandong University, Jinan 250033, Shandong, China;3. Department of Otolaryngology, Central Hospital of Zibo, Zibo 255031, Shandong, China
  • Received:2016-06-27 Online:2016-08-16 Published:2016-08-16

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Abstract: Objective Investigate the efficacy and safety of 2-year subcutaneous immunotherapy(SCIT)with HDM extract for allergic rhinitis with/without asthma. Methods A total of 58 patients with HDM-induced AR(35 sensitized to HDM only and 23 sensitized to HDM and other allergens simultaneously)with/without asthma were included. Symptom scores, visual analogue scale and quality of life were assessed before and after 6, 12 and 24 months of SCIT. Local and systemic adverse events were recorded for safety. Results Symptom scores decreased significantly(P<0.05)after 6 months of immunotherapy for both AR and asthma, and continued to decline until the end of the treatment. There was no statistical difference(P>0.05)between monosensitized patients and polysensitized patients in symptom scores after 2-year SCIT. Marked improvements(P<0.05)in quality of life were also observed after 6, 12 and 24 months of SCIT. Most side-effects were local reactions, no serious adverse event was reported during the treatment. Conclusion For AR patients, especially accompanied with asthma, SCIT is an effective and safe treatment.

Key words: Subcutaneous immunotherapy, House dust mite, Efficacy, Asthma, Allergic rhinitis

CLC Number: 

  • R765.21
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