Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 52-55.doi: 10.6040/j.issn.1673-3770.0.2018.408

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Clinical efficacy and safety of different methods of administration of glucocorticoids in the treatment of sudden deafness

ZHANG Junjun1, LIU Haili2, LIU Jiafu2, QIN Xiaofeng2, DU Hongming1, WANG Houhui2   

  1. Department of Respiratory Medicine, Yixian People′s Hospital, Jixian County, Jvxian 276599, Shandong, China
  • Online:2019-07-20 Published:2019-07-22

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Abstract: Objective The aim of the study was to investigate the clinical efficacy and safety of different methods of glucocorticoid administration in the treatment of sudden deafness. Methods One hundred and fifty patients with sudden deafness admitted in our hospital from January 2017 to March 2018 were randomly divided into three groups according to the hospitalization order. Based on the application of improved microcirculation methods, nutritional neuropharmacology, and tympanostomy, the groups were classified as tympanic glucocorticoid injection group, intravenous drip and intravenous infusion of glucocorticoid group, and postauricular mastoid group with postauricular mastoid injection of glucocorticoids. The improvement in hearing and adverse reactions of the three groups were compared after the completion of treatment. Results A comparison of the three groups before and after 2-weeks of hearing improvement treatment suggests that the effect of glucocorticoid injection in the postauricular mastoid region was better than intravenous infusion or tympanic injection of glucocorticoids, and the difference was observed to be statistically significant (P<0.05). However, no significant differences were observed in the rate of adverse reactions and complications among the three groups (P>0.05). Conclusion Glucocorticoid injection in the posterior mastoid area was found to be better for the treatment of sudden deafness. The incidence of adverse reactions is low, and, hence, the treatment can be deemed reliable and safe.

Key words: Sudden deafness, Corticosteroids, Postauricular injection, Tympanic membrane puncture, Clinical efficacy

CLC Number: 

  • R764.437
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