Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (1): 72-77.doi: 10.6040/j.issn.1673-3770.0.2019.464

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Amyloidosis of the head and neck: a clinicopathological study of 23 cases

LIU Yaqin, ZHANG Liqing, ZHANG Jiacheng, DONG Weida, ZHOU Han   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2020-03-06

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Abstract: Objective The objective of this study was to investigate the clinical features,diagnosis, treatment, and prognosisofamyloidosis of the head and neck region. Methods The clinical data of 23 patients who were pathologically diagnosed with amyloidosis and admitted to our hospital from the April of 2007 to October 2018 were collected and analyzed. Results The study included 16 patients with primary localized amyloidosis and 7 patients with secondary localized amyloidosis. All the patients received surgical treatment. Postoperative follow-up ranged from 5 months to 11 years. Recurrence was observed in 2 patients who presented with multiple-localized amyloidosis, hoarseness, and foreign body sensation. Conclusion Clinical manifestations of amyloidosis of the head and neck region are variable. This disease develops slowly and tends to recur. The laryngoscopic characteristics are diverse and necessitate distinction from other tumors.However, it can be diagnosed by staining with Congo red in pathological sections. Treatment of amyloidosis is mostly surgical and based on long-term follow-up.

Key words: Amyloidosis, Head and neck, Laryngoscope, Congo red staining

CLC Number: 

  • R762
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