JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2008, Vol. 22 ›› Issue (6): 491-494.

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Expressions and clinical significance of osteopontin and uPA in squamous cell carcinoma of the larynx

 ZHANG Zhong-Hua1, LIANG Kun1, MA Chao2, LEI Da-Peng1, PAN Xin-Liang1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University, Jinan 250012, China;
    2. Key Laboratory of Otorhinolaryngology, Ministry of Health, Shandong University, Jinan 250012, China
  • Received:2008-10-26 Revised:2008-12-05 Online:2008-12-16 Published:2008-12-16

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Abstract:

To investigate expressions of osteopontin (OPN) and urokinase-type plasminogen activator(uPA) and their relation to the invasiveness and metastasis of squamous cell carcinoma of the human larynx. MethodsExpressions of OPN and uPA in 64 cases of laryngeal carcinoma tissue and 18 cases of adjacent normal tissue were detected by using an immunohistochemistry method. Differences of age, sex, differentiation degree, clinical stage and lymphatic metastasis were analyzed. ResultsIn 64 cases of laryngeal carcinoma tissues, the positive expression rates of OPN and uPA were 62.5%(40/64) and 65.6% (42/64) respectively ,which were obviously higher than those in adjacent normal tissues(P＜0.05).　Expressions of OPN and uPA in carcinoma tissues were related to clinical pathological stage and lymphatic metastasis(P＜0. 05), but not related to age, sex or differentiation degree (P＞0. 05). Expression of OPN was positively correlated with that of uPA in laryngeal carcinoma tissues(r=0.6625, P＜0.05). ConclusionExpressions of OPN and uPA can reflect biological characteristics of laryngeal carcinoma and could be used as important molecular markers in the prognosis of laryngeal carcinoma.

Key words: Laryngeal neoplasms; Osteopontin; Urokinasetype plasminogen activator; Immunohistochemistry; Invasiveness and metastasis

CLC Number: 

  • R739.65
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