JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (4): 30-32.doi: 10.6040/j.issn.1673-3770.0.2014.076

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Experimental study on Scutellarin influence DEX in the process of chemotherapy for nasopharyngeal carcinoma

ZHOU Hui, HUANG Xue-qin, HU Jun-li, YAO Jun, ZHANG Yue-fei, JIANG Feng   

  1. Department of Otolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
  • Received:2014-03-06 Online:2014-08-16 Published:2014-08-16

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Abstract: Objective To investigate the influence of Scutellarin reverse that dexamethasone(DEX)interference on tumor cells-CNE-2Z by Paclitaxel chemotheraping. Methods CNE-2Z cells were treated with Paclitaxel or DEX pretreatment, or in combination with Scutellarin. The cell proliferation was measured by the MTT-assay; Expressions of Caspase-12 and Cyclin D1 were detected by RT-PCR. Results DEX reduced the effect of Paclitaxel -induced proliferation inhibition and apoptosis induction in CNE-2Z cells. But after treated by Scutellarin, the tumor cell sensitivity to Paclitaxel was partially restored. Conclusion DEX could inhibit the effect of the growth inhibition and apoptosis induction by the chemotherapeutic drugs Paclitaxel, but Scutellarin could reverse these effection and restore the sensitivity of CNE-2Z cells to Paclitaxel.

Key words: Dexamethasone, Scutellarin, desensitization, chemotherapy

CLC Number: 

  • R739.62
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