JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (3): 55-.

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IGF-1R and Ki-67 expressions in olfactory epithelium of patients  suffering from dysosmia caused by chronic sinusitis

LIU Qing-hua1, LI Zhi-chun2   

  1. Department of Otolaryngology & Head and Neck Surgery, 1. Affiliated First Hospital of Xiamen University, Xiamen 361003, Fujian, China;
    2. Affiliated First Hospital of Fujian Medical University, Fuzhou 350004, Fujian, China
  • Received:2010-12-12 Revised:2011-01-24 Online:2011-06-16 Published:2011-06-16

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Abstract:

Objective    To study the pathogenesis of dysosphresia in patients with chronic sinusitis, and to discuss expressions and significance of IGF-1R and Ki-67 in olfactory mucosa. Methods     There were 32 cases of chronic sinusitis in the experimental group, and 11 cases in the control group. IGF-1R and Ki-67 expressions were determined by immunohistochemistry.Tissue sections were observed under an optical microscope. Results      Expressions of IGF-1R and Ki-67  in the olfactory epithelium of 32 patients suffering from the dysosmia were lighter than those in the control group(P<0.05). Conclusion     IGF-1R promoting regeneration in the olfactory epithelium was notably decreased in the ofactory epithelium of chronic sinusitis patient and may lead to ofactory dysfunction.

Key words: Insulin-like growth factor 1 R; Ki-67; Sinusitis; Olfactory epithelium;  Dysosmia

CLC Number: 

  • R765.6+3
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