Abstract:

Objective    To test the expression of miR-29b in primary open-angle glaucoma(POAG) patients′ serum and discuss its function in the pathogenesis of POAG. Methods    qRT-PCR was used to detect the expression of miR-29b both in 20 sporadic POAG patients and 20 healthy people. The results were compared. Results        The expression of miR-29b in sporadic POAG patients was 0.15times the value of healthy group. The difference was statistically significant(P=0.03). Conclusion    The expression of miR-29b in sporadic POAG patients′ serum was significantly downregulated， which indicated that miR-29b may play an important role in the pathogenesis of POAG.

Key words: Extracellular matrix, MicroRNA-29b, Primary open-angle glaucoma