JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (2): 48-51.doi: 10.6040/j.issn.1673-3770.0.2017.421

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Effects of nasal continuous positive airway pressure on glucose and lipid metabolism, hs-CRP, and

ZHANG Huifang,YANG Hongzhen   

  1. Department of Otolaryngology, Baoding First Central Hospital, Baoding 071000, Hebei, China
  • Received:2017-10-12 Online:2018-03-20 Published:2018-03-20

Abstract: Objective To investigate the effects of nasal continuous positive airway pressure(NCPAP)on the levels of glucose and lipid metabolism, hs-CRP and S100A12 in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods Forty OSAHS patients were selected for prospective study, and randomly divided into a control group(receiving routine conservative treatment)and an experimental group(receiving NCPAP treatment)by the coin-tossing method, with each group containing 20 patients. The treatment continued for 3 months. Before and after treatment, the levels of blood glucose, blood lipid, hs-CRP and S100A12 were analyzed. Results In both groups, the levels of total cholesterol(TC), triglyceride(TG)and LDL cholesterol were significantly decreased after treatment, while the levels of HDL cholesterol were significantly increased(all P<0.05). (1) The levels of TC, TG and LDL-C in the experimental group were significantly lower than those in the control group, while the levels of HDL-C in the experimental group were significantly higher than those in the control group(P<0.05). (2) Fasting blood glucose(FBG)and 2 h postprandial blood glucose(PBG)levels were significantly decreased after treatment(P<0.05). The levels of FBG and 2 h PBG were significantly lower in the observation group than in the control group(P<0.05). (3) hs-CRP and S100A12 levels were significantly decreased after treatment(P<0.05). The levels of hs-CRP and S100A12 in the experimental group were significantly lower than in the control group(P<0.05). Conclusion Nasal continuous positive airway pressure can significantly regulate blood glucose and lipid metabolism and reduce hs-CRP and S100A12 levels in patients with OSAHS, thereby reducing the cardiovascular complications of OSAHS patients and improving their prognosis.

Key words: Sleep apnea, obstructive, Non-invasive positive pressure ventilation, Glyco-lipid metabolism, C-reactive protein, Calcium binding protein S100A12

CLC Number: 

  • R766.7
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