JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 63-66.doi: 10.6040/j.issn.1673-3770.0.2016.094

Previous Articles     Next Articles

Report of 11 cases of Kimuras disease and review of literature.

JIN Chengxun, ZHAO Xue, LIU Yue, WEI Ning, JIN Chunshun   

  1. Department of Otolaryngology &Head and Neck Surgery, Second Hospital of Jilin University, Changchun 130000, Jilin, China
  • Received:2016-03-08 Online:2016-12-16 Published:2016-12-16

PDF (PC)

875

Abstract: Objective To explorethe clinical signs,symptoms,pathological and laboratory examinations, diagnosis, differential diagnosis and treatmentof Kimuras disease. Methods Clinical data of 11 cases of Kimuras disease were retrospectively reviewed. The characteristics of laboratory and pathological examinations were summarized. The efficacies of surgical treatment and expectant treatmentwere compared. Results All patients were male, aged 39 years on theaverage.The location of the disease was preauricular, retroauricular, neck andsubmaxillay. Theclinical manifestations were painless progressive swelling. Pathologic characteristics were massivelymphadenosis, with the formation of lymphoid folliculars, and eosinophil infiltration. Laboratory examinationsshowed increased peripheral blood eosinophilia, and elevated serum IgE. Conclusion The diagnosis of Kimuras disease is mainly based on clinical manifestations, laboratory and pathological examinations. As the disease is rare, with no specific clinical manifestations, chronic onset, and duration long, misdiagnosis is likely to occur. Kimura disease through or Hormone therapy, radiotherapyand surgery can be adopted to treat this disease.

Key words: Serum IgE, Eosinophils, Kimuras disease

CLC Number: 

  • R780.2
[1] Kim H T, Szeto C. Eosinophilic hyperplastic lymphogranuloma,comparison with Mikuliczos disease[J]. Chin Med J, 1937, 23:699-700.
[2] Kawada A, Takahashi H, Anzai T. Eosinophiliclymphofolliculosis of the skin(Kimura skinulosis[J]. Jpn J Dermatol, 1966, 76:61.
[3] Hosaka N, Minato T, Yoshida S. Kimuras of the skinn of the skeosinophilicepithelioid granulomatous reaction: A finding possibly related to eosinophil apoptosis[J]. Hum Pathol, 2002, 33(5):561-564.
[4] 王恒琨, 巩艳玲, 王仁欣, 等.口腔颌面部Kimura病13例临床病例分析[J].中华血液杂志, 2010, 31(1):55-56. WANG Hengkun, GONG Yanling, WANG Renxin, et al. Case report of 13 oromaxillo-facial region Kimuras disease[J]. Chin J Hematol, 2010, 31(1):55-56.
[5] 王友元, 黄志权, 陈伟良,等.多发性Kimura病1例报道及文献复习[J].中华口腔颌面外科杂志, 2007,5(5):392-395. WANG Youyuan, HUANG Zhiquan, CHEN Weiliang, et al. Multiple Kimuras disease: report of one case and review of the literature[J]. Chin J Oral Maxillofacial Surg, 2007, 5(5):392-395.
[6] Armstrong W B, Allison G, Pena F, et al. Kimuras disease: two case reports and a literature review[J]. Ann Otol Rhinol Laryngol, 1998, 107(12):1066-1071.
[7] Dixit M P, Scott K M, Bracamonte E, et al. Kimura disease with advanced renal damage with anti-tubular basement membrane antibody[J]. Pediatr Nephrol, 2004, 19(12):1404-1407.
[8] Som P M, Biller H F. Kimura disease involving the parotid gland and cervical nodes:CT and MR findings[J]. J comput Assist Tomogr, 1992, 16(2):320-322.
[9] Chusid M J, Rock A L, Sty J R, et al. Kimuras disease: an unusual cause of cervical tumour[J]. Arch Dis Child, 1997, 77(2):153-154.
[10] Rajpoot D K, Pahl M, Clark J. Nephrotic syndrome associated with Kimura disease[J]. Pediatr Nephrol, 2000, 14(6):486-488.
[11] Chun S, Ji H G. Kimuras disease and angiolymphoid hyperplasia with eosinophilia: clinical and histopathologic differences[J]. J Am Acad Dermatol, 1992, 27(6 Pt1):954-958.
[12] Seregard S. Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura disease[J]. Acta Ophthalmol Scand, 2001, 79(1):91-93.
[13] Day T A, Abreo F, Hoajsoe D K, et al. Treatment of Kimuraa should not be confused with Ki[J]. Otolaryngol Head Neck Surg, 1995, 112(2):333-337.
[14] Olsen T G, Helwig E B. Angiolymphoid hyperplasia with eosinophilia. A clinic pathologic study of 116 patients[J]. J Am Acad Dermatol, 1985, 12(5 Pt1):781-796.
[15] Itami J, Arimizu N, Miyoshi T, et al. Radiation therapy in Kimura Kimuramur[J]. Acta Oncol, 1989, 28(4):511-514.
[16] Kim G E, Kim W C, Yang W I, et al. Radiation treatment in patients with recurrent Kimurauramuraimu[J]. Int J Radiat Oncol Biol Phys, 1997, 38(3):607-612.
[17] 林沁, 庄永泽, 陈淑娇.Kimura病1例附文献复习[J].实用医学杂志, 2006, 22(19):2284-2286. LIN Qin, ZHUANG Yongze, CHEN Shujiao. Case report of 1 Kimuras disease and review of the literature[J]. J Prac Med, 2006, 22(19):2284-2286.
[1] ZHANG Ting, WANG Meilan, GAO Yingqin. Research progress of IL-35 in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 139-147.
[2] CAO Zhengyong, LI Xiaobo. Comparison of the safety and efficacy of short-course postoperative topical glucocorticoid adjuvant therapy for eCRSwNP combined with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 43-50.
[3] ZHANG Jie, NIMA Jizong, XU Xiaodong, ZHOU Jing, LIU Jianmin, LUO Yirui, DU Jintao, BA Luo. Effect of Crocin on Type 2 inflammation in eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 61-67.
[4] LIANG Xu,SHI Li. Research progress in biologic targeted drug therapy for chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 30-35.
[5] YI Ruonan,CHEN Fuquan. Eosinophils and Olfactory Dysfunction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 50-55.
[6] LIANG Xu, JIN Peng, ZHAO Li, YU Kena, ZI Xiaoxue, YUAN Guangmei, ZANG Yirang, ZHANG Qinqin, ZHANG Hailing, SHI Li, ZHANG Hongping. Role of nasal nitric oxide in diagnosis of chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 181-188.
[7] WAN Xia, KONG Yonggang, CHEN Shiming, HUA Hongli, WEI Yuanyuan, ZENG Manli. Comparison of sinus computed tomography characteristics in patients with eosinophil and non-eosinophil chronic nasosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 275-280.
[8] LI Chunhua, LIU Xiao,LIU Hongbing. Galectin-10 and chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 106-111.
[9] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[10] ZHANG Liyue, LIU Jinlan, YAO Dongfang, LI Jieen. The expression and significance of interleukin-31, and interleukin-33 and its receptor ST2, in refractory rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 37-41.
[11] ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 54-57.
[12] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[13] QIN Jie-sheng1, WANG Hui-ge1, LIN Xin-qiang1, HONG Liang-li2. Expression and significance of IL-15mRNA in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 34-37.
[14] LIU Jie1， QU Hui1， LU Dao-wen2, GUO Yan-li1. Relationship between autumnal pollinosis and airborne pollens in summerautumn in the Qingdao area [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(5): 51-54.
[15] MENG Qinghua, XIE Jinghua, SU Fang, WANG Lei. Detection of EOS in nasal section of the early stage in patients with allergic rhinitis treated with sublingual specific immunotherapy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(3): 36-39.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd