JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (3): 60-63.doi: 10.6040/j.issn.1673-3770.0.2016.370

Previous Articles     Next Articles

Research progress on the animal model of allergic rhinitis in traditional Chinese medicine.

LI Lizhu1, WU Qing1, YI Xin1, TIAN Li2   

  1. 1. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China;2. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China
  • Received:2016-08-23 Online:2017-06-16 Published:2017-06-16

PDF (PC)

2120

Abstract: Allergic rhinitis(AR)is one of the most common diseases of the otolaryngological department. The research on prevention and treatment of Traditional Chinese Medicine(TCM)function on AR had reached the stage of cytology as well as molecular.The establishment of syndrome differentiated animal model can enhance the connection between TCM basis and clinic. To establish an animal model which can reflect syndrome differentiation of human AR contributes to deeper study of function mechanism of prevention and treatment of TCM on AR.

Key words: Animal model, Syndrome of traditional Chinese medicine, Allergic rhinitis

CLC Number: 

  • R765.21
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 变应性鼻炎诊断和治疗指南(2015年,天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1):6-24. Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2016, 51(1):6-24.
[2] Reed SD, Lee TA, Mc Crory DC. The economic burden of allergic rhinitis: a criticle evaluation of the literature[J]. Pharmacoeccnmics, 2004, 22(3):345-361.
[3] 王世贞,谢立平.卫气虚与变应性鼻炎相关性的初步试验研究[J].中国中西医结合耳鼻咽喉科杂志,1995,3(1):4-7.
[4] Tanaka K, Okamoto Y, Nagaya Y, et al. Anasal allergy model devel-oped in the guinea pig by intranasal application of 2,4-toluene di-Isocyanate[J]. Int Areh Allergy Appl Immunol, 1988, 85(4):392-397.
[5] 陈炯垣,赖月,李冬日,等.混合人血清诱发豚鼠过敏反应死亡模型的改良[J].法医学杂志,2012,28(6):408-412.
[6] 张永靖.变应性鼻炎动物模型造模综述[J].内蒙古医学杂志,2014,46(6):693-696.
[7] 冯纬云.变应性鼻炎动物模型造模综述[J].广西中医学院学报,2009,12(2):77-79.
[8] 李萌,魏肖云,汪受传,等.变应性鼻炎动物模型的研究现状[J].现代中西医结合杂志,2013,22(12):1360-1363.
[9] 陈小野.实用中医证候动物模型学[M].北京:北京医科大学、中国协和医科大学联合出版社,1993:110.
[10] 陈宇,唐月英,周美玲,等.益气固表法治疗肺气虚型变应性鼻炎的研究[J].中华中医药杂志,2015,30(9):3337-3340. CHEN Yu, TANG Yueying, ZHOU Meiling, et al. Effects of tonifying qi and strengthening exterior on treatment of allergic rhinitis rats with lung qi deficiency syndrome[J]. Chin J Trad Chin Med Pharmacy, 2015, 30(9):3337-3340.
[11] 邓婧,彭成,彭顺林,等.鼻敏颗粒对肺气虚型变应性鼻炎大鼠血清IL-4 IL-10水平的影响[J].四川中医,2014,32(8):59-61. DENG Jing, PENG Cheng, PENG Shunlin, et al. Effects of Bimin Granules on serum IL-4 and IL-10 levels of lung-qi-deficiency rats with allergic rhinitis[J]. J Sichuan Trad Chin Med, 2014, 32(8):59-61.
[12] 刘瑶,彭顺林,尹红,等.芪龙颗粒对肺气虚型变应性鼻炎大鼠血清 IL-1 和 IL-4 水平的影响[J].中国实验方剂学杂志,2012,18(14):224-226. LIU Yao, PENG Shunlin, YIN Hong, et al. Influence of Qilong Granula on IL-1 and IL-4 in serum in allergic rhinitis rats with lung-qi-deficiency[J]. Chin J Exp Trad Med Formulae, 2012, 18(14):224-226.
[13] 卢健敏.温肺止流丹对肺气虚变应性鼻炎模型大鼠鼻黏膜组织IL-4mRNA 表达和血清IL-4的影响[J].陕西中医学院学报,2013,36(3):95-96.
[14] 席斌,田道法.变应性鼻炎肺气虚证与血清IL-4和IFN-γ相关性的实验研究[J].中国中西医结合耳鼻咽喉科杂志,2007,15(3):166-170. XI Bin, TIAN Daofa. Experimental study on the association of serum levels of IL-4 and IFN-r with the development of allergic rhinitis in the pattern of Lung Qi deficiency among guinea pigs[J]. Chin Otorhinolaryngol J Integ Med, 2007, 15(3):166-170.
[15] 邱宝珊,刘蓬,黄可儿,等.补中益气汤对脾虚型变应性鼻炎的治疗作用[J].中药新药与临床药理,2003,14(3):147-149. QIU Baoshan, LIU Peng, HUANG Keer, et al. Effect of BuzhongYiqi Decoction for allergic rhinitis with spleen-qi deficiency in guinea pigs[J]. Trad Chin Drug Res Clin Pharmacol, 2003, 14(3):147-149.
[16] 王宇,严道南.脾气虚与变应性鼻炎模型大鼠相关机理的研究[J].南京中医药大学学报,2011,27(2):140-143. WANG Yu, YAN Daonan. Related mechanism between spleen-qi deficiency and allergic rhinitis in rats[J]. J Nanjing TCM Univ, 2011, 27(2):140-143.
[17] 付文祥,谢慧,熊大经,等.脾虚型AR大鼠鼻黏膜白介素mRNA的活性表达[J].中华中医药学刊,2010,28(12):2486-2488. FU Wenxiang, XIE Hui, XIONG Dajing, et al. Activity expression of interleuk in mRNA in nasal mucosa of rats with spleen deficiency type AR[J]. Chin Arch Trad Chin Med, 2010, 28(12):2486-2488.
[18] 李瑛.摄鼽止氯汤对肾阳虚型变应性鼻炎大鼠血清细胞因子IL-5、ECP的影响[D].成都:成都中医药大学,2012.
[19] 阮岩,杨占军,陈蔚,等.温肾补阳法对肾阳虚变应性鼻炎大鼠模型血清Th1/Th2细胞因子表达的影响[J].中药新药与临床药理,2006,17(1):29-31. RUAN Yan, YANG Zhanjun, CHEN Wei, et al. Influence of kidney-yang warming therapy on expression of Th1/Th2 cytokines in rats with allergic rhinitis[J]. Trad Chin Drug Res Clin Pharmacol, 2006, 17(1):29-31.
[20] 贺敏.阳和汤对肾阳虚变应性鼻炎大鼠鼻黏膜ICAM-1,VCAM-1表达的影响[D].成都:成都中医药大学,2008.
[21] 徐慧贤,阮岩,王世贞,等.豚鼠肾阳虚变应性鼻炎模型的建立[J].中药新药与临床药理,2005,16(6):427-429. XU Huixian, RUAN Yan, WANG Shizhen, et al. Establishment of guinea pig models of allergic rhinitis with kidney-yang deficiency[J]. Trad Chin Drug Res Clin Pharmacol, 2005, 16(6):427-429.
[22] 钟筱华,张海丹.肾阳虚变应性鼻炎动物模型的研究[J].中国中医药现代远程教育,2010,8(4):168-170. ZHONG Xiaohua, ZHANG Haidan. Adenine deficiency produced an animal model of allergic rhinitis development[J]. Chin Med Modern Dist Edu Chin, 2010, 8(4):168-170.
[23] 赵秀杰,董霞,杨占泉,等.鼻超敏反应实验模型的建立[J].中华耳鼻咽喉科杂志,1993,28(1):17-18.
[1] LI Kai, LUO Dan. Runmu ling formula ameliorates ocular surface damage in dry eye rats by activating the LC3-ATG5 autophagy pathway and inhibiting inflammatory factor expression [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 92-101.
[2] LYU Qian, TANG Yuan, GU Zijun, SHI Sailei, LIU Ping, WAN Wenjin. Current status of benefit finding among patients with allergic rhinitis and its influence factors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 21-28.
[3] GU Min, LU Meiping. Advances in the application of nanomedicine delivery systems in allergen immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 106-111.
[4] QIN Nana, LI Yufen, SUN Yuhao, WEI Jian, LI Qin. Effect of interleukin-13 receptor-α2 on nasal mucosal remodeling in rats with allergic rhinitis by TGF-β1/Smad signaling pathway [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 71-77.
[5] DU Kangli, ZHENG Zhenyu, XU Zhanjiang, ZHANG Yu, CHEN Lu, LU Mengyao. Construction and validation of risk prediction model for nasal septal deviation complicated with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 78-86.
[6] XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167.
[7] XU Xuemeng, FAN Lei, YU Wangbo, JIANG Zhiyue, PAN Chen, HUANG Yongqin. Meta-analysis of the efficacy of omalizumab in combination with specific immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 26-33.
[8] HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41.
[9] LIU Yijun, GU Yue, GUAN Dayu, YANG Yucheng, SHEN Yang. The long-term clinical efficacy and safety of vidian neurectomy in refractory allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 42-48.
[10] ZHANG Ting, WANG Meilan, GAO Yingqin. Research progress of IL-35 in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 139-147.
[11] ZHANG Zhuping, PENG Zican, XIAO Zhenlong, LI Cheng, YU Di, WANG Xinglong, CHEN Wei, Guo Bei. The value of a novel nasal secretion eosinophil cationic protein-myeloperoxidase test paper assay in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 129-134.
[12] LIU Chang, YANG Jingpu, GAO Yu, WANG Wenjia. Analysis of allergen detection results in children with allergic rhinitis in the Changchun area [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 51-58.
[13] LI Zhicheng, YAN Ya, DAI Liangping, YING Junjie, WANG Renzhong. Research progress of animal models of olfactory disorders [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 158-167.
[14] ZHOU Heqing, SHEN Qi. Research progress on biomarkers of traditional Chinese medicine in the treatment of allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 168-176.
[15] WANG Manxian, ZHENG Quan, YANG Liang. Research progress in the treatment of allergic rhinitis with bacterial lysates [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 141-145.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd