Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (6): 78-80.doi: 10.6040/j.issn.1673-3770.0.2019.199

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Phototriggered imine-cross-linked hydrogels with mitomycin C for prevention of vocal cord adhesion after cordectomy: a canine model

SONG Zhiyuan1, YI Hongliang1, WANG Yang2, YANG Yunlong2、3   

  1. Institute of Extremity Revival, Sixth Peoples Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China;
    3. China Key Laboratory of Institute of Fine Chemical Engineering, University of Science and Technology, Shanghai 200237, China
  • Published:2019-12-23

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Abstract: Objective To evaluate the feasibility of a canine model of vocal cord adhesion(VCA)and to determine the effectiveness of nitro-benzyl alcohol-modified hyaluronic acid(HA-NB)with mitomycin C(MMC)for the prevention of postoperative VCA using a canine model. Methods Sixteen male beagle dogs were divided into four groups(4 dogs in each group)and treated with saline(control group), HA-NB, MMC, or HN-MMC after VCA was induced by radiofrequency coblation using a suspension laryngoscope. At 8 weeks after surgery, the extent of VCA was determined to evaluate the preventive effects of HA-NB, MMC, and HN-MMC. All larynges were harvested and examined histologically. Results VCA induction was successful in all groups. VCA ratio was evaluated at 8 weeks after the initial surgery. The mean VCA ratio in both the HA-NB and MMC groups was not significantly different to that of the control group, but it was lower in the HN-MMC group than that in the control group. The estimated marginal means of HA-NB*MMC were lowest in the HN-MMC group and showed a significant synergistic interaction between HA-NB and MMC. The scar elevation index(SEI)in the HN-MMC group was significantly lower than that in any other groups. Conclusion The combination of HA-NB gel and MMC was more effective for the prevention of postoperative VCA formation than a single application of HA-based gel or MMC.

Key words: Mitomcin C, Hyaluronic acid, Vocal folds adhesion

CLC Number: 

  • R767
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